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Pediatric Migraine Variants: a Review of Epidemiology, Diagnosis, Treatment, and Outcome

Abstract

Pediatric migraine variants, previously known as childhood periodic syndromes, migraine equivalents, or migraine precursors, are a group of periodic or paroxysmal disorders occurring in patients who also have migraine with or without aura, or who have an increased likelihood of developing migraine. They have common key clinical features including periodic or paroxysmal character, normal neurological examination between attacks, family history of migraine, and clinical evolution to classic types of migraine. This article aims to review the pathophysiology, evaluation, and management of the pediatric migraine variants including abdominal migraine, benign paroxysmal vertigo, cyclic vomiting syndrome, and benign paroxysmal torticollis as well as the episodic syndromes that may lead to migraine, infantile colic, alternating hemiplegia of childhood, and vestibular migraine.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.•

    Gelfand AA. Migraine and childhood periodic syndromes in children and adolescents. Curr Opin Neurol. 2013;26:262–8. A review of the different periodic syndromes in children.

    PubMed  Google Scholar 

  2. 2.

    Wyllie WG, Schlesinger B. The periodic group of disorders in childhood. Br J Child DIs. 1933;30:1–21.

    Google Scholar 

  3. 3.••

    Teixeira K, Montenegro MA and Guerreiro M. Migraine equivalents in childhood. J Child Neurol. 2013;00:1–4. A comprehensive review of the different migraine variants in children.

  4. 4.•

    Rosman NP, Douglass LM, Sharif UM, Paolini J. The neurology of benign paroxysmal torticollis of infancy: report of 10 new cases and review of the literature. J Child Neurol. 2009;24:155–60. A good review of literature of patients with BPT.

    PubMed  Google Scholar 

  5. 5.

    Cuenca-Leon E, Corominas R, Fernandez-Castillo N, et al. Genetic analysis of 27 Spanish patients with hemiplegic migraine, basilar-type migraine and childhood periodic syndromes. Cephalalgia. 2008;28:1039–47.

    CAS  PubMed  Google Scholar 

  6. 6.••

    Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33: 653–655, 794-79(6629–808). Provides a comprehensive diagnostic criterion for the different pediatric migraine variants.

  7. 7.•

    Li BUK, Lefevre F, Chelimsky GG, et al. NASPGHAN Consensus statement on the diagnosis and management of CVS. J Pediatr Gastroenterol Nutr. 2008;47(3):379–93. Provides a consensus statement on evaluation and treatment of cyclical vomiting syndrome in children.

    CAS  PubMed  Google Scholar 

  8. 8.

    Lindley KJ, Andrews PL. Pathogenesis and treatment of cyclical vomiting. J Pediatr Gastroenterol Nutr. 2005;41(Suppl1):S38–40.

    PubMed  Google Scholar 

  9. 9.•

    Drumm BR, Bourke B, Drummond L, et al. Cyclical vomiting syndrome in children: a prospective study. Neurogastroenterol Motil. 2012;24:922–7. A prospective study on epidemiology, clinical features, and outcome of children with cyclical vomiting syndrome.

    CAS  PubMed  Google Scholar 

  10. 10.

    Withers GD, Silburn SR, Forbes DA. Precipitants and aetiology of cyclical vomiting syndrome. Acta Pediatr. 1998;87:272–7.

    CAS  Google Scholar 

  11. 11.

    Sato T, Igarashi N, Minami S, et al. Recurrent attacks of vomiting, hypertension and psychotic depression: a syndrome of periodic catecholamine and prostaglandin discharge. Acta Endrocrinol. 1988;117:189–97.

    CAS  Google Scholar 

  12. 12.

    Li BU, Fleisher DR. Cyclic vomiting syndrome: features to be explained by a pathophysiologic model. Dig Dis Sci. 1999;44:13S–8S.

    CAS  PubMed  Google Scholar 

  13. 13.

    Lin YP, Ni YH, Weng WC, Lee WT. Cyclic vomiting syndrome and migraine in children. J Formos Med Assoc. 2011;10(6):383–7.

    Google Scholar 

  14. 14.

    Lee LYW, Abbott L, Mahlanug B, Moodie SJ, Anderson S. The management of cyclic vomiting syndrome: a systematic review. Eur J Gastroenterol Hepatol. 2012;24:1001–6.

    CAS  PubMed  Google Scholar 

  15. 15.

    Symon D, Rusell G. The relationship between cyclic vomiting syndrome and abdominal migraine. J Pediatr Gastroenterol Nutr. 1995;21 Suppl 1:S42–3.

    PubMed  Google Scholar 

  16. 16.•

    Abu-Arafeh I, Russel G. Cyclical vomiting syndrome in children: a population-based study. J Pediatr Gastroenterol Nutr. 1995;21(4):454–8. Provides the epidemiology, clinical features, and outcome of children with cyclical vomiting syndrome.

    CAS  PubMed  Google Scholar 

  17. 17.

    Cullen KH, MacDOnald WB. The periodic syndrome: its nature and prevalence. Med J Aust. 1963;2:167–73.

    Google Scholar 

  18. 18.

    Tache Y. Cyclic vomiting syndrome: the corticotropin-releasing-factor hypothesis. Dig Dis Sci. 1999;44(8 Suppl):79S–86S.

    CAS  PubMed  Google Scholar 

  19. 19.

    Rashed H, Abell TL, Familoni BO, et al. Autonomic function in cyclic vomiting syndrome and classic migraine. Dig Dis Sci. 1999;44(8 Suppl):74S–8S.

    CAS  PubMed  Google Scholar 

  20. 20.

    Boles RG, Chun N, Senadheera D, et al. Cyclic vomiting syndrome and mitochondrial DNA mutations. Lancet. 1997;350:1299–300.

    CAS  PubMed  Google Scholar 

  21. 21.

    Rinaldo P. Mitochondrial fatty acid oxidation disorders and cyclic vomiting syndrome. Dig Dis Sci. 1999;44(8 Suppl):97S–102S.

    CAS  PubMed  Google Scholar 

  22. 22.

    Catto-Smith AG, Ranuh R. Abdominal migraine and cyclical vomiting. Semin Pediatr Surg. 2003;12(4):254–8.

    PubMed  Google Scholar 

  23. 23.

    Kumar N, Bashar Q, Reddy N, et al. Cyclic vomiting syndrome (CVS): is there a difference based on onset of symptoms—pediatric versus adult? BMC Gastroenterol. 2012;12:52.

    PubMed Central  PubMed  Google Scholar 

  24. 24.

    Fitzpatrick E, Bourke B, Drumm B, Rowland M. Outcome for children with cyclical vomiting syndrome. Arch Dis Child. 2007;92:1001–4.

    PubMed Central  CAS  PubMed  Google Scholar 

  25. 25.

    Dignan F, Symon DN, AbuArafeh K, et al. The prognosis of cyclical vomiting syndrome. Arch Dis Child. 2001;84(1):55–7.

    PubMed Central  CAS  PubMed  Google Scholar 

  26. 26.

    Cuvellier JC, Lepine A. Childhood periodic syndromes. Pediatr Neurol. 2010;42:1–11.

    PubMed  Google Scholar 

  27. 27.•

    Pacheva IH, Ivanov IS. Migraine variants: occurrence in pediatric neurology practice. Clin Neurol Neurosurg. 2013;115:1775–83. Provides a review of epidemiology of different migraine variants.

    PubMed  Google Scholar 

  28. 28.

    Fleisher DR, Gornowicz B, Adams K, et al. Cyclic vomiting syndrome in 41 adults: the illness, the patients, and problems of management. BMC Med. 2005;3:20.

    PubMed Central  PubMed  Google Scholar 

  29. 29.

    Benson JM, Zorn SL, Book LS. Sumatriptan in the treatment of cyclic vomiting. Ann Pharmacother. 1995;29:997–9.

    CAS  PubMed  Google Scholar 

  30. 30.

    Hikita T, Hiroko K, Kaneko S, et al. Sumatriptan as a treatment for cyclical vomiting syndrome: a clinical trial. Cephalalgia. 2010;314(4):504–7.

    Google Scholar 

  31. 31.

    Kothare SV. Efficacy of flunarizine in the prophylaxis of cyclical vomiting syndrome and abdominal migraine. Eur J Paediatr Neurol. 2005;9:23–6.

    PubMed  Google Scholar 

  32. 32.

    Liao KY, Chang FY, Wu LT, Wu TC. Cyclic vomiting syndrome in Taiwanese Children. J Formos Med Assoc. 2011;110:14–8.

    PubMed  Google Scholar 

  33. 33.

    Lewis DW, Bigal ME, Winner P. Migraine and the childhood periodic syndromes. In: Winner P, Lewis DW, Rothner AD, editors. Headache in children and adolescence. 2nd ed. Ontario: B.C.Decker; 2008. p. 37–55.

    Google Scholar 

  34. 34.

    Collins BS, Thomas DW. Chronic abdominal pain. Pediatr Rev. 2007;28(9):323–31.

    PubMed  Google Scholar 

  35. 35.

    Thiesen PN. Recurrent abdominal pain. Pediatr Rev. 2002;23:39–46.

    Google Scholar 

  36. 36.

    Mortimer MJ, Kay J, Jaron A. Clinical epidemiology of childhood abdominal migraine in an urban general practice. Dev Med Child Neurol. 1993;35(3):243–8.

    CAS  PubMed  Google Scholar 

  37. 37.

    Abu-Arafeh I, Russell G. Prevalence and clinical features of abdominal migraine compared with those of migraine headache. Arch Dis Child. 1995;72:413–7.

    PubMed Central  CAS  PubMed  Google Scholar 

  38. 38.

    Carson L, Lewis D, Tsou M, et al. Abdominal migraine: an under-diagnosed cause of recurrent abdominal pain in children. Headache. 2011;51:707–12.

    PubMed  Google Scholar 

  39. 39.

    Symon DN, Russell G. Double blind placebo controlled trial of pizotifen syrup in the treatment of abdominal migraine. Arch Dis Child. 1995;72:48–50.

    PubMed Central  CAS  PubMed  Google Scholar 

  40. 40.•

    Russell G, Abu-Arafeh I, Symon D. Abdominal migraine: evidence for existence and treatment options. Pediatr Drugs. 2002;4(1):1–8. A review of pathophysiology and treatment of abdominal migraine.

    Google Scholar 

  41. 41.

    Bentley D, Kehely A, Al-Bayaty M, Michie CA. Abdominal migraine as a cause of vomiting in children: a clinician’s view. J Pediatr Gastroenterol Nutr. 1995;21 Suppl 1:S49–51.

    PubMed  Google Scholar 

  42. 42.

    Tan V, Sahami AR, Peebles R, Shaw RJ. Abdominal migraine and treatment with intravenous valproic acid. Psychomatics. 2006;47:353–5.

    Google Scholar 

  43. 43.

    Weydert JA, Ball TM, Davis MF. Systematic review of treatments for recurrent abdominal pain. Pediatrics. 2003;111:e1–e11.

    PubMed  Google Scholar 

  44. 44.

    Saps M, Li BU. Chronic abdominal pain of functional origin in children. Pediatr Ann. 2006;35(4):246–56.

    PubMed  Google Scholar 

  45. 45.

    Bremner AR, Sandhu BK. Recurrent abdominal pain in childhood: the functional element. Indian Pediatr. 2009;46:375–9.

    CAS  PubMed  Google Scholar 

  46. 46.•

    Scicchitano B, Humphreys G, Mitton SG, Jaiganesh T. Abdominal migraine in childhood: a review. Pediatr Health Med Ther. 2014;5:73–81. A comprehensive review of evaluation and treatment of abdominal migraine.

    Google Scholar 

  47. 47.

    Catala-Beauchamp AI, Gleason RP. Abdominal migraine in children: Is it all in their heads? J Nurs Pract. 2012;8(1):19–26.

    Google Scholar 

  48. 48.

    Huertas-Ceballos A, Logan S, Bennet C, MacArthur C. Pharmacological interventions for recurrent abdominal pain and irritable bowel syndrome in childhood. Cochrane Database Syst Rev. 2008;1:CD003017.

    PubMed  Google Scholar 

  49. 49.

    Kakisaka Y, Wakusawa K, Haginoya K, et al. Efficacy of sumatriptan in two pediatric cases with abdominal pain-related-functional gastrointestinal disorders: does the mechanism overlap that of migraine? J Child Neurol. 2010;25:234–7.

    PubMed  Google Scholar 

  50. 50.

    Worawattanakul M, Rhoads JM, LIchtman SN, et al. Abdominal migraine: prophylactic treatment and follow-up. J Pediatr Gastroenterol Nutr. 1999;28:37–40.

    CAS  PubMed  Google Scholar 

  51. 51.•

    Abu-Arafeh I, Russell G. Paroxysmal vertigo as a migraine equivalent in children: a population-based study. Cephalalgia. 1995;15:22–5. A population-based study on epidemiology, clinical features, and outcome of paroxysmal vertigo in children.

    CAS  PubMed  Google Scholar 

  52. 52.•

    Russell G, Abu-Arafeh I. Paroxysmal vertigo in children-an epidemiological study. Int J Pediatr Otorhinolaryngol. 1999;49(Suppl1):S105–7. Provides epidemiological data of paroxysmal vertigo in children.

    PubMed  Google Scholar 

  53. 53.

    Batuecas-Caletrio A, Martin-Sanchez V, Cordero-Civantos C, et al. Is benign paroxysmal vertigo of childhood a migraine precursor? Eur J Pediatr Neurol. 2013;17:397–400.

    Google Scholar 

  54. 54.

    Marcelli V, Furia T, Marciano E. Vestibular pathways involvement in children with migraine: a neuro-otological study. Headache. 2010;50(1):71–6.

    PubMed  Google Scholar 

  55. 55.••

    Marcelli V, Russo A, Cristiano E, Tessitore A. Benign paroxysmal vertigo of childhood: a 10-year observational follow-up. Cephalalgia.2014;0(0):1-7. A most recent article discussing the long-term outcome of benign paroxysmal vertigo .

  56. 56.

    Lindskog U, Odkvist L, Noaksson L, Wallquist J. Benign paroxysmal vertigo in childhood: a long term follow-up. Headache. 1999;39:33–7.

    CAS  PubMed  Google Scholar 

  57. 57.

    Koehler B. Benign paroxysmal vertigo of childhood: a migraine equivalent. Eur J Pediatr. 1980;134:149–51.

    CAS  PubMed  Google Scholar 

  58. 58.

    Krams B, Echene B, Leydet J, Rivier F and Roubertie A. Benign paroxysmal vertigo of childhood: long-term outcome. Cephalalgia. 31:439–443.

  59. 59.

    Drigo P, Carli G, Laverda AM. Benign paroxysmal vertigo of childhood. Brain Dev. 2001;23:38–41.

  60. 60.

    Mira E, Piacentino G, Lanzi G, Ballottin U. Benign paroxysmal vertigo in childhood. Diagnostic significance of vestibular examination and headache provocation tests. Acta Otolaryngol Suppl. 1984;406:271–4.

    CAS  PubMed  Google Scholar 

  61. 61.

    Lanzi G, Balottin U, Fazzi E, Tagliasacchi M, Manfrin M, Mira E. Benign paroxysmal vertigo of childhood: a long-term follow-up. Cephalalgia. 1994;14:458–60.

    CAS  PubMed  Google Scholar 

  62. 62.

    Hanukoglu A, Somekh E, Fried D. Benign paroxysmal torticollis in infancy. Clin Pediatr. 1984;23:272–4.

    CAS  Google Scholar 

  63. 63.

    Cohen HA, Nussinovitch M, Ashkenasi A, et al. Benign paroxysmal torticollis in infancy. Pediatr Neurol. 1993;9:488–90.

    CAS  PubMed  Google Scholar 

  64. 64.•

    Al-Twaijri WA, Shevell MI. Pediatric migraine equivalents: occurrence and clinical features in practice. Pediatr Neurol. 2002;26:365–8. A review of epidemiology and clinical features of patients with pediatric migraine variants seen in clinical practice.

    PubMed  Google Scholar 

  65. 65.

    Bonnet C, Roubertie A, Doummar D, et al. Developmental and benign movement disorders in childhood. Mov Disord. 2010;25(10):1317–34.

    PubMed  Google Scholar 

  66. 66.

    Giffin NJ, Benton S, Goadsby PJ. Benign paroxysmal torticollis of infancy: four new cases and linkage to CACNA1A mutation. Dev Med Child Neurol. 2002;44:490–3.

    CAS  PubMed  Google Scholar 

  67. 67.

    Vila-Pueyo M, Gene GG, Flotats-Bastardes M, et al. A loss-of-function CACNA1A mutation causing benign paroxysmal torticollis of infancy. Eur J Pediatr Neurol. 2014;18:430–3.

    Google Scholar 

  68. 68.

    Dale RC, Gardiner A, Antony J, Houlden H. Familial PRRT2 mutation with heterogeneous paroxysmal disorders including paroxysmal torticollis and hemiplegic migraine. Dev Med Child Neurol. 2012;54:958–60.

    PubMed  Google Scholar 

  69. 69.

    Dunn DW, Snyder CH. Benign paroxysmal vertigo of childhood. Am J Dis Child. 1976;130:1099–100.

    CAS  PubMed  Google Scholar 

  70. 70.

    Castro-Rodriguez JA, Stern DA, Halonen M, et al. Relation between infantile colic and asthma/atopy: a prospective study in an unselected population. Pediatrics. 2001;108:878–82.

    CAS  PubMed  Google Scholar 

  71. 71.••

    Gelfand AA, Goadsby PJ, Allen IE. The relationship between migraine and infant colic: a systematic review and meta-analysis. Cephalalgia. 2014;0(00):1–10. An extensive systematic review and meta-analysis providing evidence of the relationship of infant colic and migraine.

  72. 72.

    Lucassen PL, Assendelft WJ, van Eijk JT, et al. Systematic review of the occurrence of infantile colic in the community. Arch Dis Child. 2001;84:398–403.

    PubMed Central  CAS  PubMed  Google Scholar 

  73. 73.

    Jan MM, Al-Buhairi AR. Is infantile colic a migraine related phenomenon? Clin Pediatr. 2001;40:295–7.

    CAS  Google Scholar 

  74. 74.•

    Lucassen PL, Assendelft WJJ, Gubbels JW, et al. Effectiveness of treatments for infantile colic: systematic review. Br Med J. 1998;316:1563–9. A good systematic review of treatments for infantile colic.

    CAS  Google Scholar 

  75. 75.

    Algranati PS, Dworkin PH. Infancy problem behaviors. Pediatr Rev. 1992;13:1–8.

    Google Scholar 

  76. 76.

    Bruni O, Fabrizi P, Ottaviano S, et al. Prevalence of sleep disorders in childhood and adolescence with headache: a case–control study. Cephalalgia. 1997;17:492–8.

    CAS  PubMed  Google Scholar 

  77. 77.

    Romanello S, Spiri D, Marcuzzi E, et al. Association between childhood migraine and history of infantile colic. JAMA. 2013;309:1607–12.

    CAS  PubMed  Google Scholar 

  78. 78.

    Epstein LG, Zee PC. Infantile colic and migraine. JAMA. 2013;309:1636–7.

    CAS  PubMed  Google Scholar 

  79. 79.

    Ho TW, Edvinsson L, Goadsby PJ. CGRP and its receptors provide new insights into migraine pathophysiology. Nat Rev Neurol. 2010;6(10):573–82.

    CAS  PubMed  Google Scholar 

  80. 80.

    Engel MA, Becker C, Reeh PW, Neurath MF. Role of sensory neurons in colitis: increasing evidence for a neuroimmune link in the gut. Inflamm Bowel Dis. 2011;17(4):1030–3.

    PubMed  Google Scholar 

  81. 81.

    Verret S, Steele JC. Alternating hemiplegia in childhood: a report of eight patients with complicated migraine beginning in infancy. Pediatrics. 1971;47:675–80.

    CAS  PubMed  Google Scholar 

  82. 82.

    Neville BR, Ninan M. The treatment and management of alternating hemiplegia of childhood. Dev Med Child Neurol. 2007;49:777–80.

    CAS  PubMed  Google Scholar 

  83. 83.

    Bourgeois M, Aicardi J, Goutieres F. Alternating hemiplegia of childhood. J Pediatr. 1993;122:673–9.

    CAS  PubMed  Google Scholar 

  84. 84.••

    Mikati MA, Kramer U, Zupanc ML, et al. Alternating hemiplegia of childhood: clinical manifestations and long-term outcome. Pediatr Neurol. 2000;23:134–41. A comprehensive review of clinical manifestations of long-term outcome of AHC.

    CAS  PubMed  Google Scholar 

  85. 85.•

    Sweney MT, Silver K, Gerard-Blanluet M, et al. Alternating hemiplegia of childhood: early characteristics and evolution of a neurodevelopmental syndrome. Pediatrics. 2009;123:e534–41. A review of the neurodevelopmental outcome of alternating hemiplegia of childhood.

    PubMed  Google Scholar 

  86. 86.

    Tenney JR, Schapiro MB. Child neurology: alternating hemiplegia of childhood. Neurology. 2010;74:e57–9.

    PubMed  Google Scholar 

  87. 87.•

    Panagiotakaki E, Gobbi G, Neville B, et al. Evidence of a non-progressive course of alternating hemiplegia of childhood: study of a large cohort of children and adults. Brain. 2010;133:3598–610. A large cohort study of 157 patients (children and adults) with AHC presenting the natural course of the disorder with evolution of paroxysmal events and neurological symptoms and their long-term outcome.

    PubMed  Google Scholar 

  88. 88.

    Krägeloh I, Aicardi J. Alternating hemiplegia in infants: report of five cases. Dev Med Child Neurol. 1980;22(6):784–91.

    PubMed  Google Scholar 

  89. 89.

    Sakuragawa N, Arima M, Matsumoto S. Nationwide investigation of actual conditions of alternating hemiplegia of children in Japan (in Japanese). Nippon Shonika Gakkai Zasshi (Tokyo). 1988;92:892–8.

    Google Scholar 

  90. 90.

    Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders cranial neuralgias and facial pain. Cephalalgia. 1988;8 Suppl 7:1–96.

    Google Scholar 

  91. 91.•

    Kansagra S, Mikati MA, Vigevano F. Alternating hemiplegia of childhood. Handb Clin Neurol. 2013;112:821–6. A comprehensive review of AHC including diagnosis, pathogenesis, treatment, and outcome.

    PubMed  Google Scholar 

  92. 92.

    Chi L, Xiu-he Z, Liu X, et al. Alternating hemipelgia of childhood in Chinese following long-term treatment with flunarizine and topiramate. Int J Neurosci. 2012;11:506–10.

    Google Scholar 

  93. 93.

    Hosking GP, Cavanagh NP, Wilson J. Alternating hemiplegia: complicated migraine of infancy. Arch Dis Child. 1978;53:656–9.

    PubMed Central  CAS  PubMed  Google Scholar 

  94. 94.

    Gordon N. Alternating hemiplegia of childhood. Dev Med Child Neurol. 1995;37(5):464–8.

    CAS  PubMed  Google Scholar 

  95. 95.

    Saito Y, Inui T, Sakakibara T, et al. Evolution of hemiplegic attacks and epileptic seizures in alternating hemiplegia of childhood. Epilepsy Res. 2010;90:248–58.

    PubMed  Google Scholar 

  96. 96.

    Rinalduzzi S, Valeriani M, Vigevano F. Brainstem dysfunction in alternating hemiplegia of childhood: a neurophysiological study. Cephalalgia. 2006;26:511–9.

    CAS  PubMed  Google Scholar 

  97. 97.

    Kannavakis E, Xaidara A, Papadimitriou A, et al. Alternating hemiplegia of childhood: a syndrome inherited with an autosomal dominant trait. Dev Med Child Neurol. 2003;5:833–6.

    Google Scholar 

  98. 98.

    Swoboda KJ, Kanavakis E, Xaidara A, et al. Alternating hemiplegia of childhood or familial hemiplegic migraine? A novel ATP1A2 mutation. Ann Neurol. 2004;55:884–7.

    CAS  PubMed  Google Scholar 

  99. 99.

    de Vries B, Stam AH, Beker F, et al. CACNA1A mutation linking hemiplegic migraine and alternating hemiplegia of childhood. Cephalalgia. 2008;28:887–91.

    PubMed  Google Scholar 

  100. 100.

    Heinzen EL, Swadoba KJ, Hitomi Y, et al. De novo mutations in ATP1A3 cause alternating hemiplegia of childhood. Nat Genet. 2012;44:1030–4.

    PubMed Central  CAS  PubMed  Google Scholar 

  101. 101.

    Rosewich H, Thiele H, Ohlenbusch A, et al. Heterozygous de novo mutations in ATP1A3 in patients with alternating hemipelgia of childhood: a whole genome sequencing gene identification study. Lancet Neurol. 2012;11:764–73.

    CAS  PubMed  Google Scholar 

  102. 102.

    Boelman C, Lagman-Bartolome AM, MacGregor D, et al. Identical ATP1A3 mutation causes alternating hemiplegia of childhood and rapid-onset dystonia parkinsonism phenotypes. Pediatr Neurol. 2013;51:850–3.

    Google Scholar 

  103. 103.

    Ishii A, Saito Y, Mitsui J, et al. Identification of ATP1A3 mutations by exome sequencing as the cause of alternating hemiplegia of childhood in Japanese patients. PLoS One. 2013;8:e56120.

    PubMed Central  CAS  PubMed  Google Scholar 

  104. 104.

    Hoei-Hansen CE, Dali C, Lyngbye TJB, Duno M, Uldall P. Alternating hemiplegia of childhood in Denmark: clinical manifestations and ATP1A3 mutation status. Eur J Paediatr Neurol. 2014;18:50–4.

    PubMed  Google Scholar 

  105. 105.

    Jiang WJ, Chi ZF, Ma L, et al. Topiramate: a new agent for patients with alternating hemiplegia of childhood. Neuropediatrics. 2006;37:229–33.

    CAS  PubMed  Google Scholar 

  106. 106.

    Neuhauser H, Radtke A, von Brevern M, et al. Migrainous vertigo: prevalence and impact on quality of life. Neurology. 2006;67:1028–33.

    CAS  PubMed  Google Scholar 

  107. 107.••

    Neuhauser H, Leopold M, von Brevern M, Arnold G, Lempert T. The interrelations of migraine, vertigo, and migrainous vertigo. Neurology. 2001;56(4):436–41. This is one of the most significant papers discussing the overlap of migraine and vertigo and the approach to its classification.

    CAS  PubMed  Google Scholar 

  108. 108.

    Gioacchini FM, Alicandri-Ciufelli M, Kaleci S, Magliulo G, Re M. Prevalence and diagnosis of vestibular disorders in children: a review. Int J Pediatr Otorhinolaryngol. 2014;78:718–24.

    PubMed  Google Scholar 

  109. 109.

    Cutrer FM, Baloh RW. Migraine-associated dizziness. Headache. 1992;32(6):300–4.

    CAS  PubMed  Google Scholar 

  110. 110.

    Cass SP, Ankerstjerne JKP, Yetiser S, et al. Migraine-related vestibulopathy. Ann Otol Rhinol Laryngol. 1997;106:182–9.

    CAS  PubMed  Google Scholar 

  111. 111.

    Dieterich M, Brandt T. Episodic vertigo related to migraine (90 cases): vestibular migraine? J Neurol. 1999;246(10):883–92.

    CAS  PubMed  Google Scholar 

  112. 112.•

    Lempert T, Olesen J, Furman J, et al. Vestibular migraine: diagnostic criteria. Consensus document of the Bárány Society and the International Headache Society. J Vest Res. 2012;22:167–72. This paper presents the diagnostic criteria for vestibular migraine, jointly formulated by the Committee for Classification of Vestibular Disorders of the Bárány Society and the Migraine Classification Subcommittee of the International Headache Society (HIS).

    Google Scholar 

  113. 113.•

    Lempert T. Vestibular migraine. Semin Neurol. 2013;33:212–8. An up-to-date review article on epidemiology, pathogenesis, diagnosis, and treatment of vestibular migraine.

    PubMed  Google Scholar 

  114. 114.•

    Shin JH, Kim YK, Kim HJ, Kim JS. Altered brain metabolism in vestibular migraine: comparison of interictal and ictal findings. Cephalalgia. 2014;34(1):58–67. First report of functional imaging of the brain during an attack of vestibular migraine.

  115. 115.

    Lee H, Jen JC, Wang H, et al. A genome-wide linkage scan of familial benign recurrent vertigo: linkage to 22q12 with evidence of heterogeneity. Hum Mol Genet. 2006;15(2):251–8.

    CAS  PubMed  Google Scholar 

  116. 116.

    Oh AK, Lee H, Jen JC, Corona S, Jacobson KM, Baloh RW. Familial benign recurrent vertigo. Am J Med Genet. 2001;100(4):287–91.

    CAS  PubMed  Google Scholar 

  117. 117.

    Bahmad Jr F, DePalma SR, Merchant SN, et al. Locus for familial migrainous vertigo disease maps to chromosome 5q35. Ann Otol Rhinol Laryngol. 2009;118(9):670–6.

    PubMed Central  PubMed  Google Scholar 

  118. 118.

    Whitney SL, Wrisley DM, Brown KE, Furman JM. Physical therapy for migraine-related vestibulopathy and vestibular dysfunction with history of migraine. Laryngoscope. 2000;110(9):1528–34.

    CAS  PubMed  Google Scholar 

  119. 119.

    Reploeg MD, Goebel JA. Migraine-associated dizziness: patient characteristics and management options. Otol Neurotol. 2002;23(3):364–71.

    PubMed  Google Scholar 

  120. 120.

    Neuhauser H, Radtke A, von Brevern M, Lempert T. Zolmitriptan for treatment of migrainous vertigo: a pilot randomized placebo-controlled trial. Neurology. 2003;60(5):882–3.

    CAS  PubMed  Google Scholar 

  121. 121.

    Bisdorff AR. Treatment of migraine related vertigo with lamotrigine an observational study. Bull Soc Sci Med Grand Duche Luxemb. 2004;2:103–8.

    PubMed  Google Scholar 

  122. 122.

    Carmona S, Settecase N. Use of topiramate (Topamax) in a subgroup of migraine-vertigo patients with auditory symptoms. Ann N Y Acad Sci. 2005;1039:517–20.

    CAS  PubMed  Google Scholar 

  123. 123.

    Iwasaki S, Ushio M, Chihara Y, Ito K, Sugasawa K, Murofushi T. Migraine-associated vertigo: clinical characteristics of Japanese patients and effect of lomerizine, a calcium channel antagonist. Acta Otolaryngol Suppl. 2007;559:45–9.

    PubMed  Google Scholar 

  124. 124.

    Fotuhi M, Glaun B, Quan SY, Sofare T. Vestibular migraine: a critical review of treatment trials. J Neurol. 2009;256(5):711–6.

    PubMed  Google Scholar 

  125. 125.

    Lepcha A, Amalanathan S, Augustine AM, Tyagi AK, Balraj A. Flunarizine in the prophylaxis of migrainous vertigo: a randomized controlled trial. Eur Arch Otorhinolayngol. 2014;271(11):2931–6.

    Google Scholar 

  126. 126.

    Radtke A, von Brevern M, Neuhauser H, Hottenrott T, Lempert T. Vestibular migraine: long-term follow-up of clinical symptoms and vestibulo-cochlear findings. Neurology. 2012;79(15):1607–14.

    PubMed  Google Scholar 

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Ana Marissa Lagman-Bartolome and Christine Lay declare that they have no conflict of interest.

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Correspondence to Ana Marissa Lagman-Bartolome.

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Lagman-Bartolome, A.M., Lay, C. Pediatric Migraine Variants: a Review of Epidemiology, Diagnosis, Treatment, and Outcome. Curr Neurol Neurosci Rep 15, 34 (2015). https://doi.org/10.1007/s11910-015-0551-3

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Keywords

  • Childhood periodic syndromes
  • Cyclic vomiting syndrome
  • Abdominal migraine
  • Benign paroxysmal torticollis
  • Benign paroxysmal vertigo
  • Infantile colic
  • Alternating hemiplegia of childhood
  • Vestibular migraine
  • Motion sickness