Neurologic Manifestations of Gastrointestinal and Liver Diseases

  • José M. FerroEmail author
  • Sofia Oliveira
Neurology of Systemic Disease (J Biller, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Neurology of Systemic Disease


Hepatic and gastrointestinal disorders can produce a wide spectrum of neurologic complications both affecting the central nervous system (CNS) and the peripheral nervous system. These manifestations range in severity from coma in acute liver failure and acute pancreatitis, to minor cognitive changes in chronic portosystemic encephalopathy and hepatitis C. Cerebrovascular diseases can complicate hepatitis C infection and inflammatory bowel disease. Demyelinating disorders may co-exist with inflammatory bowel disease. Anti-tumor necrosis factor alpha drugs may induce demyelination. Ataxia may occur in malabsorption syndromes and in gluten related disorders. Characteristic movement disorders are key features of acquired hepatocerebral degeneration and of Whipple disease. Multiple types of neuropathy can be found in association with hepatitis, inflammatory bowel disease and gluten related disorders.


Hepatic failure Hepatitis Pancreatitis Inflammatory bowel disease Celiac disease Whipple disease Gluten ataxia Central nervous system Peripheral nervous system 


Compliance with Ethics Guidelines

Conflict of Interest

José M. Ferro and Sofia Oliveira declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Neurosciences, Service of Neurology, Hospital de Santa MariaUniversity of LisbonLisboaPortugal
  2. 2.Department of NeurologyHospital da LuzLisbonPortugal

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