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Neurology of Rheumatologic Disorders

  • Neurology of Systemic Disease (J Biller, Section Editor)
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Abstract

Rheumatologic diseases encompass autoimmune and inflammatory disorders of the joints and soft tissues that often involve multiple organ systems, including the central and peripheral nervous systems. Common features include constitutional symptoms, arthralgia and arthritis, myalgia, and sicca symptoms. Neurological manifestations may present in patients with preexisting rheumatologic diagnoses, occur concurrently with systemic signs and symptoms, or precede systemic manifestations by months to years. Rheumatic disorders presenting as neurological syndromes may pose diagnostic challenges. Advances in immunosuppressive treatment of rheumatologic disease have expanded the treatment armamentarium. However, serious neurotoxic effects have been reported with both old and newer agents. Familiarity with neurological manifestations of rheumatologic diseases, diagnosis, and potential nervous system consequences of treatment is important for rapid diagnosis and appropriate intervention. This article briefly reviews the diverse neurological manifestations and key clinical features of rheumatic disorders and the potential neurological complications of agents commonly used for treatment.

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Acknowledgment

We thank Rania Nouh for providing us with the illustration for this review.

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Amre Nouh, Olimpia Carbunar, and Sean Ruland declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Department of Neurology, Maguire 2700 Building 105, Loyola University Medical Center, Stritch School of Medicine, 2160 S. First Ave, Maywood, IL, 60153, USA

    Amre Nouh & Sean Ruland

  2. Department of Neurology, Cleveland Clinic of Florida, 2950 Cleveland Clinic Blvd, Weston, FL, 33331, USA

    Olimpia Carbunar

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  1. Amre Nouh
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Correspondence to Sean Ruland.

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This article is part of the Topical Collection on Neurology of Systemic Disease

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Nouh, A., Carbunar, O. & Ruland, S. Neurology of Rheumatologic Disorders. Curr Neurol Neurosci Rep 14, 456 (2014). https://doi.org/10.1007/s11910-014-0456-6

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