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Diagnosis and Treatment of Arterial Dissections

  • Stroke (H Adams, Section Editor)
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Abstract

Dissections of the cervical and intracranial vessels represent an important source of stroke in those less than 50 years of age. This can occur spontaneously or following trauma, minor or major. Rapid diagnosis is essential to limit subsequent sequelae and modern computed tomographic angiography represents an appropriately sensitive modality. Treatment must be individualized to the patient and can consist of an antiplatelet regimen, anticoagulation, or endovascular intervention. No evidence demonstrates superiority of either medical modality and even aspirin alone may be efficacious. Consideration should be given to this in the multi-trauma population in which more aggressive anticoagulation is contraindicated. In addition, thrombolytic administration should not be withheld would it otherwise be indicated. Endovascular intervention is reserved for those with hemodynamically significant narrowing, enlarging pseudoaneurysms, fistulas formation, or subarachnoid hemorrhage.

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References

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  1. Putaala J, Metso AJ, Metso TM, et al. Analysis of 1008 consecutive patients aged 15 to 49 with first-ever ischemic stroke: the Helsinki Young Stroke Registry. Stroke. 2009;40:1195–203. doi:10.1161/STROKEAHA.108.529883.

    Article  PubMed  Google Scholar 

  2. Stence NV, Fenton LZ, Goldenberg NA, et al. Craniocervical arterial dissection in children: diagnosis and treatment. Curr Treat Options Neurol. 2011;13:636–48. doi:10.1007/s11940-011-0149-2.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Lee VH, Brown Jr RD, Mandrekar JN, Mokri B. Incidence and outcome of cervical artery dissection: a population-based study. Neurology. 2006;67:1809–12. doi:10.1212/01.wnl.0000244486.30455.71.

    Article  PubMed  Google Scholar 

  4. Schievink WI, Mokri B, Whisnant JP. Internal carotid artery dissection in a community. Rochester, Minnesota, 1987-1992. Stroke. 1993;24:1678–80.

    Article  CAS  PubMed  Google Scholar 

  5. Giroud M, Fayolle H, Andre N, et al. Incidence of internal carotid artery dissection in the community of Dijon. J Neurol Neurosurg Psychiatry. 1994;57:1443.

    Article  CAS  PubMed  Google Scholar 

  6. Smith WS, Johnston SC, Skalabrin EJ, et al. Spinal manipulative therapy is an independent risk factor for vertebral artery dissection. Neurology. 2003;60:1424–8.

    Article  CAS  PubMed  Google Scholar 

  7. Albuquerque FC, Hu YC, Dashti SR, et al. Craniocervical arterial dissections as sequelae of chiropractic manipulation: patterns of injury and management. J Neurosurg. 2011;115:1197–205. doi:10.3171/2011.8.JNS111212.

    Article  PubMed  Google Scholar 

  8. Engelter ST, Grond-Ginsbach C, Metso TM, et al. Cervical artery dissection: trauma and other potential mechanical trigger events. Neurology. 2013;80:1950–7. doi:10.1212/WNL.0b013e318293e2eb.

    Article  PubMed  Google Scholar 

  9. Grau AJ, Buggle F, Ziegler C, et al. Association between acute cerebrovascular ischemia and chronic and recurrent infection. Stroke. 1997;28:1724–9.

    Article  CAS  PubMed  Google Scholar 

  10. Ringer AJ, Matern E, Parikh S, Levine NB. Screening for blunt cerebrovascular injury: selection criteria for use of angiography. J Neurosurg. 2010;112:1146–9. doi:10.3171/2009.6.jns08416.

    Article  PubMed  Google Scholar 

  11. Debette S, Grond-Ginsbach C, Bodenant M, et al. Differential features of carotid and vertebral artery dissections: the CADISP Study. Neurology. 2011;77:1174–81. doi:10.1212/WNL.0b013e31822f03fc.

    Article  CAS  PubMed  Google Scholar 

  12. von Babo M, De Marchis GM, Sarikaya H, et al. Differences and similarities between spontaneous dissections of the internal carotid artery and the vertebral artery. Stroke. 2013;44:1537–42. doi:10.1161/STROKEAHA.113.001057.

    Article  Google Scholar 

  13. Gottesman RF, Sharma P, Robinson KA, et al. Clinical characteristics of symptomatic vertebral artery dissection: a systematic review. Neurologist. 2012;18:245–54. doi:10.1097/NRL.0b013e31826754e1.

    Article  PubMed  Google Scholar 

  14. Yaghi S, Maalouf N, Keyrouz SG. Cervical artery dissection: risk factors, treatment, and outcome: a 5-year experience from a tertiary care center. Int J Neurosci. 2012;122:40–4. doi:10.3109/00207454.2011.622453.

    Article  PubMed  Google Scholar 

  15. Debette S, Metso T, Pezzini A, et al. Association of Vascular risk factors with cervical artery dissection and ischemic stroke in young adults. Circulation. 2011;123:1537–44. doi:10.1161/CIRCULATIONAHA.110.000125.

    Article  CAS  PubMed  Google Scholar 

  16. Chandra A, Suliman A, Angle N. Spontaneous dissection of the carotid and vertebral arteries: the 10-year USCD experience. Ann Vasc Surg. 2007;21:178–85. doi:10.1016/j.avsg.2006.10.020.

    Article  PubMed  Google Scholar 

  17. Sarraj A, Medrek S, Albright K, et al. Posterior circulation stroke is associated with prolonged door-to-needle time. Int J Stroke. 2013. doi:10.1111/j.1747-4949.2012.00952.x.

    Google Scholar 

  18. Arnold M, Kurmann R, Galimanis A, et al. Differences in demographic characteristics and risk factors in patients with spontaneous vertebral artery dissections with and without ischemic events. Stroke. 2010;41:802–4. doi:10.1161/STROKEAHA.109.570655.

    Article  PubMed  Google Scholar 

  19. Jauch EC, Saver JL, Adams Jr HP, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44:870–947. doi:10.1161/STR.0b013e318284056a.

    Article  PubMed  Google Scholar 

  20. Berne JD, Reuland KS, Villarreal DH, et al. Sixteen-slice multi-detector computed tomographic angiography improves the accuracy of screening for blunt cerebrovascular injury. J Trauma. 2006;60:1204–9. doi:10.1097/01.ta.0000220435.55791.ce. discussion 1209–10.

    Article  PubMed  Google Scholar 

  21. Hoit DA, Schirmer CM, Weller SJ, et al. Angiographic detection of carotid and vertebral arterial injury in the high-energy blunt trauma patient. J Spinal Disord Tech. 2008;21:259–66. doi:10.1097/BSD.0b013e318141fce8.

    Article  PubMed  Google Scholar 

  22. Miller PR, Fabian TC, Croce MA, et al. Prospective screening for blunt cerebrovascular injuries: analysis of diagnostic modalities and outcomes. Ann Surg. 2002;236:386–93. doi:10.1097/01.SLA.0000027174.01008.A0. discussion 393–385.

    Article  PubMed  Google Scholar 

  23. Biffl WL, Egglin T, Benedetto B, et al. Sixteen-slice computed tomographic angiography is a reliable noninvasive screening test for clinically significant blunt cerebrovascular injuries. J Trauma. 2006;60:745–51. doi:10.1097/01.ta.0000204034.94034.c4. discussion 751–42.

    Article  PubMed  Google Scholar 

  24. Biffl WL, Moore EE, Elliott JP, et al. The devastating potential of blunt vertebral arterial injuries. Ann Surg. 2000;231:672–81.

    Article  CAS  PubMed  Google Scholar 

  25. Griessenauer CJ, Fleming JB, Richards BF, et al. Timing and mechanism of ischemic stroke due to extracranial blunt traumatic cerebrovascular injury. J Neurosurg. 2013;118:397–404. doi:10.3171/2012.11.JNS121038.

    Article  PubMed  Google Scholar 

  26. Mayberry JC, Brown CV, Mullins RJ, Velmahos GC. Blunt carotid artery injury: the futility of aggressive screening and diagnosis. Arch Surg. 2004;139:609–12. doi:10.1001/archsurg.139.6.609. discussion 612–603.

    Article  PubMed  Google Scholar 

  27. Stein DM, Boswell S, Sliker CW, et al. Blunt cerebrovascular injuries: does treatment always matter? J Trauma. 2009;66:132–43. doi:10.1097/TA.0b013e318142d146. discussion 143–134.

    Article  PubMed  Google Scholar 

  28. Chen CJ, Tseng YC, Lee TH, et al. Multisection CT angiography compared with catheter angiography in diagnosing vertebral artery dissection. Am J Neuroradiol. 2004;25:769–74.

    PubMed  Google Scholar 

  29. Elijovich L, Kazmi K, Gauvrit JY, Law M. The emerging role of multidetector row CT angiography in the diagnosis of cervical arterial dissection: preliminary study. Neuroradiology. 2006;48:606–12. doi:10.1007/s00234-006-0100-5.

    Article  PubMed  Google Scholar 

  30. Houser OW, Mokri B, Sundt Jr TM, et al. Spontaneous cervical cephalic arterial dissection and its residuum: angiographic spectrum. Am J Neuroradiol. 1984;5:27–34.

    CAS  PubMed  Google Scholar 

  31. Sliker CW, Shanmuganathan K, Mirvis SE. Diagnosis of blunt cerebrovascular injuries with 16-mdct: accuracy of whole-body MDCT compared with neck MDCT angiography. Am J Roentgenol. 2008;190:790–9. doi:10.2214/AJR.07.2378.

    Article  Google Scholar 

  32. Zuber M, Meary E, Meder JF, Mas JL. Magnetic resonance imaging and dynamic CT scan in cervical artery dissections. Stroke. 1994;25:576–81.

    Article  CAS  PubMed  Google Scholar 

  33. Eastman AL, Muraliraj V, Sperry JL, Minei JP. CTA-based screening reduces time to diagnosis and stroke rate in blunt cervical vascular injury. J Trauma. 2009;67:551–6. doi:10.1097/TA.0b013e3181b84408. discussion 555–6.

    Article  PubMed  Google Scholar 

  34. Chen WL, Chern CH, Wu YL, Lee CH. Vertebral artery dissection and cerebellar infarction following chiropractic manipulation. Emerg Med J. 2006;23:e1. doi:10.1136/emj.2004.015636.

    Article  PubMed  Google Scholar 

  35. Cothren CC, Biffl WL, Moore EE, et al. Treatment for blunt cerebrovascular injuries: equivalence of anticoagulation and antiplatelet agents. Arch Surg. 2009;144:685–90. doi:10.1001/archsurg.2009.111.

    Article  CAS  PubMed  Google Scholar 

  36. Cothren CC, Moore EE, Biffl WL, et al. Anticoagulation is the gold standard therapy for blunt carotid injuries to reduce stroke rate. Arch Surg. 2004;139:540–5. doi:10.1001/archsurg.139.5.540. discussion 545–6.

    Article  PubMed  Google Scholar 

  37. Engelter ST, Brandt T, Debette S, et al. Antiplatelets versus anticoagulation in cervical artery dissection. Stroke. 2007;38:2605–11. doi:10.1161/STROKEAHA.107.489666.

    Article  PubMed  Google Scholar 

  38. Georgiadis D, Arnold M, von Buedingen HC, et al. Aspirin vs anticoagulation in carotid artery dissection: a study of 298 patients. Neurology. 2009;72:1810–5. doi:10.1212/WNL.0b013e3181a2a50a.

    Article  CAS  PubMed  Google Scholar 

  39. •• Kennedy F, Lanfranconi S, Hicks C, et al. Antiplatelets vs anticoagulation for dissection: CADISS nonrandomized arm and meta-analysis. Neurology. 2012;79:686–9. doi:10.1212/WNL.0b013e318264e36b. Demonstrates equal effectiveness of both antiplatelet and anticoagulation in arterial dissections.

    Article  CAS  PubMed  Google Scholar 

  40. Lyrer P, Engelter S. Antithrombotic drugs for carotid artery dissection. Cochrane Database Syst Rev. 2010; CD000255. doi: 10.1002/14651858.CD000255.pub2.

  41. Harrigan MR, Hadley MN, Dhall SS, et al. Management of vertebral artery injuries following nonpenetrating cervical trauma. Neurosurgery. 2013;72 Suppl 2:234–43. doi:10.1227/NEU.0b013e31827765f5.

    Article  PubMed  Google Scholar 

  42. • Engelter ST, Dallongeville J, Kloss M, et al. Thrombolysis in cervical artery dissection--data from the cervical artery dissection and ischaemic stroke patients (CADISP) database. Eur J Neurol. 2012;19:1199–206. doi:10.1111/j.1468-1331.2012.03704.x. Demonstrates safety of thrombolysis in this patient population.

    Article  CAS  PubMed  Google Scholar 

  43. Engelter ST, Rutgers MP, Hatz F, et al. Intravenous thrombolysis in stroke attributable to cervical artery dissection. Stroke. 2009;40:3772–6. doi:10.1161/STROKEAHA.109.555953.

    Article  PubMed  Google Scholar 

  44. Georgiadis D, Lanczik O, Schwab S, et al. IV thrombolysis in patients with acute stroke due to spontaneous carotid dissection. Neurology. 2005;64:1612–4. doi:10.1212/01.WNL.0000159548.45013.C1.

    Article  CAS  PubMed  Google Scholar 

  45. Zinkstok SM, Vergouwen MD, Engelter ST, et al. Safety and functional outcome of thrombolysis in dissection-related ischemic stroke: a meta-analysis of individual patient data. Stroke. 2011;42:2515–20. doi:10.1161/STROKEAHA.111.617282.

    Article  PubMed  Google Scholar 

  46. Cohen JE, Ben-Hur T, Rajz G, et al. Endovascular stent-assisted angioplasty in the management of traumatic internal carotid artery dissections. Stroke. 2005;36:e45–7. doi:10.1161/01.STR.0000158910.08024.7f.

    Article  PubMed  Google Scholar 

  47. Cohen JE, Gomori JM, Grigoriadis S, et al. Intra-arterial thrombolysis and stent placement for traumatic carotid dissection with subsequent stroke: a combined, simultaneous endovascular approach. J Neurol Sci. 2008;269:172–5. doi:10.1016/j.jns.2007.12.013.

    Article  PubMed  Google Scholar 

  48. Cohen JE, Gomori JM, Itshayek E, et al. Single-center experience on endovascular reconstruction of traumatic internal carotid artery dissections. J Trauma Acute Care Surg. 2012;72:216–21. doi:10.1097/TA.0b013e31823f630a.

    PubMed  Google Scholar 

  49. Cohen JE, Gomori JM, Umansky F. Endovascular management of symptomatic vertebral artery dissection achieved using stent angioplasty and emboli protection device. Neurol Res. 2003;25:418–22.

    Article  PubMed  Google Scholar 

  50. Edgell RC, Abou-Chebl A, Yadav JS. Endovascular management of spontaneous carotid artery dissection. J Vasc Surg. 2005;42:854–60. doi:10.1016/j.jvs2005.06.029. discussion 860.

    Article  PubMed  Google Scholar 

  51. Fava M, Meneses L, Loyola S, et al. Carotid artery dissection: endovascular treatment. report of 12 patients. Catheter Cardiovasc Interv. 2008;71:694–700.

    Article  PubMed  Google Scholar 

  52. Lavallee PC, Mazighi M, Saint-Maurice JP, et al. Stent-assisted endovascular thrombolysis versus intravenous thrombolysis in internal carotid artery dissection with tandem internal carotid and middle cerebral artery occlusion. Stroke. 2007;38:2270–4. doi:10.1161/STROKEAHA.106.481093.

    Article  PubMed  Google Scholar 

  53. • Seth R, Obuchowski AM, Zoarski GH. Endovascular repair of traumatic cervical internal carotid artery injuries: a safe and effective treatment option. Am J Neuroradiol. 2013;34:1219–26. doi:10.3174/ajnr.A3337. Demonstrates safety and efficacy of endovascular repair of arterial dissections in a select population.

    Article  CAS  PubMed  Google Scholar 

  54. Ansari SA, Thompson BG, Gemmete JJ, Gandhi D. Endovascular treatment of distal cervical and intracranial dissections with the neuroform stent. Neurosurgery. 2008;62:636–46. doi:10.1227/01.NEU.0000311350.25281.6B. discussion 636–46.

    Article  PubMed  Google Scholar 

  55. Kansagra AP, Cooke DL, English JD, et al. Current trends in endovascular management of traumatic cerebrovascular injury. J Neurointervention Surg. 2013. doi:10.1136/neurintsurg-2012-010605.

    Google Scholar 

  56. Hassan AE, Zacharatos H, Rodriguez GJ, et al. Long-term clinical and angiographic outcomes in patients with spontaneous cervico-cranial arterial dissections treated with stent placement. J Neuroimaging. 2012;22:384–93. doi:10.1111/j.1552-6569.2012.00724.x.

    Article  PubMed  Google Scholar 

  57. Pham MH, Rahme RJ, Arnaout O, et al. Endovascular stenting of extracranial carotid and vertebral artery dissections: a systematic review of the literature. Neurosurgery. 2011;68:856–66. doi:10.1227/NEU.0b013e318209ce03. discussion 866.

    PubMed  Google Scholar 

  58. de Barros Faria M, Castro RN, Lundquist J, et al. The role of the pipeline embolization device for the treatment of dissecting intracranial aneurysms. Am J Neuroradiol. 2011;32:2192–5. doi:10.3174/ajnr.A2671.

    Article  PubMed  Google Scholar 

  59. Ducruet AF, Crowley RW, Albuquerque FC, McDougall CG. Reconstructive endovascular treatment of a ruptured vertebral artery dissecting aneurysm using the pipeline embolization device. J Neurointervention Surg. 2013;5:e20. doi:10.1136/neurintsurg-2012-010358.

    Article  Google Scholar 

  60. Fields JD, Lutsep HL, Rymer MR, et al. Endovascular mechanical thrombectomy for the treatment of acute ischemic stroke due to arterial dissection. Interv Neuroradiol. 2012;18:74–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  61. Ioannidis I, Nasis N, Andreou A. Endovascular treatment of ruptured dissecting posterior inferior cerebellar artery aneurysms. Interv Neuroradiol. 2012;18:442–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  62. Ishihara H, Tateshima S, Jahan R, et al. Endovascular treatment of ruptured dissecting aneurysms of the posterior inferior cerebellar artery. J Neurointervention Surg. 2012;5:557–561. doi:10.1136/neurintsurg-2012-010500.

    Google Scholar 

  63. Kashiwazaki D, Ushikoshi S, Asano T, et al. Long-term clinical and radiological results of endovascular internal trapping in vertebral artery dissection. Neuroradiology. 2013;55:201–6. doi:10.1007/s00234-012-1114-9.

    Article  PubMed  Google Scholar 

  64. Kim BM, Shin YS, Kim SH, et al. Incidence and risk factors of recurrence after endovascular treatment of intracranial vertebrobasilar dissecting aneurysms. Stroke. 2011;42:2425–30. doi:10.1161/strokeaha.111.617381.

    Article  PubMed  Google Scholar 

  65. Kocak B, Tureci E, Kizilkilic O, et al. Dissecting aneurysms of posterior communicating artery itself: anatomical, diagnostic, clinical, and therapeutical considerations. Neuroradiology. 2013;55:1103–12. doi:10.1007/s00234-013-1212-3.

    Article  PubMed  Google Scholar 

  66. Lama S, Dolati P, Sutherland GR. Controversy in the management of lenticulostriate artery dissecting aneurysm: a case report and review of the literature. World Neurosurg. 2012. doi:10.1016/j.wneu.2012.12.006.

    Google Scholar 

  67. Wang H, Du R, Stary J, et al. Dissecting aneurysms of the posterior cerebral artery: current endovascular/surgical evaluation and treatment strategies. Neurosurgery. 2012;70:1581–8. doi:10.1227/NEU.0b013e31824c00f4. discussion 1588.

    Article  PubMed  Google Scholar 

  68. Yeung TW, Lai V, Lau HY, et al. Long-term outcome of endovascular reconstruction with the pipeline embolization device in the management of unruptured dissecting aneurysms of the intracranial vertebral artery. J Neurosurg. 2012;116:882–7. doi:10.3171/2011.12.JNS111514.

    Article  PubMed  Google Scholar 

  69. Ali MS, Amenta PS, Starke RM, et al. Intracranial vertebral artery dissections: evolving perspectives. Interv Neuroradiol. 2012;18:469–83.

    CAS  PubMed Central  PubMed  Google Scholar 

  70. Narata AP, Yilmaz H, Schaller K, et al. Flow-diverting stent for ruptured intracranial dissecting aneurysm of vertebral artery. Neurosurgery. 2012;70:982–8. doi:10.1227/NEU.0b013e318236715e. discussion 988–9.

    Article  PubMed  Google Scholar 

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Ricky Medel declares that he has no conflict of interest. Robert M. Starke declares that he has no conflict of interest. Edison P. Valle-Gil declares that he has no conflict of interest. Sheryl Martin-Schild declares that she has no conflict of interest. Ramy El Khoury declares that he has no conflict of interest. Aaron S. Dumont declares that he has no conflict of interest.

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Medel, R., Starke, R.M., Valle-Giler, E.P. et al. Diagnosis and Treatment of Arterial Dissections. Curr Neurol Neurosci Rep 14, 419 (2014). https://doi.org/10.1007/s11910-013-0419-3

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