• Ali-Reza Fathi
  • Ulrich Roelcke
Neuro-Oncology (LE Abrey, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Neuro-Oncology


Meningiomas represent the most common primary brain tumor and comprise 3 World Health Organization (WHO) grades, the most frequent being WHO grade I (90 %). Surgery is mandatory to establish the diagnosis and to remove the tumor; however, complete resection can be achieved in only <50 % of patients. Depending on the extent of resection, tumor location and the WHO grade radiation therapy can be applied. The issue of systemic treatment such as chemotherapy or targeted therapy (eg, somatostatin receptors, antiangiogenic agents) is yet not solved, particularly as current data are derived from small uncontrolled series in patients with long-standing disease and after several pretreatments. A more thorough understanding of molecular genetics, signaling pathways and prognostic factors in meningiomas should lead to the design of studies which stratify according to these factors. These studies have to be conducted in newly diagnosed patients after incomplete resection and in tumors of WHO grade II and III.


Meningioma Benign brain tumor Skull base Neurofibromatosis Diagnosis Imaging Pathology Molecular genetics Neurosurgery Surgery Radiation therapy Radiosurgery Somatostatin receptors Chemotherapy Targeted therapy 



Ali-Reza Fathi declares no conflict of interest. Ulrich Roelcke declares no conflict of interest.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of NeurosurgeryCantonal HospitalAarauSwitzerland
  2. 2.Department of Neurology & Brain Tumor CenterCantonal HospitalAarauSwitzerland
  3. 3.University of Basel, School of MedicineBaselSwitzerland

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