Current Neurology and Neuroscience Reports

, Volume 12, Issue 5, pp 560–569

Biomarkers in Traumatic Brain Injury

Neurotrauma (J Levine, Section Editor)

DOI: 10.1007/s11910-012-0301-8

Cite this article as:
Sharma, R. & Laskowitz, D.T. Curr Neurol Neurosci Rep (2012) 12: 560. doi:10.1007/s11910-012-0301-8


Traumatic brain injury (TBI) is a common cause of neurological morbidity globally, and neurologic sequelae may occur even in the setting of mild injury. At present, the tools that guide diagnostic and prognostic evaluation of patients who suffer from TBI remain limited, especially for prehospital evaluation. Biomarkers of brain injury hold promise in facilitating early management and triage decisions in the civilian and military settings. The identification of biomarkers of brain injury may also be helpful in guiding end-of-life decision making and may facilitate the design of neuroprotective trials.


Traumatic brain injury Biomarkers Glasgow Coma Score S100B GFAP NSE Alpha II spectrin End-of-life decisions Clinical trials Diffuse axonal injury Hematoma Concussion Inflammation 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.School of MedicineDuke University Medical CenterDurhamUSA
  2. 2.Department of Medicine (Neurology)Duke University Medical CenterDurhamUSA

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