Current Neurology and Neuroscience Reports

, Volume 12, Issue 3, pp 325–333 | Cite as

What We Know about the Generation of Nystagmus and Other Ocular Oscillations: Are We Closer to Identifying Therapeutic Targets?

  • Rebecca Jane McLeanEmail author
  • Irene Gottlob
  • Frank Antony Proudlock
Neuro-Ophthalmology (G Plant, Section Editor)


Mechanisms underlying acquired nystagmus are better understood than those leading to infantile nystagmus. Accordingly, further progress has been made in the development of effective therapies for acquired nystagmus, mainly through pharmacological interventions. Some of these therapies have been developed under the guidance of findings from experimental animal models. Although mechanisms behind infantile nystagmus are less understood, progress has been made in determining the genetic basis of nystagmus and characterizing associated sensory deficits. Pharmacological, surgical, and other treatments options for infantile nystagmus are now emerging. Further investigations are required for all forms of nystagmus to produce high-quality evidence, such as randomized controlled trials, upon which clinicians can make appropriate treatment decisions.


Nystagmus Acquired Infantile Treatment Mechanisms Pharmacological Ocular oscillations 



Conflicts of interest: R.J. McLean: has received grant support from the Ulverscroft Foundation; I. Gottlob: has received grant support from the Ulverscroft Foundation; F.A. Proudlock: has received grant support from the Ulverscroft Foundation.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Rebecca Jane McLean
    • 1
    Email author
  • Irene Gottlob
    • 1
  • Frank Antony Proudlock
    • 1
  1. 1.Robert Kilpatrick Clinical Sciences Building, Leicester Royal InfirmaryOphthalmology Group, University of Leicester, Faculty of Medicine & Biological SciencesLeicesterUK

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