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Recent advances in the genetics of dementia with Lewy bodies

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Abstract

In the past few years, mutations have been identified in the genes encoding α-synuclein, leucine-rich repeat kinase 2, and glucocerebrosidase in some patients with dementia with Lewy bodies (DLB). Furthermore, a novel locus for familial DLB has been mapped to chromosome 2q35-q36. Collectively, these discoveries highlight a substantial overlap between the known genetic determinants of Parkinson’s disease and DLB, as well as the presence of profound etiologic heterogeneity in Lewy body disorders.

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  1. Department of Clinical Genetics, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands

    Vincenzo Bonifati

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  1. Vincenzo Bonifati
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Correspondence to Vincenzo Bonifati.

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Bonifati, V. Recent advances in the genetics of dementia with Lewy bodies. Curr Neurol Neurosci Rep 8, 187–189 (2008). https://doi.org/10.1007/s11910-008-0030-1

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  • DOI: https://doi.org/10.1007/s11910-008-0030-1

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