Abstract
Genome-wide association studies have already yielded great results. The success of this method in several common diseases leaves little doubt that it will aid in deciphering the genetic bases of the most common and devastating neurodegenerative disorders.
Article PDF
Similar content being viewed by others
References and Recommended Reading
Palmer LJ, Cardon LR: Shaking the tree: mapping complex disease genes with linkage disequilibrium. Lancet 2005, 366:1223–1234.
Balding DJ: A tutorial on statistical methods for population association studies. Nat Rev Genet 2006, 7:781–791.
Sladek R, Rocheleau G, Rung J, et al.: A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007, 445:881–885.
Rioux JD, Xavier RJ, Taylor KD, et al.: Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 2007, 39:596–604.
Wellcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007, 447:661–678.
Easton DF, Pooley KA, Dunning AM, et al.: Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 2007, 447:1087–1093.
Maraganore DM, de Andrade M, Lesnick TG, et al.: Highresolution whole-genome association study of Parkinson disease. Am J Hum Genet 2005, 77:685–693.
Fung HC, Scholz S, Matarin M, et al.: Genome-wide genotyping in Parkinson’s disease and neurologically normal controls: first stage analysis and public release of data. Lancet Neurol 2006, 5:911–916.
Schymick JC, Scholz SW, Fung HC, et al.: Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. Lancet Neurol 2007, 6:322–328.
Elbaz A, Nelson LM, Payami H, et al.: Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson’s disease: a large-scale international study. Lancet Neurol 2006, 5:917–923.
Myers RH: Considerations for genomewide association studies in Parkinson disease. Am J Hum Genet 2006, 78:1081–1082.
Coon KD, Myers AJ, Craig DW, et al.: A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer’s disease. J Clin Psychiatry 2007, 68:613–618.
Reiman EM, Webster JA, Myers AJ, et al.: GAB2 alleles modify alzheimer’s risk in APOE-e4 carriers. Neuron 2007, 54:713–720.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Open Access This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License ( https://creativecommons.org/licenses/by-nc/2.0 ), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
About this article
Cite this article
Bonifati, V. Common neurodegenerative diseases: Dissection by genome-wide association. Curr Neurol Neurosci Rep 7, 425–427 (2007). https://doi.org/10.1007/s11910-007-0065-8
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11910-007-0065-8