Skip to main content

Advertisement

Log in

Gene therapy: Novel treatments for polyneuropathy and chronic pain

  • Invited Commentary
  • Published:
Current Neurology and Neuroscience Reports Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Friedmann T, Roblin R: Gene therapy for human genetic disease? Science 1972, 175:949–955.

    Article  PubMed  CAS  Google Scholar 

  2. Davidson BL, Breakefield XO: Viral vectors for gene delivery to the nervous system. Nat Rev Neurosci 2003, 4:353–364.

    Article  PubMed  CAS  Google Scholar 

  3. Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, et al.: Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 2000, 288:669–672.

    Article  PubMed  CAS  Google Scholar 

  4. Apfel SC: Is the therapeutic application of neurotrophic factors dead? Ann Neurol 2002, 51:8–11.

    Article  PubMed  Google Scholar 

  5. Apfel SC: Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold? Int Rev Neurobiol 2002, 50:393–413.

    Article  PubMed  CAS  Google Scholar 

  6. Roizman B, Sears A: Herpes simplex viruses and their replication. In Fields Virology, vol 2. Edited by Fields BN, Knipe DM, Howley PM, et al. Philadelphia: Lippincott-Raven; 1996:2231–2295.

    Google Scholar 

  7. Fink DJ, DeLuca NA, Glorioso JC: Gene transfer to neurons using herpes simplex virus-based vectors. Annu Rev Neurosci 1996, 19:265–287.

    Article  PubMed  CAS  Google Scholar 

  8. Fink DJ, Glorioso JC: Engineering herpes simplex virus vectors for gene transfer to neurons. Nat Med 1997, 3:357–359.

    Article  PubMed  CAS  Google Scholar 

  9. Mata M, Glorioso JC, Fink DJ: Targeted gene delivery to the nervous system using herpes simplex virus vectors. Physiol Behav 2002, 77:483–488.

    Article  PubMed  CAS  Google Scholar 

  10. Chattopadhyay M, Wolfe D, Huang S, et al.: In vivo gene therapy of pyridoxine-induced neuropathy by HSV-mediated gene transfer of neurotrophin-3. Ann Neurol 2002, 51:19–27.

    Article  PubMed  CAS  Google Scholar 

  11. Chattopadhyay M, Goss J, Lacomis D, et al.: Protective effect of HSV-mediated gene transfer of nerve growth factor in pyridoxine neuropathy demonstrates functional activity of trkA receptors in large sensory neurons of adult animals. Eur J Neurosci 2003, 17:732–740.

    Article  PubMed  Google Scholar 

  12. Goss JR, Goins WF, Lacomis D, et al.: Herpes simplex-mediated gene transfer of nerve growth factor protects against peripheral neruropathy in streptozotocin-induced diabetes in the mouse. Diabetes 2002, 51:2227–2232.

    Article  PubMed  CAS  Google Scholar 

  13. Chattopadhyay M, Goins W, Glorioso JC, et al.: HSV-mediated gene transfer of NGF in cisplatin neuropathy. Mol Ther 2002, 5:S244.

    Google Scholar 

  14. Braz J, Beaufour C, Coutaux A, et al.: Therapeutic efficacy in experimental polyarthritis of viral-driven enkephalin overproduction in sensory neurons. J Neurosci 2001, 21:7881–7888.

    PubMed  CAS  Google Scholar 

  15. Goss JR, Mata M, Goins WF, et al.: Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion. Gene Ther 2001, 8:551–556.

    Article  PubMed  CAS  Google Scholar 

  16. Hao S, Mata M, Goins W, et al.: Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect. Pain 2003, 102:135–142.

    Article  PubMed  CAS  Google Scholar 

  17. Goss JR, Harley CF, Mata M, et al.: Herpes vector-mediated expression of proenkephalin reduces pain-related behavior in a model of bone cancer pain. Ann Neurol 2002, 52:662–665.

    Article  PubMed  CAS  Google Scholar 

  18. Hao S, Mata M, Wolfe D, et al.: HSV-mediated gene transfer of the glial cell derived neurotrophic factor (GDNF) provides an anti-allodynic effect in neuropathic pain. Mol Ther 2004, in press.

  19. Markert JM, Medlock MD, Rabkin SD, et al.: Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial. Gene Ther 2000, 7:867–874.

    Article  PubMed  CAS  Google Scholar 

  20. Rampling R, Cruickshank G, Papanastassiou V, et al.: Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma. Gene Ther 2000, 7:859–866.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mata, M., Glorioso, J.C. & Fink, D.J. Gene therapy: Novel treatments for polyneuropathy and chronic pain. Curr Neurol Neurosci Rep 4, 1–2 (2004). https://doi.org/10.1007/s11910-004-0001-0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11910-004-0001-0

Keywords

Navigation