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Current Neurology and Neuroscience Reports

, Volume 3, Issue 1, pp 86–92 | Cite as

Medication-induced peripheral neuropathy

  • Louis H. Weimer
Article

Abstract

Although not very common, medication-induced neuropathy is a treatable condition and, therefore, is important to identify. Medications continue to grow in number and expand in usage; consequently, toxic neuropathy continues to be relevant to neurologists. Many agents have toxicities that are tolerated because the treatments are necessary, such as therapies for HIV and malignancy. Additional agents to prevent or ameliorate the toxic neuropathy are being sought and trials are ongoing. Certain patients, however, may be at high risk for peripheral nerve toxicity due to genetic factors or another underlying neuropathy. Newer drug-delivery methods, such as viral transfection, may produce less toxicity in the future. The underlying pathomechanisms remain incompletely elucidated; however, apoptosis is emerging as an important final pathway in some forms of toxic neuropathy. Although most cases demonstrate acute or subacute onset after exposure, recent experiences with statin drugs raise the possibility of occult toxic causes of chronic idiopathic neuropathy.

Keywords

Neuropathy Nerve Growth Factor Peripheral Neuropathy Thalidomide Suramin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Current Science Inc. 2003

Authors and Affiliations

  • Louis H. Weimer
    • 1
  1. 1.Neurological Institute of New YorkNew YorkUSA

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