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Clostridioides difficile–Associated Diarrhea: Infection Prevention Unknowns and Evolving Risk Reduction Strategies

  • Healthcare Associated Infections (G. Bearman and D. Morgan, Section Editors)
  • Published:
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Abstract

Purpose of Review

New controversies in the diagnosis and prevention of Clostridiodes difficile are challenging and at times changing infection control practice at many medical centers.

Recent Findings

Molecular epidemiologic studies are changing our understanding of C. difficile and its spectrum of disease. C. difficile as a hospital-acquired infection is likely largely overdiagnosed given overly sensitive molecular testing and widespread colonization of ill or debilitated patients.

Summary

Clostridiodes difficile infection continues to challenge infection prevention programs. Shifts in our understanding of the epidemiology of this organism and its spectrum of clinical presentations are changing the approach to prevention efforts. Nevertheless, cleanliness of the healthcare environment and antimicrobial stewardship remain core risk reduction strategies. Other strategies such as screening and isolation are inciting controversy. The optimal infection prevention strategies for C. difficile remain the subject of intense study and debate.

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  1. Virginia Commonwealth University Medical Center, 1300 E. Marshall Street, Richmond, VA, 23298-0019, USA

    Michelle Doll, Michele Fleming, Michael P. Stevens & Gonzalo Bearman

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Correspondence to Michelle Doll.

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Kaila Cooper and Michael Stevens declare that they have no conflict of interest.

Michelle Doll and Gonzalo Bearman have received grants from Molnlycke Healthcare.

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Doll, M., Fleming, M., Stevens, M.P. et al. Clostridioides difficile–Associated Diarrhea: Infection Prevention Unknowns and Evolving Risk Reduction Strategies. Curr Infect Dis Rep 21, 1 (2019). https://doi.org/10.1007/s11908-019-0659-8

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