Neurological Complications and Sequelae of Ebola Virus Disease


Purpose of Review

The recent 2014–2016 outbreak of Ebola virus disease (EVD) has led to many discoveries regarding Ebola. Although neurological symptoms during EVD had been previously described, many reports since this outbreak have made clear that EVD can lead to neurological issues. This article will review the various neurological manifestations of EVD.

Recent Findings

Recently, many neurological symptoms have been described during acute EVD, including altered mental status, seizures, and meningoencephalitis, among others; survivors of EVD also may develop neurological sequelae, such as persistent headache and memory loss and can exhibit abnormalities on neurological exam. Additionally, it is now evident that in rare cases, survivors may experience relapses of EVD months after recovery, including the central nervous system (CNS).


EVD can result in many clinical neurological manifestations, both acutely and after recovery. Research is ongoing to further clarify the nature of Ebola in the CNS.

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Correspondence to Bridgette Jeanne Billioux.

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Billioux, B.J. Neurological Complications and Sequelae of Ebola Virus Disease. Curr Infect Dis Rep 19, 19 (2017).

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  • Ebola virus disease
  • Neurological sequelae
  • Viral persistence