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Risk Factors for Drug-Resistant Cap in Immunocompetent Patients

Current Infectious Disease Reports volume 19, Article number: 11 (2017) Cite this article

Abstract

Purpose of Review

The increase in drug-resistant community-acquired pneumonia (CAP) is an important problem all over the world. This article explores the current state of antimicrobial resistance of different bacteria that cause CAP and also assesses risk factors to identify those pathogens.

Recent Findings

In the last two decades, it has been documented that there is a significant increase in drug-resistant Streptococcus pneumoniae and other bacteria causing CAP. The most important risk factors are overuse of antibiotics, prior hospitalization, and lung comorbidities. The direct consequences can be severe, including prolonged stays in hospital, increased costs, and morbi-mortality. However, drug-resistant CAP declined after the introduction of the pneumococcal conjugate vaccine.

Summary

This review found an increase in resistance to the antibiotics used in CAP, and the risk factor can be used for identifying patients with drug-resistant CAP and initiate appropriate treatment. Judicious use of antibiotics and the development of effective new vaccines are needed.

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Affiliations

  1. Servicio de Medicina Respiratoria, Instituto Nacional Del Tórax and Unidad de Enfermedades Respiratorias, Facultad de Medicina Oriente, Universidad de Chile, J.M.Infante 717, Providencia, Santiago of Chile, Chile

    Francisco Arancibia

  2. Departamento de Medicina, Hospital Clínico U. de Chile, Universidad de Chile, Av. Independencia 1027, Independencia, Providencia, Santiago of Chile, Chile

    Mauricio Ruiz

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  1. Francisco Arancibia
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Arancibia, F., Ruiz, M. Risk Factors for Drug-Resistant Cap in Immunocompetent Patients. Curr Infect Dis Rep 19, 11 (2017). https://doi.org/10.1007/s11908-017-0565-x

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Keywords

  • Antimicrobial resistance
  • Antibiotic resistance mechanisms
  • Community-acquired pneumonia
  • Risk factors