Touchless Technologies for Decontamination in the Hospital: a Review of Hydrogen Peroxide and UV Devices


Reduction of microbial contamination of the hospital environment is a challenge, yet has potential impacts on infection prevention efforts. Fumigation and UV light devices for environmental cleaning have expanded into the health care setting with the goal of decontamination of difficult to clean or overlooked surfaces. In an era of increased scrutiny of hospital-acquired infections, increasingly, health care centers are adopting these “touchless” cleaning techniques as adjuncts to traditional manual cleaning. The evidence for improved clinical outcomes is lacking; yet, the experience with these devices continues to accumulate in the literature. We review the recently published data related to the use of hydrogen peroxide and UV light-based decontamination systems for cleaning of hospital rooms. Touchless cleaning technologies may provide an incremental benefit to standard practices by limiting cross-transmission of pathogens via environmental surfaces, though evidence of prevention of infections remains limited.


Reduction of microbial contamination in the hospital environment is an important component of an infection prevention strategy. This is especially true in an era of increased scrutiny on hospital-acquired infections and multidrug-resistant organisms. The burden of microbial contamination as identified in the literature depends on a variety of factors including culture methods, sites cultured, occupant characteristics, and cleaning practices used at the hospital; however, over 50 % of sites may remain untouched by conventional manual cleaning [1]. Flaws in traditional cleaning methods are more than aesthetic and can translate into very real patient risks. A patient admitted to a hospital room whose previous occupant had methicillin-resistant Staphylococcus aureus (MRSA), Clostridium difficile, or certain multidrug-resistant gram negative rods has a significantly increased risk of acquiring each of these pathogens [24]. Similar to many hospital-acquired infections, the absolute overall risk of acquisition remains low, though this may be of little comfort to patients who assume that a room is clean when they are admitted to it.

Touchless technologies attempt to overcome some of the deficiencies of manual cleaning by taking the human element out of the process. Touchless technologies encompass a wide range of products including self-disinfecting surfaces and fumigation methods. Self-disinfecting surfaces have been reviewed recently by Humphreys, and application in the clinical setting has been scantly reported in the literature to date [5].

Fumigation with gases or aerosolized compounds has long been employed as a decontamination strategy to protect food and water supplies [6]. More recent advances in delivery systems have allowed for the expansion of this technology to the health care system including patient care areas. Application of vapors for decontamination overcomes many of the limitations of traditional manual cleaning within the hospital environment, because of its ability to permeate or penetrate complex surfaces [7, 8], albeit with varying levels of uniformity [9]. While other gases such as chlorine dioxide and ozone are also potent decontamination agents, there is a decreased safety margin for both gases compared to hydrogen peroxide (HP) methods; limits of acceptable exposures in case of residual gas or room leakage are 1 ppm for HP compared to <0.1 ppm for chlorine dioxide and ozone [6, 8, 10, 11]. In addition, both chlorine dioxide and ozone require carefully controlled humidity and have corrosive properties that are problematic for hospital furnishings and equipment [6].

Thus, in general, hospitals using touchless technologies have used UV light and hydrogen peroxide, both of which have been reviewed in the literature previously [68, 12, 13]. However, as more health care centers gain experience with various devices, the body of evidence on these technologies continues to increase. We review the recently published data regarding UV light and hydrogen peroxide usage in cleaning the health care environment.

Search Strategy

PubMed was searched using the terms (UV-C OR UVC OR pulsed xenon OR UV light OR hydrogen peroxide) AND (cleaning OR disinfection OR infection OR decontamination). This search produced >7000 articles that were screened for relevance by title. Sixty-eight articles were selected as relevant to the use of HP or UV technologies in clinical settings; 47 of these were original research. Original research articles were further reviewed by abstract; bibliographies were also considered. Thirty-one studies published between 2012 and March 2015 were selected for full review, and 28 are included in the analysis below based on pertinence to application of UV/HP technologies in environmental cleaning of hospital rooms. Articles published prior to 2012 were selectively included in order to provide context to this review of the recent literature.

Killing Efficacy

UV light and HP systems have distinct properties (Table 1). In general, UV-based systems require less time and manual effort for set up and monitoring, at the cost of decreased efficacy of “in vitro” killing of bacteria.

Table 1 Comparison of hydrogen peroxide and UV light methods

Efficacy of UV light and HP touchless technologies are measured in two main ways: (1) in vitro experiments using carefully quantitated samples of experimentally placed bacteria and measuring log reductions in the colonies posttreatment and (2) “in vivo” experiments using actual patient rooms postdischarge. Surfaces are cultured before and after treatments to determine reduction in site contamination. It is important to note whether a reduction in contamination is being compared to a dirty room, or to the residual contamination in a room cleaned by standard methods. Some investigations employed both methods (Table 2). The devices and their corresponding studies are grouped in four main categories to facilitate the organization of the discussion that follows; however, each category contains distinct machine models, manufacturers, and protocols for use that are important to bear in mind in any attempt to compare these technologies.

Table 2 Efficacy in reducing bacterial colonies or site contamination

Of the devices under study, vaporized HP, or HP vapor, produces the best log reduction in colony-forming units (CFUs) achieving essentially complete eradication of experimentally placed bacteria in a test space [1416]. However, even with superior efficacy compared to other methods, evidence of residual contamination of site is present in the real-life setting [11, 17]. Of note, the study by Havill et al. demonstrates residual contamination of actual patient rooms even when the authors found complete eradication of experimentally placed C. difficile spores, calling into question whether experimentally inoculated surfaces are comparable to the results required in real contaminated patient rooms [17].

Aersolized HP can produce >5 log reductions, though a wide range (1 to >5) has been reported depending on the organism of interest and the experimental design [9, 18]. There is evidence of unequal dispersion of the aerosols through a space, such as dramatic variations of log reductions even in the same room [9] and increased time requirements to permeate certain spaces [18]. In addition, Fu et al. found decreased levels of aerosolized HP during cycles compared with vaporized HP at <50 ppm vs >100 pm at peak levels [9]. The decreased levels of aerosolized HP along with the distribution variations may be responsible for the decreased efficacy when compared to vaporized HP [9].

UV devices produce 3–5 log reductions depending on the type of organism and the experimental set up [1923]. Some studies of UVC devices use clinically present bioburden as opposed to experimentally placed bacteria to measure log reductions with device usage. Such a design produces notably lower log reductions than those seen with experimentally placed bacteria, because the starting concentrations are vastly different. For example, UVC produced 1.1–1.7 log reductions in clinically contaminated rooms where starting CFUs were 3.2–4.5 log [24]. Position of device in relation to the room and equipment is of great importance, as one study found that only 2.2 log reductions overall, and 53 % of sites still contaminated after a cycle due largely to the failure of the UVC device to penetrate into the adjoining bathroom [17]. The pulsed xenon UV (PX-UV) device attempts to overcome this issue by placing the machine at 3 different positions for 5 min at each site. Yet, Nerandzic et al. still found killing efficacy to be so distance dependent that they had to move mobile furniture and equipment into positions close to the PX-UV device to optimize performance [25]. PX-UV has the shortest time requirements of any of the touchless devices studied to date, yet also the lowest efficacy, with 0.5–1.85 log reductions found in one study [25]. The majority of studies of PX-UV have instead looked at reductions in patient room contamination, finding dramatic reductions when compared to baseline precleaned room contamination [26, 27].

Comparing Devices

Several studies have evaluated HP or UV devices in a head-to-head comparison. The first such study was done with vaporized HP (HPV) and aerosolized HP (aHP) tested against experimentally placed biological indicators at a concentration of 6 log. The HPV inactivated 100 % of the biological indicators while the aHP inactivated 10-79 % [28]. Fu et al. also evaluated HPV and aHP devices but used experimentally placed MRSA, C. difficile, and Acinetobacter; they found complete killing with the HPV device and incomplete, variable killing with the aHP device [9]. Interestingly, when HPV and an aerosolized HP device were applied in a clinical setting to perform terminal cleaning at patient discharge, no difference in efficacy was found by culturing sites within the room [11]. HPV has also been compared to a UVC device and found to be more efficacious in terms of log reductions in experimentally placed bacteria and also residual contaminated sites in patient rooms; UVC was not able to effectively penetrate some areas in the patient room [17]. Last, UVC has been compared to PX-UV and found to be superior in efficacy despite using a 10-min run time for both devices, which is half the usually recommended run time for UVC [25].

Effects of Organic Soiling

Discordant results have been reported when simulated soiling with organic material is used to mimic body fluids in the hospital environment. Many studies evaluating device efficacy included a soiling component; yet, the effect of soiling on killing efficacy remains unclear. Some studies find no difference in log reduction of bacteria when using an aerosolized HP device [18], and others find decreased killing depending on organism type with both vaporized HP and aerosolized HP devices [9]. One group reported disparate results even when using the same UVC devices, finding that a heavier soiling did decrease killing, while a more moderate soiling did not make a difference [22, 23]. Similarly, Zhang et al. found that heavy experimental soiling reduced efficacy of UVC devices against C. difficile, as well as heavy nonexperimental soiling though to a lesser extent. They further demonstrated that routine soiling of hospital rooms did not affect UVC cleaning and argue that precleaning of rooms is likely unnecessary when using these devices [29].

Clinical Efficacy and Infection Prevention

Although touchless technologies do not result in complete eradication of microbes from the patient environment, they further reduce residual contamination following standard room disinfection. Additionally, several published reports now support the clinical efficacy of touchless technologies (Table 3). Haas et al. reported their experience with a PX-UV device while obtaining a usage rate of 76 % of opportunities for terminal discharge cleaning of contact precaution rooms. They found a decrease of incident multidrug-resistant acquisitions and infections from 2.67 cases per 1000 patients days to 2.14 cases per 1000 patient days, albeit using a retrospective, quasi-experimental design evaluating times before and after a hospital-wide roll-out of the device. They employed PX-UV not only in terminal discharges, but also end of day OR suite and dialysis unit cleaning, and any other room on staff request [30]. Another study of C. difficile rates before and after hospital-wide roll-out of PX-UV demonstrated 54 % reduction in rates, from a stable 0.92 per 1000 patient days in the 2 years previous, to 0.45 per 1000 patient days in the year after its introduction. The authors collected data on antibiotic usage and other infection prevention practices to evaluate for possible confounding. They also noted a nonsignificant decrease in colectomy and death rates [31]. Passaretti et al. prospectively observed three cohorts before and after roll-out of vaporized HP in their institution. Two of the three cohorts did not use vaporized HP and thus allowed some control of confounding across different time periods. The authors succeeded in using vaporized HP in 74 % of opportunities in their “multidrug-resistant vaporized HP” arm and found a 64 % decrease in acquisitions of multidrug-resistant organisms by the next room occupants, largely driven by vancomycin-resistant Enterococcus (VRE). All other studied organisms revealed a trend toward reduction that was nonsignificant due to the low overall rate of patient acquisitions [32]. Another study evaluating vaporized HP in a quasi-experimental design found decreased C. difficile rates from 0.88 to 0.55 per 1000 patient days, though this study was limited by vaporized HP use in only 54 % of the discharges in the HP arm; all double occupancy rooms were cleaned with bleach four times instead of vaporized HP. The efficacy of repeated bleach cleanings could not be separated out from the vaporized HP in the outcome data; however, the authors argued that vaporized HP is much more tolerable to staff than four rounds of bleach cleaning [33]. While Mitchell et al. also found decreased MRSA acquisitions over time in their quasi-experimental study of vaporized HP, this was seriously confounded by lower rates of screening for MRSA in the period before roll-out. In addition, their HP data period included a combination of topical HP and vaporized HP usage for terminal cleaning, depending on single or double occupancies. Data for vaporized HP alone was not reported [34]. Last, while the study by Barbut has been cited to decrease clinical rates of MRSA and Acinetobacter, from 7.22 to 0.77 cases per 1000 patient days and 6.92 to 0.77, respectively, their addition of vaporized HP was one part of an infection prevention bundle implemented in response to an outbreak of MRSA in a burn unit, and is better categorized as an example of efficacy in outbreak settings [35].

Table 3 Efficacy in reducing health care associated acquisitions or infections

Control of Outbreaks

Experience using touchless technologies in outbreak settings is limited to aerosolized HP and vaporized HP. Organism type may be important in outcomes. While previous studies reported successes in terminating outbreaks due to MRSA [35, 36], Serratia [37], and C. difficile [38, 39], outbreaks due to Acinetobacter are often problematic despite the employment of touchless HP [4042]. Success with control of a C. difficile outbreak was reported by Best et al., when they decontaminated an entire closed stroke rehab unit with aerosolized HP, halting an outbreak with a peak prevalence of 10.8 %. Unfortunately, the authors noted that by 20-week postdecontamination, 3.5 % of room sites were again C. difficile positive. Of note, the study used aerosolized HP as a one-time intervention on the entire unit, and it was never integrated into routine terminal cleaning, where perhaps it may have helped suppress rates over a longer time period [38]. In contrast, Chmielarczyk et al. used vaporized HP on a closed unit to stop an outbreak of Acinetobacter that had affected 20 patients, only to have a second Acinetobacter outbreak occur 8 months later. An environmental reservoir was never found on extensive surveillance swabs collected by the investigators [40]. Landelle et al. reported an 18-month outbreak of Acinetobacter in multiple ICUs in which they used aerosolized HP for cleaning after terminal discharges without success, then vaporized HP on an entire closed unit only to have Acinetobacter recurrence upon reopening, then aerosolized HP again on two additional closed units. They reported that HP methods were unsuccessful, and only by cohorting patients with intensive infection control measures was the outbreak halted [41]. Last, another Acinetobacter outbreak offers clues as to why touchless methods may fail to eliminate certain environmental reservoirs. Alfandari et al. found Acinetobacter contaminating Velcro of blood pressure cuffs in their ICU, which suffered repeated cases of Acinetobacter infections despite use of aerosolized HP as one of many unsuccessful interventions to eradicate the bacteria from the environment. Only replacement of the cuffs ended the outbreak [42]. Aersolized HP is unlikely to penetrate a mesh at levels sufficient to eradicate Acinetobacter, which may be one major limitation of such technologies. Yet, even Acinectobacter outbreaks have been halted by vaporized HP in some instances [35, 43] (Table 4).

Table 4 Efficacy in outbreaks

Other Applications

Recognition that the patient room is an open system allowing for the constant movement of objects in and out has prompted the use of UV and HP technologies to interrupt other presumed routes of transmission. UVC had previously been used for successful decontamination of portable medical equipment [44]. More recently, another group investigated the effectiveness in vaporized HP decontamination of unused medical supplies in patient rooms. They were able to completely eradicate a baseline contamination rate of 7–9 % of supplies. Of note, they took each item out of the cart and placed it on a metal rack to maximize exposure to the vaporized HP, a step not typically performed at terminal discharge [45]. A portable pulsed UV light device being developed in Japan was used to decontaminate commonly touched surfaces outside of the patient room. They found the portable UV device superior to ethanol wipes in time (43 vs 22 min) and efficacy on complex surfaces such as phones, paper, and keyboards [46].


Safety concerns when using aerosolized HP devices were raised in some studies. The presence of residual HP in the room at the end of the cycle has been noted and resulted in complaints of irritation and odor [11]. Leakage of HP into adjacent areas has also been reported when the room was not taped and sealed during the cycle [9]. However, the other studies reviewed here make no mention of leakage or residual when rooms are taped and sufficiently aerated after the cycle.

Damage to surfaces or electronics is another concern often raised regarding touchless cleaning technologies. Few such incidents have been reported, though one study did note an “incompatibility” of wall paint in one of the units with vaporized HP employed in the study; this paint had to be replaced [32]. No studies in this review mention damage to electronics or medical equipment. One group specifically studied the maintenance records before and after the initiation of vaporized HP in their institution and did not find an increase in service calls over this time, but rather an unexplained decrease [47].


The issue of cost-effectiveness is often raised in discussions of UV and HP devices for environmental disinfection and decontamination of the health care system. One study attempting to calculate cost-effectiveness of vaporized HP compared to various manual cleaning methods found that the increased cost was not justified by the slight increase in efficacy by log reductions in experimentally placed bacteria [48]. The real test of cost-effectiveness will likely depend on whether or not these methods will be conclusively shown to decrease hospital-acquired infections. When the cost estimates for surgical site infections, ventilator-associated pneumonias, and catheter-associated bloodstream infections reach $20,000 per event [49] and hospitals are strongly incentivized to decrease rates, touchless technologies may be poised for cost-effectiveness if used judiciously.

Limitations of Current Data on Touchless Technologies for Hospital Disinfection

Of the studies reviewed, the vast majority are either prospective observational studies using simulated conditions, outbreak reports, or quasi-experimental designs. Of the few prospective studies performed under actual patient discharge conditions in the hospital, the sample sizes were generally small, and methods varied from study to study. Indeed, the only prospective controlled study related to clinical efficacy was Passaretti et al. [32]. Of note, another cluster randomized, prospective trial of the ability of UVC to impact patient acquisition of nosocomial pathogens is underway at 9 centers in the USA ( # NCT01579370).

There is also reason for concern for commercial bias within the literature, as many studies use the device on loan from the company, while other studies are sponsored by the company. Several papers even include authors who are employed by the company under study.


While some in vitro studies demonstrated complete killing of experimentally placed bacterial samples, no studies from actual patient rooms after discharge were able to document complete killing of all organisms contaminating the inanimate environment. Much like the challenges faced by standard manual cleaning, the complex surfaces and devices in a hospital room continue to harbor potential reservoirs of pathogens that even touchless methods are unable to eliminate completely.

It is difficult to interpret efficacy studies of touchless devices when the minimal environmental bioburden capable of producing nosocomial transmission remains uncertain. The available evidence on clinical outcomes, albeit for the most part based on low-quality studies, suggests that even incomplete reductions in bacterial loads can reduce patient acquisitions [11, 3033]. Yet, the experience in outbreak settings illustrate that it does not require a large burden of contamination to threaten the lives of multiple patients, but rather a single protected nidus of infection that is sheltered from decontamination interventions, such as the Velcro cuffs in the experience of Alfandari et al. [42]. The difficulty in locating such reservoirs adds further challenges to cleaning efforts [40]. Hence, even the most enhanced cleaning methods are subject to limitations that may fail to protect patients from environmentally transmitted hospital acquired infections.

The current data on UV and HP disinfection methods suggests that these technologies reduce residual room contamination, can be implemented into busy acute care institutions, and can be used safely within the protocols of specific devices. Convincing evidence of HAI reduction through UV and HP disinfection is lacking. With a steady ongoing refinement of these technologies, and increased experience in the health care setting, the evidence base can be anticipated to strengthen in the future. Thus, touchless cleaning technologies may provide an incremental benefit to standard infection prevention practices by further reducing the bioburden of the inanimate environment and potentially limiting the cross-transmission of pathogens via hospital surfaces.


  1. 1.

    Carling PC, Von Beheren S, Kim P, Woods C, Healthcare Environmental Hygiene Study Group. Intensive care unit environmental cleaning: an evaluation in sixteen hospitals using a novel assessment tool. J Hosp Infect. 2008;68:39–44.

    CAS  Article  PubMed  Google Scholar 

  2. 2.

    Huang SS, Datta R, Platt R. Risk of acquiring antibiotic-resistant bacteria from prior room occupants. Arch Intern Med. 2006;166(18):1945–51.

    Article  PubMed  Google Scholar 

  3. 3.

    Shaughnessy MK, Micielli RL, DePestel DD, Arndt J, Strachan CL, Welch KB, et al. Evaluation of hospital room assignment and acquisition of clostridium difficile infection. Infect Control Hosp Epidemiol. 2011;32(3):201–6.

    Article  PubMed  Google Scholar 

  4. 4.

    Nseir S, Blazejewski C, Lubret R, Wallet F, Courcol R, Durocher A. Risk of acquiring multidrug-resistant gram-negative bacilli from prior room occupants in the intensive care unit. Clin Microbiol Infect. 2011;17:1201–8.

    CAS  Article  PubMed  Google Scholar 

  5. 5.

    Humphreys H. Self-disinfecting and microbiocide-impregnated surfaces and fabrics: what potential in interrupting the spread of healthcare-associated infection? Clin Infect Dis. 2014;58(6):848–53.

    Article  PubMed  Google Scholar 

  6. 6.

    Davies A, Pottage T, Bennett A, Walker J. Gaseous and air decontamination technologies for clostridium difficile in the healthcare environment. J Hosp Infect. 2011;77:199–203.

    CAS  Article  PubMed  Google Scholar 

  7. 7.

    Rutala WA, Weber DJ. Disinfectants used for environmental disinfection and new room decontamination technology. Am J Infect Control. 2013;41:S36–41.

    Article  PubMed  Google Scholar 

  8. 8.

    Otter JA, Yezli S, Perl TM, Barbut F, French GL. The role of ‘no-touch’ automated room disinfection systems in infection prevention and control. J Hosp Infect. 2013;83:1–13.

    CAS  Article  PubMed  Google Scholar 

  9. 9.

    Fu TY, Gent P, Kumar V. Efficacy, efficiency and safety aspects of hydrogen peroxide vapour and aerosolized hydrogen peroxide room disinfection systems. J Hosp Infect. 2012;80:199–205.

    CAS  Article  PubMed  Google Scholar 

  10. 10.

    Chemical Sampling Information. OSHA. Accessed 10 April 2015.

  11. 11.

    Blazejewski C, Wallet F, Rouze A, et al. Efficiency of hydrogen peroxide in improving disinfection of ICU rooms. Crit Care. 2015;19:30.

    PubMed Central  Article  PubMed  Google Scholar 

  12. 12.

    Falagas ME, Thomaidis PC, Kotsantis IK, Sgouros K, Samonis G, Karageorgopoulos DE. Airborne hydrogen peroxide for disinfection of the hospital environment and infection control: a systematic review. J Hosp Infect. 2011;78:171–7.

    CAS  Article  PubMed  Google Scholar 

  13. 13.

    Canadian Agency of Drugs and Technologies in Health. Non-manual techniques for room disinfection in health care facilities: a review. 2014. Accessed 15 April 2015.

  14. 14.

    Barbut F, Yezli S, Otter JA. Activity in vitro of hydrogen peroxide vapour against clostridium difficile spores. J Hosp Infect. 2012;80:85–7.

    CAS  Article  PubMed  Google Scholar 

  15. 15.

    Galvin S, Boyle M, Russell RJ, et al. Evaluation of vaporized hydrogen peroxide, citrox and pH neutral ecasol for decontamination of an enclosed area: a pilot study. J Hosp Infect. 2012;80:67–70.

    CAS  Article  PubMed  Google Scholar 

  16. 16.

    Lemmen S, Scheithauer S, Hafner H, Yezli S, Mohr M, Otter JA. Evaluation of hydrogen peroxide vapor for the inactivation of nosocomial pathogens on porous and nonporous surfaces. Am J Infect Control. 2015;43:82–5.

    CAS  Article  PubMed  Google Scholar 

  17. 17.

    Havill NL, Moore BA, Boyce JM. Comparison of the microbiological efficacy of hydrogen peroxide vapor and ultraviolet light processes for room decontamination. Infect Control Hosp Epidemiol. 2012;33:507–12.

    Article  PubMed  Google Scholar 

  18. 18.

    Steindl G, Fiedler A, Huhulescu S, Wewalka G, Allerberger F. Effect of airborne hydrogen peroxide on spores of Clostridium difficile. Wien Klin Wochenschr. 2014.

  19. 19.

    Rutala WA, Gergen MF, Tande BM, Weber DJ. Rapid hospital room decontamination using ultraviolet (UV) light with a nanostructured UV-reflective wall coating. Infect Control Hosp Epidemiol. 2013;34:527–9.

    Article  PubMed  Google Scholar 

  20. 20.

    Rutala WA, Gergen MF, Tande BM, Weber DJ. Room decontamination using an ultraviolet-C device with short ultraviolet exposure time. Infect Control Hosp Epidemiol. 2014;35:1070–2.

    Article  PubMed  Google Scholar 

  21. 21.

    Rutala WA, Weber DJ, Gergen MF, Tande BM, Sickbert-Bennett EE. Does coating all room surfaces with an ultraviolet C light-nanoreflective coating improve decontamination compared with coating only the walls? Infect Control Hosp Epidemiol. 2014;35:323–5.

    Article  PubMed  Google Scholar 

  22. 22.

    Nerandzic MM, Cadnum JL, Pultz MJ, Donskey CJ. Evaluation of an automated ultraviolet radiation device for decontamination of clostridium difficile and other healthcare-associated pathogens in hospital rooms. BMC Infect Dis. 2010;10:197–2334. 10-197.

    PubMed Central  Article  PubMed  Google Scholar 

  23. 23.

    Nerandzic MM, Fisher CW, Donskey CJ. Sorting through the wealth of options: comparative evaluation of two ultraviolet disinfection systems. PLoS ONE. 2014;9:e107444.

    PubMed Central  Article  PubMed  Google Scholar 

  24. 24.

    Anderson DJ, Gergen MF, Smathers E, et al. Decontamination of targeted pathogens from patient rooms using an automated ultraviolet-C-emitting device. Infect Control Hosp Epidemiol. 2013;34:466–71.

    PubMed Central  Article  PubMed  Google Scholar 

  25. 25.

    Nerandzic MM, Thota P, Sankar CT, et al. Evaluation of a pulsed xenon ultraviolet disinfection system for reduction of healthcare-associated pathogens in hospital rooms. Infect Control Hosp Epidemiol. 2015;36:192–7.

    Article  PubMed  Google Scholar 

  26. 26.

    Ghantoji SS, Stibich M, Stachowiak J, et al. Non-inferiority of pulsed xenon UV light versus bleach for reducing environmental clostridium difficile contamination on high-touch surfaces in clostridium difficile infection isolation rooms. J Med Microbiol. 2015;64:191–4.

    Article  PubMed  Google Scholar 

  27. 27.

    Jinadatha C, Quezada R, Huber TW, Williams JB, Zeber JE, Copeland LA. Evaluation of a pulsed-xenon ultraviolet room disinfection device for impact on contamination levels of methicillin-resistant staphylococcus aureus. BMC Infect Dis. 2014;14:187–2334. 14-187.

    PubMed Central  Article  PubMed  Google Scholar 

  28. 28.

    Holmdahl T, Lanbeck P, Wullt M, Walder MH. A head-to-head comparison of hydrogen peroxide vapor and aersol room decontamination systems. Infect Control Hosp Epidemiol. 2011;32(9):831–6.

    CAS  Article  PubMed  Google Scholar 

  29. 29.

    Zhang A, Nerandzic MM, Kundrapu S, Donskey CJ. Does organic material on hospital surfaces reduce the effectiveness of hypochlorite and UV radiation for disinfection of Clostridium difficile? Infect Control Hosp Epidemiol. 2013;34:1106–8.

    Article  PubMed  Google Scholar 

  30. 30.

    Haas JP, Menz J, Dusza S, Montecalvo MA. Implementation and impact of ultraviolet environmental disinfection in an acute care setting. Am J Infect Control. 2014;42(6):586–90.

    Article  PubMed  Google Scholar 

  31. 31.

    Levin J, Riley LS, Parrish C, English D, Ahn S. The effect of portable pulsed xenon ultraviolet light after terminal cleaning on hospital-associated Clostridium difficile infection in a community hospital. Am J Infect Control. 2013;41:746–8.

    Article  PubMed  Google Scholar 

  32. 32.

    Passaretti CL, Otter JA, Reich NG, et al. An evaluation of environmental decontamination with hydrogen peroxide vapor for reducing the risk of patient acquisition of multidrug-resistant organisms. Clin Infect Dis. 2013;56:27–35.

    CAS  Article  PubMed  Google Scholar 

  33. 33.

    Manian FA, Griesnauer S, Bryant A. Implementation of hospital-wide enhanced terminal cleaning of targeted patient rooms and its impact on endemic clostridium difficile infection rates. Am J Infect Control. 2013;41(6):537–41.

    Article  PubMed  Google Scholar 

  34. 34.

    Mitchell BG, Digney W, Locket P, Dancer SJ. Controlling methicillin-resistant staphylococcus aureus (MRSA) in a hospital and the role of hydrogen peroxide decontamination: an interrupted time series analysis. BMJ Open. 2014;4:e004522. 2013-004522.

    PubMed Central  Article  PubMed  Google Scholar 

  35. 35.

    Barbut F, Yezli S, Mimoun M, Pham J, Chaouat M, Otter JA. Reducing the spread of acinetobacter baumannii and methicillin-resistant staphylococcus aureus on a burns unit through the intervention of an infection control bundle. Burns. 2013;39:395–403.

    Article  PubMed  Google Scholar 

  36. 36.

    Dryden M, Parnaby R, Dailly S, et al. Hydrogen peroxide vapour decontamination in the control of a polyclonal meticillin-resistant Staphylococcus aureus outbreak on a surgical ward. J Hosp Infect. 2008;68:190–2.

    CAS  Article  PubMed  Google Scholar 

  37. 37.

    Bates CJ, Pearse R. Use of hydrogen peroxide vapour for environmental control during a Serratia outbreak in a neonatal intensive care unit. J Hosp Infect. 2005;61(4):364–6.

    CAS  Article  PubMed  Google Scholar 

  38. 38.

    Best EL, Parnell P, Thirkell G, et al. Effectiveness of deep cleaning followed by hydrogen peroxide decontamination during high Clostridium difficile infection incidence. J Hosp Infect. 2014;87:25–33.

    CAS  Article  PubMed  Google Scholar 

  39. 39.

    Boyce JM, Havill NL, Otter JA, et al. Impact of hydrogen peroxide vapor room decontamination on clostridium difficile environmental contamination and transmission in a healthcare setting. Infect Control Hosp Epidemiol. 2008;29(8):723–9.

    Article  PubMed  Google Scholar 

  40. 40.

    Chmielarczyk A, Higgins PG, Wojkowska-Mach J, et al. Control of an outbreak of acinetobacter baumannii infections using vaporized hydrogen peroxide. J Hosp Infect. 2012;81:239–45.

    CAS  Article  PubMed  Google Scholar 

  41. 41.

    Landelle C, Legrand P, Lesprit P, et al. Protracted outbreak of multidrug-resistant acinetobacter baumannii after intercontinental transfer of colonized patients. Infect Control Hosp Epidemiol. 2013;34:119–24.

    Article  PubMed  Google Scholar 

  42. 42.

    Alfandari S, Gois J, Delannoy PY, et al. Management and control of a carbapenem-resistant acinetobacter baumannii outbreak in an intensive care unit. Med Mal Infect. 2014;44:229–31.

    CAS  Article  PubMed  Google Scholar 

  43. 43.

    Ray A, Perez F, Beltramini AM, et al. Use of vaporized hydrogen peroxide decontamination during an outbreak of multidrug-resistant acinetobacter baumannii infection at a long-term acute care hospital. Infect Control Hosp Epidemiol. 2010;31(12):1236–41.

    PubMed Central  Article  PubMed  Google Scholar 

  44. 44.

    Andersen BM, Rasch M, Hochlin K, Jensen FH, Wismar P, Fredriksen JE. Decontamination of rooms, medical equipment and ambulances using an aerosol of hydrogen peroxide disinfectant. J Hosp Infect. 2006;62:149–55.

    CAS  Article  PubMed  Google Scholar 

  45. 45.

    Otter JA, Nowakowski E, Salkeld JA, et al. Saving costs through the decontamination of the packaging of unused medical supplies using hydrogen peroxide vapor. Infect Control Hosp Epidemiol. 2013;34:472–8.

    Article  PubMed  Google Scholar 

  46. 46.

    Umezawa K, Asai S, Inokuchi S, Miyachi H. A comparative study of the bactericidal activity and daily disinfection housekeeping surfaces by a new portable pulsed UV radiation device. Curr Microbiol. 2012;64:581–7.

    CAS  Article  PubMed  Google Scholar 

  47. 47.

    Boyce JM, Havill NL, Cianci V, Flanagan G. Compatibility of hydrogen peroxide vapor room decontamination with physiological monitors. Infect Control Hosp Epidemiol. 2014;35:92–3.

    Article  PubMed  Google Scholar 

  48. 48.

    Doan L, Forrest H, Fakis A, Craig J, Claxton L, Khare M. Clinical and cost effectiveness of eight disinfection methods for terminal disinfection of hospital isolation rooms contaminated with clostridium difficile 027. J Hosp Infect. 2012;82:114–21.

    CAS  Article  PubMed  Google Scholar 

  49. 49.

    Scott RD. The direct medical costs of healthcare-associated infections in U.S. hospitals and the benefits of prevention. Division of Healthcare Quality Promotion, CDC. Accessed 15 April 2015.

Download references

Compliance with Ethics Guidelines

Conflict of Interest

Michelle Doll and Gonzalo Bearman have no conflicts of interest. Deverick Anderson reports royalties from Up To Date, Online, and grants from the CDC and NIH/NIAID. Daniel Morgan reports personal fees from Welch Allyn, grants from VA HSRD, travel expenses paid by IDSA, ASM, SHEA, and personal fees from 3 M.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by the author.

Author information



Corresponding author

Correspondence to Michelle Doll.

Additional information

This article is part of the Topical Collection on Healthcare Associated Infections

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Doll, M., Morgan, D.J., Anderson, D. et al. Touchless Technologies for Decontamination in the Hospital: a Review of Hydrogen Peroxide and UV Devices. Curr Infect Dis Rep 17, 44 (2015).

Download citation


  • Decontamination
  • Disinfection
  • Cleaning
  • Hydrogen peroxide
  • UV light
  • Ultraviolet
  • Touchless
  • Hospital
  • Health care
  • Infection prevention