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Eliminating Infections in the ICU: CLABSI


Central line-associated bloodstream infections (CLABSI) are one of the leading causes of death in the USA and around the world. As a preventable healthcare-associated infection, they are associated with significant morbidity and excess costs to the healthcare system. Effective and long-term CLABSI prevention requires a multifaceted approach, involving evidence-based best practices coupled with effective implementation strategies. Currently recommended practices are supported by evidence and are simple, such as appropriate hand hygiene, use of full barrier precautions, avoidance of femoral lines, skin antisepsis, and removal of unnecessary lines. The most successful and sustained improvements in CLABSI rates further utilize an adaptive component to align provider behaviors with consistent and reliable use of evidence-based practices. Great success has been achieved in reducing CLABSI rates in the USA and elsewhere over the past decade, but more is needed. This article aims to review the initiatives undertaken to reduce CLABSI and summarizes the sentinel and recent literature regarding CLABSI and its prevention.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Peter Pronovost, Asad Latif, and Muhammad Sohail Halim have no relevant disclosures to report.

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This article does not contain any studies with human or animal subjects performed by the author.

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Correspondence to Asad Latif.

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This article is part of the Topical Collection on Sepsis and ICU

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Latif, A., Halim, M.S. & Pronovost, P.J. Eliminating Infections in the ICU: CLABSI. Curr Infect Dis Rep 17, 35 (2015).

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  • Central line-associated bloodstream infection
  • Healthcare-acquired infections
  • Quality improvement
  • Patient safety
  • Critical care
  • Best practices