The Swiss Transplant Cohort Study: Lessons from the First 6 Years

Abstract

Prospective cohort studies significantly contribute to answering specific research questions in a defined population. Since 2008, the Swiss Transplant Cohort Study (STCS) systematically enrolled >95 % of all transplant recipients in Switzerland, collecting predefined data at determined time points. Designed as an open cohort, the STCS has included >3900 patients to date, with a median follow-up of 2.96 years (IQR 1.44–4.73). This review highlights some relevant findings in the field of transplant-associated infections gained by the STCS so far. Three key general aspects have crystallized: (i) Well-run cohort studies are a powerful tool to conduct genetic studies, which are crucially dependent on a meticulously described phenotype. (ii) Long-term real-life observations are adding a distinct layer of information that cannot be obtained during randomized studies. (iii) The systemic collection of data, close interdisciplinary collaboration, and continuous analysis of some key outcome data such as infectious diseases endpoints can improve patient care.

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Acknowledgments

The members of the Transplant Infectious Diseases working group of the Swiss Transplant Cohort Study sincerely acknowledge all persons involved in the implementation and for their continuing contributions to the Swiss Transplant Cohort Study. The Swiss Transplant Cohort Study is supported by the Swiss National Science Foundation, the Swiss University Hospitals (G15), and transplant centers.

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Conflict of Interest

Alexia Cusini, Katia Boggian, Nicolas Mueller, David Nadal, Maja Weisser, Nina Khanna, Pascal Meylan, Oriol Manuel, Adrian Egli, Matthias Hoffmann, Hans H. Hirsch, Christian Garzoni, Christian van Delden, and Christoph Berger have no relevant disclosures to report. Pierre-Yves Bochud received a grant from Mérieux and lecture payment from MSD, Ademtech, and Janssen and travel accommodations/meeting expenses from MSD.

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This article does not contain any studies with human or animal subjects performed by the author.

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Correspondence to Nicolas J. Mueller.

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This article is part of the Topical Collection on Transplant and Oncology

The members of the Swiss Transplant Cohort Study are as follows: Rita Achermann, John-David Aubert, Philippe Baumann, Guido Beldi, Christian Benden, Christoph Berger, Isabelle Binet, Pierre-Yves Bochud, Elsa Boely (Head of local data management), Heiner Bucher, Leo Bühler, Thierry Carell, Emmanuelle Catana, Yves Chalandon, Sabina de Geest, Olivier de Rougemont, Michael Dickenmann, Michel Duchosal, Thomas Fehr, Sylvie Ferrari-Lacraz, Christian Garzoni, Yvan Gasche, Paola Gasche Soccal, Emiliano Giostra, Déla Golshayan, Daniel Good, Karine Hadaya, Christoph Hess, Sven Hillinger, Hans H. Hirsch, Günther Hofbauer, Uyen Huynh-Do, Franz Immer, Richard Klaghofer, Michael Koller (Head of the data center), Thomas Kuntzen, Bettina Laesser, Roger Lehmann, Christian Lovis, Oriol Manuel, Hans-Peter Marti, Pierre Yves Martin, Pascal Meylan, (Head, Biological samples management group), Paul Mohacsi, Isabelle Morard, Philippe Morel, Ulrike Mueller, Nicolas J Mueller (Chairman Scientific Committee), Helen Mueller-McKenna, Thomas Müller, Beat Müllhaupt, David Nadal, Gayathri Nair, Manuel Pascual (Executive office), Jakob Passweg, Chantal Piot Ziegler, Juliane Rick, Eddy Roosnek, Anne Rosselet, Silvia Rothlin, Frank Ruschitzka, Urs Schanz, Stefan Schaub, Christian Seiler, Nasser Semmo, Susanne Stampf, Jürg Steiger (Head, Executive Office), Christian Toso, Dimitri Tsinalis, Christian Van Delden (Executive office), Jean-Pierre Venetz, Jean Villard, Madeleine Wick (STCS coordinator), Markus Wilhelm, and Patrick Yerly.

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Berger, C., Bochud, PY., Boggian, K. et al. The Swiss Transplant Cohort Study: Lessons from the First 6 Years. Curr Infect Dis Rep 17, 29 (2015). https://doi.org/10.1007/s11908-015-0486-5

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Keywords

  • Observational studies
  • Transplantation
  • Infectious diseases
  • Cohort studies
  • Genetic studies