Current Infectious Disease Reports

, Volume 15, Issue 6, pp 526–535 | Cite as

Organ Transplantation in HIV Patients: Current Status and New Directions

Transplant and Oncology (M Ison and N Theodoropoulos, Section Editors)

Abstract

Combination antiretroviral therapy has resulted in longer life expectancies in persons living with HIV; however, end organ disease and death from organ failure have become growing issues for this population. With effective therapies for viral suppression, HIV is no longer considered an absolute contraindication to organ transplantation. Over the past decade, studies of transplantation in patients with HIV have had encouraging results such that patients with organ failure are pursuing transplantation. This review focuses on the current status of organ transplantation for HIV-infected persons.

Keywords

Human immunodeficiency virus Acquired immunodeficiency syndrome Hepatitis C infection Hepatitis B infection Organ transplantation Kidney transplantation Liver transplantation Hematopoietic stem cell transplantation Heart transplantation Mechanical circulatory support Pancreas transplantation Lung transplantation 

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.
    Palella Jr FJ, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998;338:853–60.PubMedCrossRefGoogle Scholar
  2. 2.
    Bickel M, Marben W, Betz C, Khaykin P, Stephan C, Gute P, et al. End-stage renal disease and dialysis in HIV-positive patients: observations from a long-term cohort study with a follow-up of 22 years. HIV Med. 2013;14:127–35.PubMedCrossRefGoogle Scholar
  3. 3.
    Abbott KC, Trespalacios FC, Agodoa LY, Ahuja TS. HIVAN and medication use in chronic dialysis patients in the United States: analysis of the USRDS DMMS Wave 2 study. BMC Nephrol. 2003;4:5.PubMedCrossRefGoogle Scholar
  4. 4.
    Norman SP, Kommareddi M, Kaul DR. Update on kidney transplantation in HIV-infected recipients. AIDS Rev. 2012;14:195–207.PubMedGoogle Scholar
  5. 5.
    Trullas JC, Mocroft A, Cofan F, Tourret J, Moreno A, Bagnis CI, et al. Dialysis and renal transplantation in HIV-infected patients: a European survey. J Acquir Immune Defic Syndr. 2010;55:582–9.PubMedCrossRefGoogle Scholar
  6. 6.
    Kumar MS, Sierka DR, Damask AM, Fyfe B, McAlack RF, Heifets M, et al. Safety and success of kidney transplantation and concomitant immunosuppression in HIV-positive patients. Kidney Int. 2005;67:1622–9.PubMedCrossRefGoogle Scholar
  7. 7.
    Ryom L, Kirk O, Lundgren J, Reiss P, Pedersen C, De Wit S, et al. Advanced chronic kidney disease, end-stage renal disease and renal death among HIV-positive individuals in Europe. HIV Med. 2013;14:503–8.PubMedCrossRefGoogle Scholar
  8. 8.
    Atta MG, Fine DM, Kirk GD, Mehta SH, Moore RD, Lucas GM. Survival during renal replacement therapy among African Americans infected with HIV type 1 in urban Baltimore, Maryland. Clin Infect Dis. 2007;45:1625–32.PubMedCrossRefGoogle Scholar
  9. 9.
    Choi AI, Rodriguez RA, Bacchetti P, Volberding PA, Havlir D, Bertenthal D, et al. Low rates of antiretroviral therapy among HIV-infected patients with chronic kidney disease. Clin Infect Dis. 2007;45:1633–9.PubMedCrossRefGoogle Scholar
  10. 10.
    Trullas JC, Cofan F, Barril G, Martinez-Castelao A, Jofre R, Rivera M, et al. Outcome and prognostic factors in HIV-1-infected patients on dialysis in the cART era: a GESIDA/SEN cohort study. J Acquir Immune Defic Syndr. 2011;57:276–83.PubMedCrossRefGoogle Scholar
  11. 11.
    Ryom L, Mocroft A, Kirk O, Worm SW, Kamara DA, Reiss P, et al. Association between antiretroviral exposure and renal impairment among HIV-positive persons with normal baseline renal function: the D:A:D study. J Infect Dis. 2013;207:1359–69.PubMedCrossRefGoogle Scholar
  12. 12.
    Morlat P, Vivot A, Vandenhende MA, Dauchy FA, Asselineau J, Deti E, et al. Role of traditional risk factors and antiretroviral drugs in the incidence of chronic kidney disease, ANRS CO3 Aquitaine cohort, France, 2004-2012. PLoS One. 2013;8:e66223.PubMedCrossRefGoogle Scholar
  13. 13.
    Zaidan M, Lescure FX, Brocheriou I, Dettwiler S, Guiard-Schmid JB, Pacanowski J, et al. Tubulointerstitial nephropathies in HIV-infected patients over the past 15 years: a clinico-pathological study. Clin J Am Soc Nephrol. 2013;8:930–8.PubMedCrossRefGoogle Scholar
  14. 14.
    Abraham AG, Li X, Jacobson LP, Estrella MM, Evans RW, Witt MD, Phair J: Antiretroviral Therapy-Induced Changes in Plasma Lipids and the Risk of Kidney Dysfunction in HIV-Infected Men. AIDS Res Hum Retroviruses 2013;10:1346–52.Google Scholar
  15. 15.
    Lucas GM, Jing Y, Sulkowski M, Abraham AG, Estrella MM, Atta MG, Fine DM, Klein MB, Silverberg MJ, Gill MJ, et al.: Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals. J Infect Dis 2013;208:1240-9.Google Scholar
  16. 16.
    Mocroft A, Neuhaus J, Peters L, Ryom L, Bickel M, Grint D, et al. Hepatitis B and C co-infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults. PLoS One. 2012;7:e40245.PubMedCrossRefGoogle Scholar
  17. 17.
    Stock PG, Roland ME, Carlson L, Freise CE, Roberts JP, Hirose R, et al. Kidney and liver transplantation in human immunodeficiency virus-infected patients: a pilot safety and efficacy study. Transplantation. 2003;76:370–5.PubMedCrossRefGoogle Scholar
  18. 18.
    •• Stock PG, Barin B, Murphy B, Hanto D, Diego JM, Light J, et al. Outcomes of kidney transplantation in HIV-infected recipients. N Engl J Med. 2010;363:2004–14. The authors present the outcomes of 150 HIV+ kidney recipients in a U.S. multicenter trial.PubMedCrossRefGoogle Scholar
  19. 19.
    Touzot M, Pillebout E, Matignon M, Tricot L, Viard JP, Rondeau E, et al. Renal transplantation in HIV-infected patients: the Paris experience. Am J Transplant. 2010;10:2263–9.PubMedCrossRefGoogle Scholar
  20. 20.
    Malat GE, Ranganna KM, Sikalas N, Liu L, Jindal RM, Doyle A. High frequency of rejections in HIV-positive recipients of kidney transplantation: a single center prospective trial. Transplantation. 2012;94:1020–4.PubMedCrossRefGoogle Scholar
  21. 21.
    Mazuecos A, Fernandez A, Zarraga S, Andres A, Rodriguez-Benot A, Jimenez C, Gomez E, Paul J, Jimeno L, Fernandez C,et al.: High incidence of delayed graft function in HIV-infected kidney transplant recipients. Transpl Int 2013;26:893-902.Google Scholar
  22. 22.
    Mazuecos A, Fernandez A, Andres A, Gomez E, Zarraga S, Burgos D, et al. HIV infection and renal transplantation. Nephrol Dial Transplant. 2011;26:1401–7.PubMedCrossRefGoogle Scholar
  23. 23.
    Blumberg EA, Rogers CC, Practice ASTIDCo. Human immunodeficiency virus in solid organ transplantation. Am J Transplant. 2013;13 Suppl 4:169–78.PubMedCrossRefGoogle Scholar
  24. 24.
    Gomez V, Fernandez A, Galeano C, Oliva J, Diez V, Bueno C, et al. Renal transplantation in HIV-infected patients: experience at a tertiary hospital in Spain and review of the literature. Transplant Proc. 2013;45:1255–9.PubMedCrossRefGoogle Scholar
  25. 25.
    Muthukumar T, Afaneh C, Ding R, Tsapepas D, Lubetzky M, Jacobs S, et al. HIV-infected kidney graft recipients managed with an early corticosteroid withdrawal protocol: clinical outcomes and messenger RNA profiles. Transplantation. 2013;95:711–20.PubMedCrossRefGoogle Scholar
  26. 26.
    Yoon SC, Hurst FP, Jindal RM, George SA, Neff RT, Agodoa LY, et al. Trends in renal transplantation in patients with human immunodeficiency virus infection: an analysis of the United States renal data system. Transplantation. 2011;91:864–8.PubMedCrossRefGoogle Scholar
  27. 27.
    Vivanco M, Friedmann P, Xia Y, Klair T, Marfo K, de Boccardo G,Greenstein S, Chapochnick-Friedmann J, Kinkhabwala M, Ajaimy M, et al.: Campath induction in HCV and HCV/HIV-seropositive kidney transplant recipients. Transpl Int 2013;26:1016-26.Google Scholar
  28. 28.
    Tan HP, Kaczorowski DJ, Basu A, Khan A, McCauley J, Marcos A, et al. Living-related donor renal transplantation in HIV+ recipients using alemtuzumab preconditioning and steroid-free tacrolimus monotherapy: a single center preliminary experience. Transplantation. 2004;78:1683–8.PubMedCrossRefGoogle Scholar
  29. 29.
    Sawinski D, Wyatt CM, Casagrande L, Myoung P, Bijan I, Akalin E, et al. Factors associated with failure to list HIV-positive kidney transplant candidates. Am J Transplant. 2009;9:1467–71.PubMedCrossRefGoogle Scholar
  30. 30.
    Rodrigue JR, Paek MJ, Egbuna O, Waterman AD, Pavlakis M, Mandelbrot DA. Willingness to pursue live-donor kidney transplantation among waitlisted patients infected with human immunodeficiency virus (HIV): a preliminary investigation. Transplantation. 2013;95:787–90.PubMedCrossRefGoogle Scholar
  31. 31.
    Soriano V, Poveda E, Vispo E, Barreiro P. Hepatitis B in HIV-infected patients. Clin Liver Dis. 2013;17:489–501.PubMedCrossRefGoogle Scholar
  32. 32.
    Soriano V, Vispo E, Fernandez-Montero JV, Labarga P, Barreiro P. Update on HIV/HCV coinfection. Curr HIV/AIDS Rep. 2013;10:226–34.PubMedCrossRefGoogle Scholar
  33. 33.
    Ragni MV, Devera ME, Roland ME, Wong M, Stosor V, Sherman KE, et al. Liver transplant outcomes in HIV+ haemophilic men. Haemophilia. 2013;19:134–40.PubMedCrossRefGoogle Scholar
  34. 34.
    Weber R, Sabin CA, Friis-Moller N, Reiss P, El-Sadr WM, Kirk O, et al. Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study. Arch Intern Med. 2006;166:1632–41.PubMedCrossRefGoogle Scholar
  35. 35.
    Soriano V, Puoti M, Garcia-Gasco P, Rockstroh JK, Benhamou Y, Barreiro P, et al. Antiretroviral drugs and liver injury. AIDS. 2008;22:1–13.PubMedCrossRefGoogle Scholar
  36. 36.
    Palella Jr FJ, Baker RK, Moorman AC, Chmiel JS, Wood KC, Brooks JT, et al. Mortality in the highly active antiretroviral therapy era: changing causes of death and disease in the HIV outpatient study. J Acquir Immune Defic Syndr. 2006;43:27–34.PubMedCrossRefGoogle Scholar
  37. 37.
    Bica I, McGovern B, Dhar R, Stone D, McGowan K, Scheib R, et al. Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis. 2001;32:492–7.PubMedCrossRefGoogle Scholar
  38. 38.
    Weber R, Ruppik M, Rickenbach M, Spoerri A, Furrer H, Battegay M, et al. Decreasing mortality and changing patterns of causes of death in the Swiss HIV Cohort Study. HIV Med. 2013;14:195–207.PubMedCrossRefGoogle Scholar
  39. 39.
    Antiretroviral Therapy Cohort C. Causes of death in HIV-1-infected patients treated with antiretroviral therapy, 1996-2006: collaborative analysis of 13 HIV cohort studies. Clin Infect Dis. 2010;50:1387–96.CrossRefGoogle Scholar
  40. 40.
    Wada N, Jacobson LP, Cohen M, French A, Phair J, Munoz A. Cause-specific life expectancies after 35 years of age for human immunodeficiency syndrome-infected and human immunodeficiency syndrome-negative individuals followed simultaneously in long-term cohort studies, 1984-2008. Am J Epidemiol. 2013;177:116–25.PubMedCrossRefGoogle Scholar
  41. 41.
    Leone S, Gregis G, Quinzan G, Velenti D, Cologni G, Soavi L, et al. Causes of death and risk factors among HIV-infected persons in the HAART era: analysis of a large urban cohort. Infection. 2011;39:13–20.PubMedCrossRefGoogle Scholar
  42. 42.
    Moreno A, Cervera C, Fortun J, Blanes M, Montejo E, Abradelo M, et al. Epidemiology and outcome of infections in human immunodeficiency virus/hepatitis C virus-coinfected liver transplant recipients: a FIPSE/GESIDA prospective cohort study. Liver Transpl. 2012;18:70–81.PubMedCrossRefGoogle Scholar
  43. 43.
    Anadol E, Beckebaum S, Radecke K, Paul A, Zoufaly A, Bickel M, et al. Orthotopic liver transplantation in human-immunodeficiency-virus-positive patients in Germany. AIDS Res Treat. 2012;2012:197501.PubMedGoogle Scholar
  44. 44.
    Kemmer NM, Sherman KE. Liver transplantation trends in the HIV population. Dig Dis Sci. 2011;56:3393–8.PubMedCrossRefGoogle Scholar
  45. 45.
    Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, et al. HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes. Am J Transplant. 2008;8:355–65.PubMedCrossRefGoogle Scholar
  46. 46.
    Tateo M, Roque-Afonso AM, Antonini TM, Medja F, Lombes A, Jardel C, et al. Long-term follow-up of liver transplanted HIV/hepatitis B virus coinfected patients: perfect control of hepatitis B virus replication and absence of mitochondrial toxicity. AIDS. 2009;23:1069–76.PubMedCrossRefGoogle Scholar
  47. 47.
    Terrault NA, Carter JT, Carlson L, Roland ME, Stock PG. Outcome of patients with hepatitis B virus and human immunodeficiency virus infections referred for liver transplantation. Liver Transpl. 2006;12:801–7.PubMedCrossRefGoogle Scholar
  48. 48.
    Cooper C, Kanters S, Klein M, Chaudhury P, Marotta P, Wong P, et al. Liver transplant outcomes in HIV-infected patients: a systematic review and meta-analysis with synthetic cohort. AIDS. 2011;25:777–86.PubMedCrossRefGoogle Scholar
  49. 49.
    Mindikoglu AL, Regev A, Magder LS. Impact of human immunodeficiency virus on survival after liver transplantation: analysis of United Network for Organ Sharing database. Transplantation. 2008;85:359–68.PubMedCrossRefGoogle Scholar
  50. 50.
    Coffin CS, Stock PG, Dove LM, Berg CL, Nissen NN, Curry MP, et al. Virologic and clinical outcomes of hepatitis B virus infection in HIV-HBV coinfected transplant recipients. Am J Transplant. 2010;10:1268–75.PubMedCrossRefGoogle Scholar
  51. 51.
    de Vera ME, Dvorchik I, Tom K, Eghtesad B, Thai N, Shakil O, et al. Survival of liver transplant patients coinfected with HIV and HCV is adversely impacted by recurrent hepatitis C. Am J Transplant. 2006;6:2983–93.PubMedCrossRefGoogle Scholar
  52. 52.
    Duclos-Vallee JC, Feray C, Sebagh M, Teicher E, Roque-Afonso AM, Roche B, et al. Survival and recurrence of hepatitis C after liver transplantation in patients coinfected with human immunodeficiency virus and hepatitis C virus. Hepatology. 2008;47:407–17.PubMedCrossRefGoogle Scholar
  53. 53.
    Di Benedetto F, Tarantino G, De Ruvo N, Cautero N, Montalti R, Guerrini GP, et al. University of Modena experience in HIV-positive patients undergoing liver transplantation. Transplant Proc. 2011;43:1114–8.PubMedCrossRefGoogle Scholar
  54. 54.
    • Miro JM, Montejo M, Castells L, Rafecas A, Moreno S, Aguero F, et al. Outcome of HCV/HIV-coinfected liver transplant recipients: a prospective and multicenter cohort study. Am J Transplant. 2012;12:1866–76. The authors report the outcomes of 84 HIVHCV coinfected liver recipients, as compared with HCV monoinfected control group.PubMedCrossRefGoogle Scholar
  55. 55.
    • Terrault NA, Roland ME, Schiano T, Dove L, Wong MT, Poordad F, et al. Outcomes of liver transplant recipients with hepatitis C and human immunodeficiency virus coinfection. Liver Transpl. 2012;18:716–26. The authors demonstrate lower survival of 89 HIVHCV coinfected liver recipients, as compared with HCV-monoinfected patients.PubMedCrossRefGoogle Scholar
  56. 56.
    Chin-Hong P, Beatty G, Stock P. Perspectives on liver and kidney transplantation in the human immunodeficiency virus-infected patient. Infect Dis Clin North Am. 2013;27:459–71.PubMedCrossRefGoogle Scholar
  57. 57.
    Toso C, Berney T, Oberholzer J, Chave JP, Martin PY, Zeender E, et al. Kidney-pancreas transplantation in a long-term non-progressor HIV-infected recipient. Am J Transplant. 2003;3:631–3.PubMedCrossRefGoogle Scholar
  58. 58.
    Dalla Gasperina D, Tozzi M, Astuti N, Balsamo ML, Donati D, Rossi A, et al. Pulmonary tuberculosis in an HIV- and hepatitis C virus-coinfected kidney-pancreas transplant recipient: a case report. Transplant Proc. 2011;43:1206–9.PubMedCrossRefGoogle Scholar
  59. 59.
    Akhtar MZ, Patel N, Devaney A, Sinha S, Shankar S, Vaidya A, et al. Simultaneous pancreas kidney transplantation in the HIV-positive patient. Transplant Proc. 2011;43:3903–4.PubMedCrossRefGoogle Scholar
  60. 60.
    Grossi PA, Righi E, Gasperina DD, Donati D, Tozzi M, Mangini M, et al. Report of four simultaneous pancreas-kidney transplants in HIV-positive recipients with favorable outcomes. Am J Transplant. 2012;12:1039–45.PubMedCrossRefGoogle Scholar
  61. 61.
    Hayes K, Van Sickels N, Buell J, Killackey M, Zhang R, Slakey D, et al. Successful transplantation of HIV patients: the Louisiana experience. J La State Med Soc. 2012;164:191–3.PubMedGoogle Scholar
  62. 62.
    Miro JM, Ricart MJ, Trullas JC, Cofan F, Cervera C, Brunet M, et al. Simultaneous pancreas-kidney transplantation in HIV-infected patients: a case report and literature review. Transplant Proc. 2010;42:3887–91.PubMedCrossRefGoogle Scholar
  63. 63.
    Genzini T, Noujaim HM, Mota LT, Crescentini F, Antunes I, Di Jura VL, et al. Simultaneous pancreas-kidney transplantation in a human immunodeficiency virus-positive recipient: a case report. Transplant Proc. 2010;42:591–3.PubMedCrossRefGoogle Scholar
  64. 64.
    Jahangiri B, Haddad H. Cardiac transplantation in HIV-positive patients: are we there yet? J Heart Lung Transplant. 2007;26:103–7.PubMedCrossRefGoogle Scholar
  65. 65.
    Boccara F, Lang S, Meuleman C, Ederhy S, Mary-Krause M, Costagliola D, et al. HIV and coronary heart disease: time for a better understanding. J Am Coll Cardiol. 2013;61:511–23.PubMedCrossRefGoogle Scholar
  66. 66.
    Calabrese LH, Albrecht M, Young J, McCarthy P, Haug M, Jarcho J, et al. Successful cardiac transplantation in an HIV-1-infected patient with advanced disease. N Engl J Med. 2003;348:2323–8.PubMedCrossRefGoogle Scholar
  67. 67.
    Bisleri G, Morgan JA, Deng MC, Mancini DM, Oz MC. Should HIV-positive recipients undergo heart transplantation? J Thorac Cardiovasc Surg. 2003;126:1639–40.PubMedCrossRefGoogle Scholar
  68. 68.
    Morgan JA, Bisleri G, Mancini DM. Cardiac transplantation in an HIV-1-infected patient. N Engl J Med. 2003;349:1388–9. author reply 1388-1389.PubMedCrossRefGoogle Scholar
  69. 69.
    Uriel N, Jorde UP, Cotarlan V, Colombo PC, Farr M, Restaino SW, et al. Heart transplantation in human immunodeficiency virus-positive patients. J Heart Lung Transplant. 2009;28:667–9.PubMedCrossRefGoogle Scholar
  70. 70.
    Boignard A, Blanc M, Chavanon O. High-urgency priority heart transplantation in HIV-positive patients on life support: breaking barriers? J Heart Lung Transplant. 2011;30:968–9.PubMedGoogle Scholar
  71. 71.
    Durante-Mangoni E, Maiello C, Sbreglia C. A European first: successful heart transplant in a human immunodeficiency virus-positive recipient. J Heart Lung Transplant. 2011;30:845.PubMedCrossRefGoogle Scholar
  72. 72.
    Krishan K, Pinney S, Anyanwu AC. Successful left ventricular assist device bridge to transplantation in a patient with end-stage heart failure and human immunodeficiency virus. Artif Organs. 2012;36:759.PubMedCrossRefGoogle Scholar
  73. 73.
    Dizon SN, N; Han J, Yuzefpolskaya M, Restaino SW, Garan AR, Colombo PC, Takayama, H., Mancini, DM., Naka, Y., Jorde, UP, Uriel, N. et al.: [570] Cardiac allograft vasculopathy in HIV-infected patients. Presented at the ISHLT 33rd Annual Meeting & Scientific Sessions, Montreal, Canada - April 24-27, 2013. J Heart Lung Transplant 2013;32:S210.Google Scholar
  74. 74.
    Brucato A, Colombo T, Bonacina E, Orcese C, Vago L, Oliva F, et al. Fulminant myocarditis during HIV seroconversion: recovery with temporary left ventricular mechanical assistance. Ital Heart J. 2004;5:228–31.PubMedGoogle Scholar
  75. 75.
    Sims DB, Uriel N, Gonzalez-Costello J, Deng MC, Restaino SW, Farr MA, et al. Human immunodeficiency virus infection and left ventricular assist devices: a case series. J Heart Lung Transplant. 2011;30:1060–4.PubMedCrossRefGoogle Scholar
  76. 76.
    Mehmood S, Blais D, Martin S, Sai-Sudhakar C. Heartmate XVE destination therapy for end-stage heart failure in a patient with human immunodeficiency virus. Interact Cardiovasc Thorac Surg. 2009;9:909–10.PubMedCrossRefGoogle Scholar
  77. 77.
    Fieno DS, Czer LS, Schwarz ER, Simsir S. Left ventricular assist device placement in a patient with end-stage heart failure and human immunodeficiency virus. Interact Cardiovasc Thorac Surg. 2009;9:919–20.PubMedCrossRefGoogle Scholar
  78. 78.
    Uriel NC, PC, Yuzefpolskaya M, Restaino SW, Nahumi N, Han J, Thomas SS, Garan, AR.,Takayama HM, DM, Naka, Y, Jorde, UP [371] Advanced Heart Failure Therapy in HIV Positive Patients: Do These Patients Get Equal Treatment?. Presented at the ISHLT 33rd Annual Meeting & Scientific Sessions, Montreal, Canada - April 24-27, 2013. J Heart Lung Transplant 2013;32:S142-143.Google Scholar
  79. 79.
    Bertani A, Grossi P, Vitulo P, D'Ancona G, Arcadipane A, Nanni Costa A, et al. Successful lung transplantation in an HIV- and HBV-positive patient with cystic fibrosis. Am J Transplant. 2009;9:2190–6.PubMedCrossRefGoogle Scholar
  80. 80.
    Grossi PA. Update in HIV infection in organ transplantation. Curr Opin Organ Transplant. 2012;17:586–93.PubMedCrossRefGoogle Scholar
  81. 81.
    • van Maarseveen EM, Rogers CC, Trofe-Clark J, van Zuilen AD, Mudrikova T. Drug-drug interactions between antiretroviral and immunosuppressive agents in HIV-infected patients after solid organ transplantation: a review. AIDS Patient Care STDS. 2012;26:568–81. A comprehensive review of the complex drug interactions that occur between antiretroviral and immunosuppressive agents.PubMedCrossRefGoogle Scholar
  82. 82.
    Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, et al. Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. Am J Transplant. 2007;7:2816–20.PubMedCrossRefGoogle Scholar
  83. 83.
    Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, et al. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Transplantation. 2005;80:13–7.PubMedCrossRefGoogle Scholar
  84. 84.
    Cousins D, Topping K, Lee V, Sweeney J, Lawton M. Successful tacrolimus treatment following renal transplant in a HIV-infected patient with raltegravir previously treated with a protease inhibitor based regimen. Drug Metabol Drug Interact. 2011;26:139–41.PubMedCrossRefGoogle Scholar
  85. 85.
    Pulzer A, Seybold U, Schonermarck U, Stangl M, Habicht A, Bogner JR, et al. Calcineurin inhibitor dose-finding before kidney transplantation in HIV patients. Transpl Int. 2013;26:254–8.PubMedCrossRefGoogle Scholar
  86. 86.
    Bickel M, Anadol E, Vogel M, Hofmann WP, von Hentig N, Kuetscher J, et al. Daily dosing of tacrolimus in patients treated with HIV-1 therapy containing a ritonavir-boosted protease inhibitor or raltegravir. J Antimicrob Chemother. 2010;65:999–1004.PubMedCrossRefGoogle Scholar
  87. 87.
    Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. Available at http://aidsinfo.nih.gov/contentfiles/lvguidelines/AdultandAdolescentGL.pdf. Section accessed September 10, 2013.
  88. 88.
    Moreno A, Perez-Elias MJ, Casado JL, Fortun J, Barcena R, Quereda C, et al. Raltegravir-based highly active antiretroviral therapy has beneficial effects on the renal function of human immunodeficiency virus-infected patients after solid organ transplantation. Liver Transpl. 2010;16:530–2.PubMedGoogle Scholar
  89. 89.
    Tricot L, Teicher E, Peytavin G, Zucman D, Conti F, Calmus Y, et al. Safety and efficacy of raltegravir in HIV-infected transplant patients cotreated with immunosuppressive drugs. Am J Transplant. 2009;9:1946–52.PubMedCrossRefGoogle Scholar
  90. 90.
    Heidenhain C, Puhl G, Moench C, Lautem A, Neuhaus P. Chemokine receptor 5Delta32 mutation reduces the risk of acute rejection in liver transplantation. Ann Transplant. 2009;14:36–44.PubMedGoogle Scholar
  91. 91.
    Fischereder M, Luckow B, Hocher B, Wuthrich RP, Rothenpieler U, Schneeberger H, et al. CC chemokine receptor 5 and renal-transplant survival. Lancet. 2001;357:1758–61.PubMedCrossRefGoogle Scholar
  92. 92.
    Haim-Boukobza S, Balabanian K, Teicher E, Bourgeade M, Perlemuter G, Roque-Afonso AM, et al. Blockade of CCR5 to protect the liver graft in HIV/HCV co-infected patients. J Hepatol. 2013;59:613–5.PubMedCrossRefGoogle Scholar
  93. 93.
    Strieter RM, Belperio JA. Chemokine receptor polymorphism in transplantation immunology: no longer just important in AIDS. Lancet. 2001;357:1725–6.PubMedCrossRefGoogle Scholar
  94. 94.
    Gilliam BL, Riedel DJ, Redfield RR. Clinical use of CCR5 inhibitors in HIV and beyond. J Transl Med. 2011;9 Suppl 1:S9.PubMedCrossRefGoogle Scholar
  95. 95.
    Stallone G, Schena A, Infante B, Di Paolo S, Loverre A, Maggio G, et al. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med. 2005;352:1317–23.PubMedCrossRefGoogle Scholar
  96. 96.
    Heredia A, Latinovic O, Gallo RC, Melikyan G, Reitz M, Le N, et al. Reduction of CCR5 with low-dose rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1. Proc Natl Acad Sci U S A. 2008;105:20476–81.PubMedCrossRefGoogle Scholar
  97. 97.
    Heredia A, Amoroso A, Davis C, Le N, Reardon E, Dominique JK, et al. Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV beta-chemokines: an approach to suppress R5 strains of HIV-1. Proc Natl Acad Sci U S A. 2003;100:10411–6.PubMedCrossRefGoogle Scholar
  98. 98.
    Di Benedetto F, Di Sandro S, De Ruvo N, Montalti R, Ballarin R, Guerrini GP, et al. First report on a series of HIV patients undergoing rapamycin monotherapy after liver transplantation. Transplantation. 2010;89:733–8.PubMedCrossRefGoogle Scholar
  99. 99.
    Muller E, Kahn D, Mendelson M. Renal transplantation between HIV-positive donors and recipients. N Engl J Med. 2010;362:2336–7.PubMedCrossRefGoogle Scholar
  100. 100.
    •• Boyarsky BJ, Hall EC, Singer AL, Montgomery RA, Gebo KA, Segev DL. Estimating the potential pool of HIV-infected deceased organ donors in the United States. Am J Transplant. 2011;11:1209–17. The authors report the results of a study that estimates the potential pool of HIV+ organ donors. PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Divisions of Infectious Diseases and Organ Transplantation and Comprehensive Transplant CenterNorthwestern University Feinberg School of MedicineChicagoUSA

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