Gynecologic Clostridial Toxic Shock in Women of Reproductive Age

Urinary Tract Infections (Jack D. Sobel, Section Editor)

DOI: 10.1007/s11908-011-0207-7

Cite this article as:
Zane, S. & Guarner, J. Curr Infect Dis Rep (2011) 13: 561. doi:10.1007/s11908-011-0207-7


Clostridial toxic shock, caused by Clostridium sordellii or Clostridium perfringens, is a rare and largely fatal syndrome among reproductive-aged women with genital tract infection, and may occur following various pregnancy outcomes or without pregnancy. Clinicians should be aware of common clinical features of this very rapidly-progressing syndrome including abdominal pain, tachycardia, hypotension, third-space fluid accumulations, hemoconcentration, and marked leukemoid response, often with lack of fever. In this review, we summarize known cases through mid-2011 and information on clinical presentation, diagnosis, treatment, and results of recent investigations regarding pathogenesis, including germination, toxins, and host response that may have important implications for development of preventive or therapeutic interventions.


Clostridium Toxic shock Endometritis Myometritis Pregnancy Abortion Mifepristone Leukemoid Toxins Lethal toxin Clostridium sordellii Clostridium perfringens Gynecologic Obstetric Molecular diagnosis Pathogeneses 

Copyright information

© Springer Science+Business Media, LLC (outside the USA)  2011

Authors and Affiliations

  1. 1.Division of Reproductive HealthCenters for Disease Control and PreventionAtlantaUSA
  2. 2.Department of Pathology and Laboratory MedicineEmory University School of Medicine, Emory University HospitalAtlantaUSA

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