The role of Mycoplasma in upper respiratory infections
- 210 Downloads
Mycoplasma pneumoniae is a common cause of upper and lower respiratory tract infections. Pneumonia is the most clinically important manifestation, but tracheobronchitis and various nonspecific upper respiratory tract symptoms are more typically seen in clinical settings. M. pneumoniae can cause pharyngitis with or without concomitant lower respiratory tract involvement, but it is less commonly detected in other upper respiratory conditions such as otitis media, sinusitis, and the common cold. A variety of methods exist for laboratory diagnosis of M. pneumoniae infection, including culture, serology, and the polymerase chain reaction assay, but each has limitations. This article provides a summary of recent studies that have evaluated the role of M. pneumoniae in upper respiratory tract infections; a brief discussion of its cell biology, pathogenic mechanisms, and epidemiology; and recommendations for laboratory diagnosis and management.
KeywordsOtitis Medium Polymerase Chain Reaction Assay Acute Otitis Medium Nasal Polyp Antimicrob Agent
Unable to display preview. Download preview PDF.
References and Recommended Reading
- 19.Rivero Marcotegui M, Sanchez Rodriguez C, Cabal Soto S, Aizcorbe Garralda M: Lemierre’s syndrome and Mycoplasma pneumoniae. Ann Med Interna 2005, 22:541–543.Google Scholar
- 20.Clyde WA Jr: Mycoplasma pneumoniae infections of man. In The Mycoplasmas II. Human and Animal Mycoplasmas, vol 2. Edited by Tully JG, Whitcomb RF. New York: Academic Press; 1979: 275–306.Google Scholar
- 29.Waites KB, Bebear CM, Robertson JA, et al.: Cumitech 34, Laboratory Diagnosis of Mycoplasmal Infections. Edited by Nolte F. Washington, DC: American Society for Microbiology; 2001.Google Scholar
- 35.Templeton KE, Scheltinga SA, Graffelman AW, et al.: Comparison and evaluation of real-time PCR, real-time nucleic acid sequence-based amplification, conventional PCR, and serology for diagnosis of Mycoplasma pneumoniae. J Clin Microbiol 2003, 41:66–4371.Google Scholar
- 43.Pereyre S, Charron A, Renaudin H, et al.: First report of macrolide-resistant strains and description of a novel nucleotide sequence variation in the P1 adhesin gene in Mycoplasma pneumoniae clinical strains isolated in France over 12 years. J Clin Microbiol 2007, 45:3534–3539.PubMedCrossRefGoogle Scholar
- 48.Liu Y, Ye X, Zhang H, et al.: In vitro antimicrobial susceptibility of Mycoplasma pneumoniae strains isolated from Shanghai, China [abstract 43]. Presented at the 16th Congress of the International Organization for Mycoplasmology. Tianjin, China; July 6–11, 2008.Google Scholar