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Diagnosis and treatment of implant-associated septic arthritis and osteomyelitis

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Abstract

Implant-associated infections are caused by microorganisms growing in biofilms, rendering these infections difficult to diagnose and to eradicate. Delayed-onset low-grade infection is difficult to distinguish from aseptic failure, often presenting without signs of infection, but only with early loosening and persisting pain. A combination of criteria is needed for an accurate diagnosis: clinical signs and symptoms, laboratory signs of infection, microbiology, histology, and imaging. The treatment goals in prosthetic joint-associated infection are eradication of infection and an optimal functional result. The goal in internal fixation device-associated infection is consolidation of the fracture and avoidance of chronic osteomyelitis. Successful treatment requires an adequate surgical procedure combined with long-term antimicrobial therapy, ideally with an agent acting on adhering biofilm microorganisms. This article reviews the epidemiology, pathogenesis, diagnosis, and management of implant-associated infections, and presents pathogenesis and risk of hematogenous infection.

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  1. Medical University Clinic, Kantonsspital, CH-4410, Liestal, Switzerland

    Werner Zimmerli

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  1. Andrej Trampuz
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  2. Werner Zimmerli
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Correspondence to Werner Zimmerli.

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Trampuz, A., Zimmerli, W. Diagnosis and treatment of implant-associated septic arthritis and osteomyelitis. Curr Infect Dis Rep 10, 394–403 (2008). https://doi.org/10.1007/s11908-008-0064-1

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