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Pneumonitis in human cytomegalovirus infection

Current Infectious Disease Reports volume 8, pages 222–230 (2006)Cite this article

Abstract

Human cytomegalovirus (HCMV) is a β herpes virus with a double stranded DNA genome of 240kbp. The virus is prevalent and establishes a latent infection in most adults. HCMV is an opportunistic pathogen for patients with impaired cellular immunity. HCMV pneumonia is a common presentation of HCMV disease in immunocompromised patients. The incidence of HCMV pneumonitis can be as high as 90% in lung transplant recipients. This paper takes a fresh look at the challenging perspectives of molecular, immunologic, cellular, diagnostic, clinical, and therapeutic characteristics of HCMV infection as future targets for development of antiviral strategies.

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  1. James J. Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA

    Erik Langhoff MD, PhD

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  1. Erik Langhoff MD, PhD
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  2. Robert E. Siegel MD
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Correspondence to Erik Langhoff MD, PhD.

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Langhoff, E., Siegel, R.E. Pneumonitis in human cytomegalovirus infection. Curr Infect Dis Rep 8, 222–230 (2006). https://doi.org/10.1007/s11908-006-0063-z

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Keywords

  • Ganciclovir
  • Human Cytomegalovirus
  • Foscarnet
  • HCMV Infection
  • Bone Marrow Trans