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Mycoplasma genitalium

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Abstract

Mycoplasma genitalium was initially isolated from men with nongonococcal urethritis in 1980. Subsequent studies to assess the association of M. genitalium with human disease were inhibited however because on repeated attempts the organism proved extremely difficult to culture. Fortunately, the development and use of specific polymerase chain reaction assays allowed progress in this arena and provided evidence of the association between M. genitalium and urethritis, cervicitis, and endometritis. A serologic association has also been noted between M. genitalium antibody and salpingitis and tubal factor infertility. In addition, sexual transmission of M. genitalium in heterosexual partners has also been demonstrated. Currently, studies are underway to further assess these associations and provide additional information about the significance of this organism with regards to sexual transmission, infertility in women, and its association with other genital tract disease processes. Recent studies have suggested that M. genitalium-associated infections are best treated with azithromycin.

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References

  1. Frasier CM, Gocayne JD, White O, et al.: The minimal gene complement of Mycoplasma genitalium. Science 1995, 270:397–403.

    Article  Google Scholar 

  2. Razin S, Yogev D, Maot Y: Molecular biology and pathogenicity of mycoplasmas. Microbiol Mol Biol Rev 1998, 62:1094–1156.

    PubMed  CAS  Google Scholar 

  3. Uusküla A, Kohl PK: Genital mycoplasmas, including Mycoplasma genitalium, as sexually transmitted agents. Int J STD AIDS 2002, 13:79–85. This is a comprehensive summary and review of M. genitalium biology, epidemiology, and clinical manifestations.

    Article  PubMed  Google Scholar 

  4. Tully TG, Taylor-Robinson D, Cole RM, Rose DL: A newly discovered Mycoplasma in the human urogenital tract. Lancet 1981, 1:1288–1291.

    Article  PubMed  CAS  Google Scholar 

  5. Taylor-Robinson D: The history and role of Mycoplasma genitalium in sexually transmitted diseases. Genitourin Med 1995, 71:1–8.

    PubMed  CAS  Google Scholar 

  6. Taylor-Robinson D: Mycoplasma genitalium—an update. Int J STD AIDS 2002, 13:145–151. This excellent editorial reviews and updates of M. genitalium by one of the world renown mycoplasma and STD experts who originally reported the discovery of this organism and has contributed greatly to the body of medical literature pertaining to this organism.

    Article  PubMed  Google Scholar 

  7. Jensen JS: Mycoplasma genitalium: an etiological agent of urethritis and other sexually transmitted diseases. J Eur Acad Dermatol Venerol 2004, 18:1–11. This outstanding review by another one of the world-renowned experts in this field provides an excellent step-by-step review of information that provides evidence for the association of M. genitalium with disease entities using the modified Henle-Koch postulates.

    Article  Google Scholar 

  8. Taylor-Robinson D, Ainsworth JG, McCormack WM: Genital Mycoplasmas. In Sexually Transmitted Diseases. Edited byHolmes KK, Sparling, PF, Mardh P-A, et al. New York: McGraw-Hill; 2004:533–548.

    Google Scholar 

  9. McCormack WM, Lee YH, Zinner SH: Sexual experience and urethral colonization with genital mycoplasmas: a study in normal men. Ann Intern Med 1973, 78:696–698.

    PubMed  CAS  Google Scholar 

  10. McCormack WM, Almeida PC, Bailey PE, et al.: Sexual activity and vaginal colonization with genital mycoplasmas. JAMA 1972, 221:1375–1377.

    Article  PubMed  CAS  Google Scholar 

  11. de BarbeyracN, Bernet-Poggi C, Fébrer F, et al.: Detection of Mycoplasma pneumoniae and Mycoplasma genitalium in clinical samples by polymerase chain reaction. Clin Infect Dis 1993, 17(Suppl_1):83–89.

    Google Scholar 

  12. Tully JG, Rose DL, Baseman JN, et al.: Mycoplasma pneumoniae and Mycoplasma genitalium in synovial fluid isolate. J Clin Microbiol 1995, 33:1851–1855.

    PubMed  CAS  Google Scholar 

  13. Taylor-Robinson D, Gilroy CB, Horowitz S, et al.: Mycoplasma genitalium in the joints of two patients with arthritis. Euro J Clin Microbiol Infect Dis 1994, 13:1066–1069.

    Article  CAS  Google Scholar 

  14. Sakata H, Hayashi T, Hirano Y, et al.: Brain stem encephalitis due to Mycoplasma genitalium. Kansenshogaky Zasshi 1993, 67:500–504.

    CAS  Google Scholar 

  15. Tully JG, Taylor-Robinson D, Rose DL, et al.: Urogenital challenge of primate species with Mycoplasma genitalium and characteristics of infection induced in chimpanzees. J Infect Dis 1986, 153:1046–1054.

    PubMed  CAS  Google Scholar 

  16. Keane FEA, Thomas BJ, Gilroy CB, et al.: The association of Chlamydia trachomatis and Mycoplasma genitalium with non-gonococcal urethritis: observation on heterosexual men and their female partners. Int J STD AIDS 2000, 11:435–439.

    Article  PubMed  CAS  Google Scholar 

  17. Perez G, Skrunick JG, Denny TN, et al.: Herpes simplex type II and Mycoplasma genitalium as risk factors for heterosexual HIV transmission: report from the heterosexual transmission study. Int J Infect Dis 1998, 3:5–11.

    Article  PubMed  CAS  Google Scholar 

  18. Palmer HM, Gilroy CB, Rurr PM, Taylor-Robinson D: Development and evaluation of the polymerase chain reaction to detect Mycoplasma genitalium. FEMS Microbiol Lett 1991, 77:199–204.

    Article  CAS  Google Scholar 

  19. Jensen JS, Uldum SA, Søndergård-Anderson J, et al.: Polymerase chain reaction for detection of Mycoplasma genitalium in clinical samples. J Clin Microbiol 1991, 29:46–50.

    PubMed  CAS  Google Scholar 

  20. Horner PJ, Gilroy CB, Hay PE: Association of Mycoplasma genitalium with acute non-gonococcal urethritis. Lancet 1993, 342:582–585.

    Article  PubMed  CAS  Google Scholar 

  21. Jensen JS, Ørsum R, Dohn B, et al.: Mycoplasma genitalium: a cause of male urethritis? Genitourin Med 1993, 69:265–269.

    PubMed  CAS  Google Scholar 

  22. Jensen JS, Hansen HT, Lind K: Isolation of Mycoplasma genitalium strains from male urethra. J Clin Microbiol 1996, 34:286–291.

    PubMed  CAS  Google Scholar 

  23. Meada S, Tamaki M, Nakano M, et al.: Detection of Mycoplasma genitalium in patients with urethritis. J Urol 1998, 159:405–407.

    Article  Google Scholar 

  24. Gambini D, Decieva I, Lupica L, et al.: Mycoplasma genitalium in males with nongonococcal urethritis: prevalence and clinical efficacy of eradication. Sex Transm Dis 2000, 27:226–229.

    Article  PubMed  CAS  Google Scholar 

  25. Björnelius E, Lidnrink P, Jensen JS: Mycoplasma genitalium in non-gonococcal urethritis—a study I Swedish male STD patients. Int J STD AIDS 2000, 11:292–296.

    Article  PubMed  Google Scholar 

  26. Johannisson G, Enström Y, Löwhagen GB, et al.: Occurrence and treatment of Mycoplasma genitalium in patients visiting STD clinics in Sweden. Int J STD AIDS 2000, 11:324–326.

    Article  PubMed  CAS  Google Scholar 

  27. Totten PA, Schwartz MA, Sjöström KE, et al.: Association of Mycoplasma genitalium with nongonococcal urethritis in heterosexual men. J Infect Dis 2001, 183:269–276.

    Article  PubMed  CAS  Google Scholar 

  28. Horner PJ, Taylor-Robinson D: Mycoplasma genitalium and non-gonococcal urethritis. Lancet 1994, 343:790–791.

    Article  PubMed  CAS  Google Scholar 

  29. Horner PJ, Thomas B, Gilroy CB, et al.: Do all men attending departments of genitourinary medicine need to be screened for non-gonococcal urethritis? Int J STD AIDS 2002, 13:667–673.

    Article  PubMed  CAS  Google Scholar 

  30. Mena L, Wang X, Mroczkowski TF, Martin DH: Mycoplasma genitalium infections in asymptomatic men and men with urethritis attending a sexually transmitted diseases clinic in New Orleans. Clin Infect Dis 2002, 35:1167–1173.

    Article  PubMed  Google Scholar 

  31. Taylor-Robinson D, Furr PM, Hanna NF: Microbiological and serological study of non-gonococcal urethritis with special reference to Mycoplasma genitalium. Genitourin Med 1985, 61:319–324.

    PubMed  CAS  Google Scholar 

  32. Hooton TM, Roberts MC, Roberts PL, et al.: Prevalence of Mycoplasma genitalium determined by DNA probe in men with urethritis. Lancet 1988, 1:266–268.

    Article  PubMed  CAS  Google Scholar 

  33. Kreiger JN, Riley DE, Roberts MC, Berger RE: Prokaryotic DNA sequences in patients with chronic idiopathic prostatitis. J Clin Microbiol 1996, 34:3120–3128.

    Google Scholar 

  34. Taylor-Robinson D, Furr PM, Tully JG, et al.: Animal models of Mycoplasma genitalium urogenital infection. Isr J Med Sci 1987, 23:561–564.

    PubMed  CAS  Google Scholar 

  35. Møller BR, Taylor-Robinson D, Furr PM, Freundt EA: Acute upper genital-tract disease in femaole monkeys provoked experimentally by Mycoplasma genitalium. Br J Exp Pathol 1985, 66:417–426.

    PubMed  Google Scholar 

  36. Collier AM, Carson JL, Hu PC, et al.: Attachment of Mycoplasma genitalium to the ciliated epithelium of human fallopian tubes. In Recent Advances in Mycoplasmology. Edited by Stanek G, Cassell GH, Tully JG, Whitcomb RF. Stuttgart: Gustav Fischer Verlag; 1990:730–732.

    Google Scholar 

  37. Uno M, Deguchi T, Komeda H, et al.: Mycoplasma genitalium in the cervices of Japanese women. Sex Transm Dis 1997, 24:284–286.

    Article  PubMed  CAS  Google Scholar 

  38. Manhart LE, Critchlow CW, Holmes KK, et al.: Mucopurulent cervicitis and Mycoplasma genitalium. J Infect Dis 2003, 187:650–657.

    Article  PubMed  Google Scholar 

  39. Møller BR, Taylor-Robinson D, Furr PM: Serological evidence implicating Mycoplasma genitalium in pelvic inflammatory disease. Lancet 1984, 1:1102–1103.

    Article  PubMed  Google Scholar 

  40. Simms I, Eastick K, Mallinson H, et al.: Associations between Mycoplasma genitalium, Chlamydia trachomatis, and pelvic inflammatory disease. Sex Transm Infect 2003, 79:154–156.

    Article  PubMed  CAS  Google Scholar 

  41. Cohen CR, Manhart LE, Bukusi EA, et al.: Association between Mycoplasma genitalium and acute endometritis. Lancet 2002, 359:765–766.

    Article  PubMed  Google Scholar 

  42. Keane FE, Thomas BJ, Gilroy CB, et al.: The association of Mycoplasma hominis, Ureaplasma urealyticum, and Mycoplasma genitalium with bacterial vaginosis: observations on heterosexual women and their male partners. Int J STD AIDS 2000, 11:356–360.

    Article  PubMed  CAS  Google Scholar 

  43. Lu GC, Schwebke JF, Duffy LB, et al.: Midtrimester vaginal Mycoplasma genitalium in women with subsequent spontaneous preterm birth. Am J Obstet Gynecol 2001, 185:163–165.

    Article  PubMed  CAS  Google Scholar 

  44. Labbe AC, Frost E, Deslandes S, et al.: Mycoplasma genitalium is not associated with adverse outcomes of pregnancy in Guinea-Bissau. Sex Transm Infect 2002, 78:289–291.

    Article  PubMed  Google Scholar 

  45. Clausen HF, Fedder J, Drasbek M, et al.: Serological investigation of Mycoplasma genitalium in infertile women. Hum Reprod 2001, 16:1866–1874.

    Article  PubMed  CAS  Google Scholar 

  46. Ma L, Martin DH: Single-nucleotide polymorphisms in the rRNA operon and variable numbers of tandem repeats in the lipoprotein gene among Mycoplasma genitalium strains from clinical specimens. J Clin Microbiol 2004, 52:4876–4878.

    Article  CAS  Google Scholar 

  47. Dupin N, Bijaoui G, Schwarzinger M, et al.: Detection and quantification of Mycoplasma genitalium in male patients with urethritis. Clin Infect Dis 2003, 37:602–605.

    Article  PubMed  Google Scholar 

  48. Jurstrand M, Jensen JS, Fredlund H, et al.: Detection of Mycoplasma genitalium in urogenital specimens by real-time PCR and by conventional PCR assay. J Med Microbiol 2005, 54:23–29.

    Article  PubMed  CAS  Google Scholar 

  49. Jensen JS, Bjornelius E, Dohn B, Lidbrink P: Use of TaqMan 5′ nuclease real-time PCR for quantitative detection of Mycoplasma genitalium DNA in males with and without urethritis who were attendees at a sexually transmitted disease clinic. J Clinic Microbiol 2004, 42:683–692.

    Article  CAS  Google Scholar 

  50. Kokotovic B, Friis NF, Jensen JS, Ahrens P: Amplified-fragment length polymorphism fingerprinting of Mycoplasma species. J Clin Microbiol 1999, 37:3300–3307.

    PubMed  CAS  Google Scholar 

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  1. Department of Medicine, Section of Infectious Diseases, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, 70112, New Orleans, LA, USA

    Stephanie N. Taylor MD

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Taylor, S.N. Mycoplasma genitalium . Curr Infect Dis Rep 7, 453–457 (2005). https://doi.org/10.1007/s11908-005-0047-4

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  • DOI: https://doi.org/10.1007/s11908-005-0047-4

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