Skip to main content

Advertisement

Log in

Abstract

Yersinia pestis is a gram-negative bacillus that can cause pneumonia if inhaled. Secondary person-to-person spread of infection can develop. Aerosolization of this organism as a weapon of biological terror could potentially cause many thousands of casualties, mass social disruption, and widespread fear. Plague pneumonia is treatable if recognized early but still carries a 50% to 60% mortality rate. Delay in therapy is associated with 100% mortality rates. Prophylaxis of exposed persons with oral antibiotics is indicated. There is no protective vaccine currently available.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References and Recommended Reading

  1. Butler T: Yersinia infections: ventennial of the discovery of the plague bacillus. Clin Infect Dis 1994, 19:655–663.

    PubMed  CAS  Google Scholar 

  2. Cleri DJ, Vernaleo JR, Lombardi LJ, et al.: Plague pneumonia: Disease caused by Yersinia pestis. Seminar Respir Infect 1997, 12:12–23.

    CAS  Google Scholar 

  3. Centers for Disease Control and Prevention: Human plague - India 1994. Morbid Mortal Wkly Rprt 1994, 43:689–691.

    Google Scholar 

  4. Barnes AM: Surveillance and control of bubonic plague in the United States. Symp Zool Soc Lond 1982, 50:237–270.

    Google Scholar 

  5. Welty TK, Grabman J, Kompare A, et al.: Nineteen cases of plague in Arizona - A spectrum including ecthyma gangrenosa due to plague and plague in pregnancy. West J Med 1985, 142:641–646.

    PubMed  CAS  Google Scholar 

  6. Myer K: Pneumonic plague. Bacteriol Rev 1961, 25:249–261.

    Google Scholar 

  7. Centers for Disease Control and Prevention: Public health emergency preparedness and response. Accessible at http:// www.bt.cdc.gov. A continuously updated website providing epidemiologic and treatment information regarding bioterrorism issues, threats, and actual occurences.

  8. Inglesby TV, Dennis DT, Henderson DA, et al.: Plague as a biological weapon: medical and public health management. JAMA 2000, 283:2281–2291. An encyclopedic and authoritative review of the use of plague as a biological weapon.

    Article  PubMed  CAS  Google Scholar 

  9. US Army Medical Research Institute of Infectious Diseases: Medical Management of Biological Casualties, edn 3. Fort Detrick, MD; 1998:40–43. An excellent pocket-sized book written in a clear, matter-of-fact style regarding the diagnosis and managemnet of biological weapons casualties.

  10. Relman DA, Olson JE: Bioterrorism preparedness: what practitioners need to know. Infect Med 2001, 18:497–514. An up-to-date, practical review of bioterrorism agents, both clinical manifestations and management.

    Google Scholar 

  11. Health Aspects of Chemical and Biological Weapons. Geneva, Switzerland: World Health Organization; 1970:98-109.

  12. Centers for Disease Control and Prevention: Fatal human plague - Arizona and Colorado, 1996. Morbid Mortal Wkly Rprt 1997, 46:617–620.

    Google Scholar 

  13. Swartz MN: Recognition and management of anthrax - An update. N Engl J Med 2001, 345:1621–1626.

    Article  PubMed  CAS  Google Scholar 

  14. Jefferson T, Demicheli V, Pratt M: Vaccines for preventing plague (Cochrane review). In The Cochrane Library, Issue 2. Oxford: Update Software; 2001. A detailed analysis of the available data regarding plague vaccine effectiveness.

    Google Scholar 

  15. Inglesby TV, Grossman R, O’Toole T: A plague on your city: Observations from TOPOFF. Clin Infect Dis 2001, 32:436–445. A narrative of the TOPOFF exercise that describes the potential scope of a plague attack as well as the problems the state authorities, federal government, and local health care system had in responding to it effectively in a prompt, coordinated manner.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gradon, J.D. Plague pneumonia. Curr Infect Dis Rep 4, 244–248 (2002). https://doi.org/10.1007/s11908-002-0087-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11908-002-0087-y

Keywords

Navigation