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Recent clinical trials: A critical appraisal

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Conclusions

The clear message from these trials from the 1990s is that crucial questions often are being addressed by studies that contain important flaws in design and data interpretation. Investigators involved in on-going studies in hypertension are urged to review critically aspects of their study design and plans for later analysis to avoid some of the problems outlined in this overview.

It is hoped that large-scale outcome trials such as the Anglo-Scandinavian Cardiac Outcomes Trial (ACSOT) and the Antihypertensive and Lipid-Lowering Heart Attack Prevention Trial (ALLHAT) will provide definitive answers to the questions of optimal treatments for the prevention of coronary heart disease and other cardiovascular end points in hypertension in the millennium.

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References and Recommended Reading

  1. 1999 World Health Organization: International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines Sub-committee. J Hypertens 1999, 17:151–183.

    Google Scholar 

  2. Staessen JA, Fagard R, Thija L, et al.: Ramdomized doubleblind comparison of placebo and active treatment for older patients with isolated systolic hypertension. Lancet 1997, 350:757–764.

    Article  PubMed  CAS  Google Scholar 

  3. SHEP Co-operative Research Group: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991, 265:3255–3264.

    Article  Google Scholar 

  4. MRC Working Party Medical Research Council: Trial of treatment in older adults: principal results. BMJ 1992, 304:405–412.

    Article  Google Scholar 

  5. Hansson L, Zanchetti S, Carruthers S, et al.: Effects of intensive blood pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998, 351:1755–1762.

    Article  PubMed  CAS  Google Scholar 

  6. UKPDS: Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 1998, 317:703–713.

    Google Scholar 

  7. UKPDS: Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. BMJ 1998, 317:713–720.

    Google Scholar 

  8. Hansson L, Lindholm LH, Niskanen L, et al.: Principal results of the Captopril Prevention Project (CAPP) randomised trial. Lancet 1999, 353:611–616.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Imperial College School of Medicine, NHLI Division, Department of Clinical Pharmacology and Epidemiology, Queen Elizabeth the Queen Mother Wing, St. Mary’s Hospital, W2 1NY, London, UK

    Peter S. Sever PhD, FRCP, FESC

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  1. Peter S. Sever PhD, FRCP, FESC
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Sever, P.S. Recent clinical trials: A critical appraisal. Current Science Inc 1, 333–336 (1999). https://doi.org/10.1007/s11906-999-0042-5

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  • DOI: https://doi.org/10.1007/s11906-999-0042-5

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