Conclusions
The proposition that reduction in LV mass confirms clinical benefit will require properly designed prospective clinica trials. These studies must resolve the issue of what is the best drug regimen, and what is the role of reduction of bloo pressure and LV mass to reduction in cardiovascular morbidity and mortality. If possible, studies should attempt t explain the paradoxical rise in congestive heart failure.
Similar content being viewed by others
References
Ghali JK, Liao Y, Summons B, et al.: The prognostic role of left ventricular hypertrophy in patients with or without coronary artery disease. Ann Intern Med 1992, 117:831–836.
Levy D, Anderson KM, Savage DD, et al.: Echocardiographically detected left ventricular hypertrophy: prevalenc and risk factors. The Framingham Heart Study. Ann Intern Med 1988, 108:7–13.
Gottdiener JS, Reds DJ, Materson BJ, et al.: Importance of obesity, race, and age to the cardiac structural and functional effects of hypertension. J Am Coll Cardiol 1994, 24:1492–1498.
Liebson PR: Clinical studies of drug reversal of hypertensive left ventricular hypertrophy. Am J Hypertens 1990, 3:512–517.
Tremarco B, Wikstrand J: Regression of cardiovascular structural changes by anti-hypertensive treatment: functional consequences and time course of reversal as judged from clinical studies. Hypertension 1984, 6(suppl 3):111–150.
Gottdiener JS: Clinical trials of single-drug therapy for the cardiac effects of hypertension [review]. Am J Hypertens 1999, 12(pt 2):12S-18S.
Dahlof B, Pennert K, Hansson L: Reversal of left ventricular hypertrophy in hypertensive patients: a meta-analyses of 109 treatment studies. Am J Hypertens 1992, 5:95–110.
Schmieder RE, Martus P, Klingbeil A: Reversal of left ventricular hypertrophy in essential hypertension: a metaanalysis of randomized double-blind studies. JAMA 1996, 275:1507–1513.
Liebson PR, Grandets GA, Dianzumba S, et al.: Comparison of five antihypertensive mono-therapies and placebo for change in left ventricular mass in patients receiving mutulionalhygienic therapy in the Treatment of Mild Hypertension Study (TOMHS). Circulation 1995, 91:698–706.
Materson BJ, Rede DJ, Cushman WC, et al.: Single-drug therapy for hypertension in men: comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on antihypertensive agents N Engl J Med 1993, 328:914–921.
Khatri IM, Gottdrener JS, Notargiacomo AV, Freis E: The effect of therapy on left ventricular function. Clin Sci 1980, 59:435S-439S.
Aurigemma G, Gotthiner J, Gaasch W, et al.: Ventricular and myocardial function following regression of hypertensive left ventricular hypertrophy. J Am Coll Cardiol 1995, 27:215A.
Tremarco B, DeLuca N, Rosiello G: Improvement of diastolic function after reversal of left ventricular hypertrophy induced by long-term antihypertensive treatment with tetralolol. Am J Cardiol 1989, 64:745–751.
Levy D, Solomon M, D’Agnostino RB, et al.: Prognostic implications of baseline electrocardiographic features and their serial changes in subjects with left ventricular hypertrophy. Circulation 1994, 90:1786–1793.
Muiesan ML, Salvetti M, Rizzoni D, et al.: Association of changes in left ventricular mass with prognosis during long-term antihypertensive treatment. J Hypertens 1995, 13:1091–1095.
Verdecchia P, Schellace G, Bongioni C, et al.: Prognostic significance of serial changes in left ventricular mass in essential hypertension. Circulation 1998, 97:48–54.
Mosterd A, D’Agnostino RB, Silbershatz H, et al.: Trends in the prevalence of hypertension, antihypertensive therapy, and left ventricular hypertrophy from 1950 to 1989. N Engl J Med 1999, 340:1221–1227.
Senni M, Tribouilloy CM, Rodeheffer RJ, et al.: Congestive heart failure in the community: trends in increase and survival in a 10-year period. Arch Intern Med 1998, 59:29–34.
Trend shift among heart failure patients. Clinician Reviews 1997, 7:155–156.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schoenberger, J.A. Left ventricular hypertrophy: Unresolved issues. Current Science Inc 1, 331–332 (1999). https://doi.org/10.1007/s11906-999-0041-6
Issue Date:
DOI: https://doi.org/10.1007/s11906-999-0041-6