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The renin-angiotensin system antagonism in the treatment of hypertension

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Abstract

The effective treatment of hypertension is associated with improved mortality and morbidity from diseases such as stroke, congestive heart failure, and renal failure. Use of medications that target the renin-angiotensin system for the treatment of hypertension can often achieve the desired decrease in blood pressure while causing a minimum of unwanted side effects. In this paper, the principles of the renin-angiotensin system antagonism are described. The approach to using these medications is discussed with special attention to specific indications as well as common side effects.

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References

  1. Bertel O, Buhler F, Kiowski W: Decreased beta-adrenoreceptor responsiveness as related to age, blood pressure, and plasma catecholamines in patients with essential hypertension. Hypertension 1980, 2:130–138.

    PubMed  CAS  Google Scholar 

  2. Goldberg J, Flowerdew G, Smith E, et al.: Factors associated with age-related macular degeneration: an analysis of data from the first national Health and Nutrition Examination Survey. Am J Epidemiol 1980, 128:700–710.

    Google Scholar 

  3. Bisognano J, Weder A: Recognition and treatment of hypertensive heart disease in the older person. Clin Geriatr 1997, 5:33–50.

    Google Scholar 

  4. JNC VI: Sixth Report of the Joint National Commission on Prevention, Detection and Treatment of High Blood Pressure. Arch Intern Med 1997, 157:2413–2446.

    Article  Google Scholar 

  5. Gavras H: Angiotensin-converting enzyme inhibition and its impact on cardiovascular disease. Circulation 1990, 81:381–388.

    PubMed  CAS  Google Scholar 

  6. Zimmerman B, Raich PC, Vavrek R, Stewart J: Bradykinin contribution to renal blood flow effect of angiotensinconverting enzyme inhibitor in the conscious sodium restricted dog. Circ Res 1990, 66:234–240.

    PubMed  CAS  Google Scholar 

  7. Bisognano J, Horwitz L: Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor antagonist for severe, refractory essential hypertension. West J Med 1998, 168:272–274.

    PubMed  CAS  Google Scholar 

  8. Boulet L, Milot J, Lampron N, Lacourciere Y: Pulmonary function and airway responsiveness during long-term therapy with captopril. JAMA 1989, 261:413–416.

    Article  PubMed  CAS  Google Scholar 

  9. The SOLVD Investigators: Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991, 35:293–302.

    Google Scholar 

  10. Dunn F, Oigman W, Ventura H: Enalapril improves systemic and renal hemodynamics and allows regression of left ventricular mass in essential hypertension. Am J Cardiol 1984, 53:105–108.

    Article  PubMed  CAS  Google Scholar 

  11. Wagstaff AJ, Davis R, McTavish D: Fosinopril: a reappraisal of its pharmacology and therapeutic efficacy in essential hypertension. Drugs 1996, 51:777–791.

    PubMed  CAS  Google Scholar 

  12. Goodfriend TL, Elliott ME, Catt KJ: Angiotensin receptors and their antagonists. N Engl J Med 1996, 334:1649–1654.

    Article  PubMed  CAS  Google Scholar 

  13. Hanssens M, Keirse MJ, Vankelecom F, Van Assche FA: Fetal and neonatal effects of treatment with angiotensinconverting enzyme inhibitors in pregnancy. Obstet Gynecol 1991, 128–135.

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Bisognano, J.D., Cody, R.J. The renin-angiotensin system antagonism in the treatment of hypertension. Current Science Inc 1, 275–277 (1999). https://doi.org/10.1007/s11906-999-0033-6

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  • DOI: https://doi.org/10.1007/s11906-999-0033-6

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