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Slow on the Draw—ED Management of Elevated BP in Older Adults

  • Hypertension and Emergency Medicine (J Miller, Section Editor)
  • Published:
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Abstract

Purpose of Review

The purpose of this study is to review data surrounding the emergency department management of elevated blood pressure in older adults, including the management of hypertensive crisis and outpatient management of markedly elevated blood pressure.

Recent Findings

Acute lowering of blood pressure in older adults with markedly elevated blood pressure may lead to serious complications without improvements in hospital length of stay, return visits, or mortality. Older adults presenting with elevated blood pressures without evidence of end-organ damage should be referred for outpatient management of their blood pressure. Treatment of hypertensive emergency should follow standard guidelines with additional considerations for aging physiology.

Summary

Acute lowering of elevated blood pressure in older adults without evidence of end-organ damage has the potential for harm. If the emergency physician opts to acutely treat, they should consider the increased risk of side effects in older adults and avoid Beers list medications including short-acting nifedipine and clonidine.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Murray CJL, Aravkin AY, Zheng P, Abbafati C, Abbas KM, Abbasi-Kangevari M, et al. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of disease study 2019. The Lancet. 2020;396:1223–49.

    Article  Google Scholar 

  2. Singh GM, Danaei G, Farzadfar F, Stevens GA, Woodward M, Wormser D, et al. The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis. Wang G, editor. PLoS One. 2013;8:e65174.

  3. Dai H, Bragazzi NL, Younis A, Zhong W, Liu X, Wu J, et al. Worldwide trends in prevalence, mortality, and disability-adjusted life years for hypertensive heart disease from 1990 to 2017. Hypertension. 2021;77:1223–33.

    Article  CAS  PubMed  Google Scholar 

  4. Zhou B, Perel P, Mensah GA, Ezzati M. Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension. Nat Rev Cardiol. 2021;18:785–802.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Oliveros E, Patel H, Kyung S, Fugar S, Goldberg A, Madan N, et al. Hypertension in older adults: assessment, management, and challenges. Clin Cardiol. 2020;43:99–107.

    Article  PubMed  Google Scholar 

  6. McNaughton CD, Self WH, Zhu Y, Janke A, Storrow AB, Levy P. Incidence of hypertension-related emergency department visits in the United States, 2006–2012. Am J Cardiol. 2015;116:1717–23.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Raisi‐Estabragh Z, Kobo O, Elbadawi A, Velagapudi P, Sharma G, Bullock‐Palmer RP, et al. Differential patterns and outcomes of 20.6 million cardiovascular emergency department encounters for men and women in the United States. J Am Heart Assoc. 2022;11:e026432.

  8. Miller J, McNaughton C, Joyce K, Binz S, Levy P. Hypertension management in emergency departments. Am J Hypertens. 2020;33:927–34.

    PubMed  PubMed Central  Google Scholar 

  9. Franklin SS, Larson MG, Khan SA, Wong ND, Leip EP, Kannel WB, et al. Does the relation of blood pressure to coronary heart disease risk change with Aging?: The Framingham Heart Study. Circulation. 2001;103:1245–9.

    Article  CAS  PubMed  Google Scholar 

  10. Fryar CD, Ostchega Y, Hales CM, Zhang G, Kruszon-Moran D. hypertension prevalence and control among adults: United States, 2015–2016. NCHS Data Brief. 2017;1–8.

  11. Wolf SJ, Lo B, Shih RD, Smith MD, Fesmire FM. Clinical policy: critical issues in the evaluation and management of adult patients in the emergency department with asymptomatic elevated blood pressure. Ann Emerg Med. 2013;62:59–68.

    Article  PubMed  Google Scholar 

  12. Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation [Internet]. 2018 [cited 2023 Feb 6];138. Available: https://www.ahajournals.org/doi/10.1161/CIR.0000000000000597.

  13. Anker D, Santos-Eggimann B, Zwahlen M, Santschi V, Rodondi N, Wolfson C, et al. Blood pressure control and complex health conditions in older adults: impact of recent hypertension management guidelines. J Hum Hypertens. 2021;35:280–9.

    Article  PubMed  Google Scholar 

  14. Burnier M, Wuerzner G. Pathophysiology of hypertension. In: Jagadeesh G, Balakumar P, Maung-U K, editors. Pathophysiol Pharmacother Cardiovasc Dis [Internet]. Cham: Springer International Publishing; 2015 [cited 2023 Mar 29]. p. 655–83. Available from: https://doi.org/10.1007/978-3-319-15961-4_31.

  15. Lionakis N. Hypertension in the elderly. World J Cardiol. 2012;4:135.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Alshami M, Romero C, Avila A, Varon J. Management of hypertensive crises in the elderly. J Geriatr Cardiol. 2018;15:504–12.

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Robles NR, Macias JF. Hypertension in the elderly. Cardiovasc Hematol Agents Med Chem. 2014;12:136–45.

    Article  CAS  Google Scholar 

  18. Talle MA, Ngarande E, Doubell AF, Herbst PG. Cardiac complications of hypertensive emergency: classification, diagnosis and management challenges. J Cardiovasc Dev Dis. 2022;9:276.

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 2003;42:1206–52.

    Article  CAS  PubMed  Google Scholar 

  20. Pinna G, Pascale C, Fornengo P, Arras S, Piras C, Panzarasa P, et al. Hospital admissions for hypertensive crisis in the emergency departments: a large multicenter Italian study. PLoS One. 2014;9:e93542.

    Article  ADS  PubMed  PubMed Central  Google Scholar 

  21. Watson K, Broscious R, Devabhakthuni S, Noel ZR. Focused update on pharmacologic management of hypertensive emergencies. Curr Hypertens Rep. 2018;20:56.

    Article  PubMed  Google Scholar 

  22. Balahura A-M, Moroi Ștefan-I, Scafa-Udrişte A, Weiss E, Japie C, Bartoş D, et al. The management of hypertensive emergencies—is there a “magical” prescription for all? J Clin Med. 2022;11:3138.

  23. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth joint national committee (JNC 8). JAMA. 2014;311:507.

    Article  CAS  PubMed  Google Scholar 

  24. Levy PD, Mahn JJ, Miller J, Shelby A, Brody A, Davidson R, et al. Blood pressure treatment and outcomes in hypertensive patients without acute target organ damage: a retrospective cohort. Am J Emerg Med. 2015;33:1219–24.

    Article  PubMed  Google Scholar 

  25. McAlister FA, Youngson E, Rowe BH. Elevated blood pressures are common in the emergency department but are they important? A retrospective cohort study of 30,278 Adults. Ann Emerg Med. 2021;77:425–32.

    Article  PubMed  Google Scholar 

  26. • Rastogi R, Sheehan MM, Hu B, Shaker V, Kojima L, Rothberg MB. Treatment and outcomes of inpatient hypertension among adults with noncardiac admissions. JAMA Intern Med. 2021;181:345–52. Acute inpatient management of asymptomatic hypertension associated with increased risk of adverse outcomes without improvement in mortality at 30 days.

  27. •• Mohandas R, Chamarthi G, Bozorgmehri S, Carlson J, Ozrazgat-Baslanti T, Ruchi R, et al. Pro re nata antihypertensive medications and adverse outcomes in hospitalized patients: a propensity-matched cohort study. Hypertension. 2021;78:516–24. Acute inpatient treatment of asymptomatic hypertension associated with increased risk of adverse outcomes, increased in hospital mortality, increased length of stay.

  28. •• Anderson TS, Herzig SJ, Jing B, Boscardin WJ, Fung K, Marcantonio ER, et al. Clinical outcomes of intensive inpatient blood pressure management in hospitalized older adults. JAMA Intern Med [Internet]. 2023 [cited 2023 Jun 6]; Available from: https://doi.org/10.1001/jamainternmed.2023.1667. Acute inpatient management of asymptomatic hypertension is associated with increased risk of adverse events in both IV and oral antihypertensives, with a higher risk in IV options.

  29. Winders WT, Ariizumi R, Hart K, Elder N, Lyons M, Lindsell C, et al. Hypertensive ED patients: missed opportunities for addressing hypertension and facilitating outpatient follow-up. Am J Emerg Med. 2018;36:2268–75.

    Article  PubMed  Google Scholar 

  30. Atzema CL, Yu B, Schull MJ, Jackevicius CA, Ivers NM, Lee DS, et al. Physician follow-up and long-term use of evidence-based medication for patients with hypertension who were discharged from an emergency department: a prospective cohort study. CMAJ Open. 2018;6:E151–61.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Zhang W, Zhang S, Deng Y, Wu S, Ren J, Sun G, et al. Trial of intensive blood-pressure control in older patients with hypertension. N Engl J Med. 2021;385:1268–79.

    Article  CAS  PubMed  Google Scholar 

  32. Sprint Research Group. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373:2103–16.

    Article  Google Scholar 

  33. Karayiannis, CC. Hypertension in the older person: is age just a number? Intern Med J [Internet]. 2022 [cited 2023 Feb 10];52. Available from: https://onlinelibrary.wiley.com/doi/10.1111/imj.15949.

  34. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ Can Med Assoc J J Assoc Medicale Can. 2005;173:489–95.

    Article  Google Scholar 

  35. Benetos A, Petrovic M, Strandberg T. Hypertension management in older and frail older patients. Circ Res. 2019;124:1045–60.

    Article  CAS  PubMed  Google Scholar 

  36. Moreland B. Trends in nonfatal falls and fall-related injuries among adults aged ≥65 years — United States, 2012–2018. MMWR Morb Mortal Wkly Rep [Internet]. 2020 [cited 2023 Mar 2];69. Available from: https://www.cdc.gov/mmwr/volumes/69/wr/mm6927a5.htm.

  37. Tinetti ME, Han L, Lee DSH, McAvay GJ, Peduzzi P, Gross CP, et al. Antihypertensive medications and serious fall injuries in a nationally representative sample of older adults. JAMA Intern Med. 2014;174:588–95.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Allgaier J, Emmich M, Rastegar V, Stefan MS, Lagu T. Hypertensive urgency or emergency? The use of intravenous medications in hospitalized hypertensive patients without organ dysfunction. Heart Lung. 2020;49:824–8.

    Article  PubMed  Google Scholar 

  39. Maloberti A, Cassano G, Capsoni N, Gheda S, Magni G, Azin GM, et al. Therapeutic approach to hypertension urgencies and emergencies in the emergency room. High Blood Press Cardiovasc Prev. 2018;25:177–89.

    Article  PubMed  Google Scholar 

  40. Miller JB, Arter A, Wilson SS, Janke AT, Brody A, Reed B, et al. Appropriateness of bolus antihypertensive therapy. West J Emerg Med. 2017;18:957–62.

  41. Qaseem A, Wilt TJ, Rich R, Humphrey LL, Frost J, Forciea MA, et al. Pharmacologic treatment of hypertension in adults aged 60 years or older to higher versus lower blood pressure targets: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians. Ann Intern Med. 2017 [cited 2023 Mar 30]; Available from: https://www.acpjournals.org/doi/10.7326/M16-1785.

  42. Tocci G, Presta V, Volpe M. Hypertensive crisis management in the emergency room: time to change? J Hypertens. 2020;38:33–4.

    Article  CAS  PubMed  Google Scholar 

  43. Zampaglione B, Pascale C, Marchisio M, Cavallo-Perin P. Hypertensive urgencies and emergencies. Hypertension. 1996;27:144–7.

    Article  CAS  PubMed  Google Scholar 

  44. Janke AT, McNaughton CD, Brody AM, Welch RD, Levy PD. Trends in the incidence of hypertensive emergencies in US emergency departments From 2006 to 2013. J Am Heart Assoc Cardiovasc Cerebrovasc Dis. 2016;5: e004511.

    Article  Google Scholar 

  45. Benenson I, Waldron FA, Jadotte YT, Dreker MP, Holly C. Risk factors for hypertensive crisis in adult patients: a systematic review. JBI Evid Synth. 2021;19:1292–327.

  46. Astarita A, Covella M, Vallelonga F, Cesareo M, Totaro S, Ventre L, et al. Hypertensive emergencies and urgencies in emergency departments: a systematic review and meta-analysis. J Hypertens. 2020;38:1203–10.

    Article  CAS  PubMed  Google Scholar 

  47. Miller JB, Kinni H, Amer A, Levy PD. Therapies to reduce blood pressure acutely. Curr Hypertens Rep. 2016;18:43.

    Article  PubMed  Google Scholar 

  48. Panel B, the 2023 AGSBCUE. American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults. J Am Geriatr Soc. [cited 2023 Jun 13];n/a. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/jgs.18372.

  49. Kulkarni A. Older adults and hypertension: beyond the 2017 guideline for prevention, detection, eval and management. Am Coll Cardiol. 2020.

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Correspondence to Lauren Cameron-Comasco.

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Eurick-Bering, K., Todd, B. & Cameron-Comasco, L. Slow on the Draw—ED Management of Elevated BP in Older Adults. Curr Hypertens Rep 26, 107–117 (2024). https://doi.org/10.1007/s11906-023-01284-y

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