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Hypoxia-Inducible Factor 1 and Preeclampsia: A New Perspective

Current Hypertension Reports volume 24, pages 687–692 (2022)Cite this article

Abstract

Purpose of Review

Preeclampsia (PE) is a serious and distinct type of pregnancy-induced hypertension, with an incidence of 2–8% worldwide. PE is defined as pregnancy-related hypertension with proteinuria and peripheral edema after 20 weeks of gestation. Hypoxic placenta triggers the release of inflammatory and humoral substances into maternal circulation, leading to induction of oxidative stress, lipid peroxidation, endothelial dysfunction, and peripheral vasoconstriction. The objective of the present narrative review was to find the association between PE and hypoxia-inducible factor 1 (HIF-1) in pregnant women from a new perspective.

Recent Findings

HIF-1 is the key transcription factor that regulates cellular responses to hypoxia and low oxygen tension. HIF-1α is involved in the differentiation and growth of the placenta mainly in the first and second trimesters. During normal gestation, HIF-1α responds to the alterations in oxygen tension, cytokine, and angiogenic factors release. HIF-1α is considered a key biomarker of placental function and vascularization during pregnancy.

Summary

HIF-1α plays a crucial role in the pathogenesis of PE through activation of anti-angiogenic and inhibition of proangiogenic factors. As well, HIF-1α increases the expression of the p38MAPK and NLRP3 inflammasomes, which promote placental inflammation and dysfunction. HIF-1α acts as a potential link between inflammatory signaling pathways and the development of PE.

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Data Availability

Not applicable.

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Acknowledgements

The authors would like to thank Mustansiriyah University, Baghdad, Iraq, for the great support of scientific research.

Author information

Author notes

  1. Sarah M. Albogami and Hayder M. Al-kuraishy contributed equally to this work.

Authors and Affiliations

  1. Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia

    Sarah M. Albogami, Mohammed Alorabi & Saqer S. Alotaibi

  2. Department of Pharmacology, Toxicology and Medicine College of Medicine, Al-Mustansiriyah University, P.O. Box 14132, Baghdad, Iraq

    Hayder M. Al-kuraishy & Ali I. Al-Gareeb

  3. Department of Gynecology and Obstetrics, College of Medicine, Al-Mustansiriyah University, P.O. Box 14132, Baghdad, Iraq

    Thabat J. Al-Maiahy

  4. Department of Clinical Pharmacology, Medicine and Therapeutic, Medical Faculty, College of Medicine, Al Mustansiriyah University, P.O. Box 14132, Baghdad, Iraq

    Ali K. Al-Buhadily

  5. Smartox Biotechnology, 6 rue des Platanes, 38120, Saint-Egrève, France

    Michel De Waard

  6. L’institut Du Thorax, CNRS, Univ Nantes, 44007, InsermNantes, France

    Michel De Waard

  7. LabEx Ion Channels, Université de Nice Sophia-Antipolis, Science & Therapeutics, 06560, Valbonne, France

    Michel De Waard

  8. Institut de Neurophysiopathologie (INP), UMR 7051, Faculté Des Sciences Médicales Et Paramédicales, Aix-Marseille Université, CNRS, 27 Bd Jean Moulin, 13005, Marseille, France

    Jean-Marc Sabatier

  9. Department of Pathology, Faculty of Veterinary Medicine, Matrouh University, Marsa Matruh, 51744, Egypt

    Hebatallah M. Saad

  10. Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, Egypt

    Gaber El-Saber Batiha

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  1. Sarah M. Albogami
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The authors equally participated in the development of the manuscript and provided their final approval of all the content and submission for publication.

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Correspondence to Hebatallah M. Saad or Gaber El-Saber Batiha.

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Albogami, S.M., Al-kuraishy, H.M., Al-Maiahy, T.J. et al. Hypoxia-Inducible Factor 1 and Preeclampsia: A New Perspective. Curr Hypertens Rep 24, 687–692 (2022). https://doi.org/10.1007/s11906-022-01225-1

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Keywords

  • Preeclampsia
  • Hypoxia-inducible factor 1
  • Pregnancy