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Estrogen and Bisphenol A in Hypertension

Current Hypertension Reports volume 22, Article number: 23 (2020) Cite this article

Abstract

Purpose of Review

Cardiovascular disease (CVD) is a non-subsiding disease that remains a leading cause of morbidity and mortality. CVD has been associated with endocrine disruptors, such as bisphenol A (BPA). This review critically summarizes existing findings on BPA and hypertension, with particular attention to genomic, non-genomic, molecular, and cellular mechanisms of action that render BPA as a cardiovascular estrogenic disruptor.

Recent Findings

Owing to its similar estrogenic structure, BPA has been shown to affect various phenotypes that are regulated by the natural hormone, estrogen. Indeed, BPA has been shown to interact with estrogen receptors, located both in the cell membrane and in the cytoplasm/nucleus. Given that estrogen plays an important role in cardiovascular physiology, a contributing role for BPA in CVD would not be unexpected. Existing literature, though limited, established BPA as a source of disruption in cardiovascular health, particularly hypertension. However, effects of BPA are largely dependent on the dose, patient gender, tissue, and developmental stage of the exposed tissue/organ.

Summary

Accumulating evidence argues for an adverse effect of BPA on blood pressure, with this effect being gender, dose, and time specific. Thus, comprehensive studies which take these factors and other parameters, like epigenetic factors, into account are warranted before a thorough understanding is at hand.

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Funding

This publication was made possible by an MPP Fund (#320133) from the American University of Beirut-Faculty of Medicine to and a Farouk Jabre Research Award to Dr. Ali Eid.

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Authors and Affiliations

  1. Department of Biology, American University of Beirut, Beirut, Lebanon

    Zena Wehbe

  2. Department of Pharmacology and Therapeutics, Beirut Arab University, Beirut, Lebanon

    Suzanne A. Nasser

  3. Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Bliss Street, Riad El Solh, PO Box 11-0236, Beirut, 1107-2020, Lebanon

    Ahmed El-Yazbi & Ali H. Eid

  4. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

    Ahmed El-Yazbi

  5. Biology Department, Faculty of Sciences-Section I, Groupe Anti-cancer therapeutic approaches (ATAC), Laboratory Rammal Rammal, Lebanese University, Beirut, Lebanon

    Salam Nasreddine

  6. Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar

    Ali H. Eid

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  1. Zena Wehbe
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Wehbe, Z., Nasser, S.A., El-Yazbi, A. et al. Estrogen and Bisphenol A in Hypertension. Curr Hypertens Rep 22, 23 (2020). https://doi.org/10.1007/s11906-020-1022-z

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Keywords

  • Estrogen
  • Bisphenol A
  • Hypertension
  • Cardiovascular disease
  • Environmental pollution
  • Toxicology