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Dietary Protein: Mechanisms Influencing Hypertension and Renal Disease

  • Inflammation and Cardiovascular Diseases (A Kirabo, Section Editor)
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Abstract

Purpose of Review

This review will provide an in-depth coverage of the epidemiological and pre-clinical literature surrounding the role of dietary protein in hypertension, with a special emphasis on the history of our work on the Dahl salt-sensitive rat.

Recent Findings

Our studies have dedicated much effort into understanding the relationship between dietary protein and its effect on the development of salt-sensitive hypertension and renal injury. Our evidence over the last 15 years have demonstrated that both the source and amount of dietary protein can influence the severity of disease, where we have determined mechanisms related to immunity, the maternal environment during pregnancy, and more recently the gut microbiota, which significantly contribute to these diet-induced effects.

Summary

Deeper understanding of these dietary protein-related mechanisms may provide insight on the plausibility of dietary modifications as future therapeutic avenues for hypertension and renal disease.

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Acknowledgments

We kindly thank Dr. David Mattson for his continued support and guidance. We also acknowledge funding sources: 19CDA34660184.

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  1. Department of Physiology, Medical College of Georgia at Augusta University, 1120 15th Street, CA3145, Augusta, GA, 30912, USA

    John Henry Dasinger, Daniel J. Fehrenbach & Justine M. Abais-Battad

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Dasinger, J.H., Fehrenbach, D.J. & Abais-Battad, J.M. Dietary Protein: Mechanisms Influencing Hypertension and Renal Disease. Curr Hypertens Rep 22, 13 (2020). https://doi.org/10.1007/s11906-020-1018-8

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