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Effect of Garlic’s Active Constituents in Inflammation, Obesity and Cardiovascular Disease

Current Hypertension Reports volume 22, Article number: 6 (2020) Cite this article

Abstract

Purpose of Review

Several studies have attributed garlic’s beneficial properties to its high content of organosulfur compounds (OSCs). Here, we summarized recent studies published and some own findings regarding OSCs and its effects on cardiovascular disease, inflammation, and obesity.

Recent Finding

The analysis of the multiple actions produced by OSCs suggests that many of its bioactivities interfere against inflammation, oxidative stress, obesogenic effects, and mitochondrial dysfunction. Accumulating evidence from in vitro, animal, and human studies reinforce the notion that OSCs modify signaling pathways that trigger chronic diseases, and to highlight, actions over these pathways are related to the treatment of disorders addressed in this review.

Summary

Garlic’s bioactive OSCs behave like a nutraceutical panacea because they cover a broad spectrum of applications with promising impact for the prevention and treatment of prevalent chronic pathologies associated with low-grade inflammation.

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Funding

Authors received the following grants: from the Secretary of Science, Technology and Posgrade No. 06/J469 (to CC) and No. 06/J514 (to WM), Universidad Nacional de Cuyo, Mendoza Argentina; PIP-CONICET 2015-17 (to CC); PICT-2013-2379 (to AC) and PICT-2016-4541 (to WM).

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  1. CONICET Institute of Medicine and Experimental Biology of Cuyo (IMBECU), Mendoza, Argentina

    Isabel Quesada, Matilde de Paola, Walter Manucha & Claudia Castro

  2. Facultad de Ciencias Médicas. Mendoza, Universidad Nacional de Cuyo, Mendoza, Argentina

    Isabel Quesada, Matilde de Paola, Walter Manucha & Claudia Castro

  3. CONICET Agricultural Biology Institute of Mendoza (IBAM), Mendoza, Argentina

    Carolina Torres-Palazzolo & Alejandra Camargo

  4. Facultad de Ciencias Agrarias. Mendoza, Universidad Nacional de Cuyo, Mendoza, Argentina

    Carolina Torres-Palazzolo & Alejandra Camargo

  5. Department of Pediatrics, Nephrology Division, Miller School of Medicine, University of Miami, Miami, FL, USA

    León Ferder

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  1. Isabel Quesada
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  2. Matilde de Paola
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  3. Carolina Torres-Palazzolo
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  4. Alejandra Camargo
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  5. León Ferder
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  6. Walter Manucha
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  7. Claudia Castro
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Correspondence to Claudia Castro.

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This article is part of the Topical Collection on Hypertension and Obesity

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Quesada, I., de Paola, M., Torres-Palazzolo, C. et al. Effect of Garlic’s Active Constituents in Inflammation, Obesity and Cardiovascular Disease. Curr Hypertens Rep 22, 6 (2020). https://doi.org/10.1007/s11906-019-1009-9

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