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The Use of Risk Assessment Tools and Prognostic Scores in Managing Patients with Pulmonary Arterial Hypertension

  • Pulmonary Hypertension (J Klinger, Section Editor)
  • Published:
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Abstract

Purpose of Review

Pulmonary arterial hypertension (PAH) is a chronic, progressive, and incurable disease with significant morbidity and mortality. Despite increasingly available treatment options, PAH patients continue to experience disease progression and increased rates of hospitalizations due to right heart failure. Physician’s ability to comprehensively assess PAH patients, determine prognosis, and monitor disease progression and response to treatment remains critical in optimizing outcomes.

Recent Findings

Risk assessment in PAH should include a range of clinical, hemodynamic, and exercise parameters, performed in a serial fashion over the course of treatment. Approaches to risk assessment in PAH patients include the use of risk variables, scores, and equations that stratify the impact of both modifiable (e.g., 6-min walk distance, functional class, brain natriuretic peptide), and non-modifiable (e.g., age, gender, PAH etiology) risk factors. Such tools allow physicians to better determine prognosis, allocate treatment resources, and enhance the consistency of treatment approaches across providers.

Summary

Comprehensive and accurate risk prediction is essential to make individualized treatment decisions and optimizing outcomes in PAH.

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Authors and Affiliations

  1. Department of Cardiovascular Disease, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA, 15212, USA

    Manreet Kanwar, Amresh Raina & Raymond Benza

  2. Carnegie Mellon University, Pittsburgh, PA, USA

    Lisa Lohmueller

  3. University of Pittsburgh, Pittsburgh, PA, USA

    Jidapa Kraisangka

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  1. Manreet Kanwar
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  2. Amresh Raina
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  5. Raymond Benza
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Correspondence to Raymond Benza.

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Conflict of Interest

Dr. KANWAR reports grants from NIH and personal fees from Bayer Inc., outside the submitted work; Dr. Raina reports personal fees and non-financial support from Actelion, personal fees and non-financial support from United Therapeutics, personal fees from Bayer, non-financial support from Liquidia, and non-financial support from Bellerophon, outside the submitted work. Drs. Lohmueller, Kraisangka, and Benza declare no conflicts of interest relevant to this manuscript.

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Kanwar, M., Raina, A., Lohmueller, L. et al. The Use of Risk Assessment Tools and Prognostic Scores in Managing Patients with Pulmonary Arterial Hypertension. Curr Hypertens Rep 21, 45 (2019). https://doi.org/10.1007/s11906-019-0950-y

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