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Possible Breathing Influences on the Control of Arterial Pressure After Sino-aortic Denervation in Rats

  • Secondary Hypertension: Nervous System Mechanisms (M Wyss, Section Editor)
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Abstract

Purpose of Review

Surgical removal of the baroreceptor afferents [sino-aortic denervation (SAD)] leads to a lack of inhibitory feedback to sympathetic outflow, which in turn is expected to result in a large increase in mean arterial pressure (MAP). However, few days after surgery, the sympathetic nerve activity (SNA) and MAP of SAD rats return to a range similar to that observed in control rats. In this review, we present experimental evidence suggesting that breathing contributes to control of SNA and MAP following SAD.The purpose of this review was to discuss studies exploring SNA and MAP regulation in SAD rats, highlighting the possible role of breathing in the neural mechanisms of this modulation of SNA.

Recent Findings

Recent studies show that baroreceptor afferent stimulation or removal (SAD) results in changes in the respiratory pattern.

Summary

Changes in the neural respiratory network and in the respiratory pattern must be considered among mechanisms involved in the modulation of the MAP after SAD.

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Acknowledgements

The authors acknowledge the excellent technical contribution of Leni G.H. Bonagamba (in memoriam) with the experiments performed in the Laboratory of Autonomic and Respiratory Control.

Funding

Studies conducted in the Laboratory of Autonomic and Respiratory Control coordinated by Benedito H. Machado were supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP #2013/06077-5 and #2013/15195-1), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, #303512/2015-6).

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Authors and Affiliations

  1. Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirao Preto, SP, 14049-900, Brazil

    Mateus R. Amorim, George Miguel P. R. Souza & Benedito H. Machado

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  1. Mateus R. Amorim
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  2. George Miguel P. R. Souza
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  3. Benedito H. Machado
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Contributions

MRA: revised the literature, wrote the manuscript, organized the figures and revised the final version. GMPRS and BHM: wrote several sections of the manuscript, revised, and approved the final version.

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Correspondence to Benedito H. Machado.

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The authors declare no conflicts of interest relevant to this manuscript.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Secondary Hypertension: Nervous System Mechanisms

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Amorim, M.R., Souza, G.M.P.R. & Machado, B.H. Possible Breathing Influences on the Control of Arterial Pressure After Sino-aortic Denervation in Rats. Curr Hypertens Rep 20, 2 (2018). https://doi.org/10.1007/s11906-018-0800-3

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  • DOI: https://doi.org/10.1007/s11906-018-0800-3

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