Abstract
Considered a global health crisis by the World Health Organization, hypertension (HTN) is the leading risk factor for death and disability. The majority of treated patients do not attain evidence-based clinical targets, which increases the risk of potentially fatal complications. HTN is the most common chronic condition seen in primary care; thus, implementing therapies that lower and maintain BP to within-target ranges is of tremendous public health importance. Isometric handgrip (IHG) training is a simple intervention endorsed by the American Heart Association as a potential adjuvant BP-lowering treatment. With larger reductions noted in HTN patients, IHG training may be especially beneficial for those who (a) have difficulties continuing or increasing drug-based treatment; (b) are unable to attain BP control despite optimal treatment; (c) have pre-HTN or low-risk stage I mild HTN; and (d) wish to avoid medications or have less pill burden. IHG training is not routinely prescribed in clinical practice. To shift this paradigm, we focus on (1) the challenges of current HTN management strategies; (2) the effect of IHG training; (3) IHG prescription; (4) characterizing the population for whom it works best; (5) clinical relevance; and (6) important next steps to foster broader implementation by clinical practitioners.
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Pescatello L, Franklin B, Fagard R, Farquhar W, Kelley GA, Ray CA. Exercise and hypertension. Med Sci Sports Exerc. 2004;36:533–53.
Joffres M, Falaschetti E, Gillespie C, Robitaille C, Loustalot F, Poulter N, McAlister F, Johansen H, Baclic O, Campbell N. Hypertension prevalence, awareness, treatment and control in national surveys from England, the USA and Canada, and correlation with stroke and ischaemic heart disease mortality: a cross-sectional study. BMJ Open. 2013;3 doi:10.1136/bmjopen-2013-003423.
Danaei G, Ding E, Mozaffarian D, Taylor B, Rehm J, Murray C, Ezzati M. The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors. PLoS Med. 2009;6:e1000058.
•• Benjamin E, Blaha M, Chiuve S, Cushman M, Das S, Deo R, de Ferranti S, Floyd J, Fornage M, Gillespie C, Isasi C. Heart disease and stroke statistics - 2017 update: a report from the American Heart Association. Circulation. 2017;135:e146–603. This report highlights the growing burden of hypertension, and emphasizes the importance of effective blood pressure control.
Ezzati M, Lopez A, Rodgers A, Vander Hoorn S, Murray C. Selected major risk factors and global and regional burden of disease. Lancet. 2002;360:1347–60.
World Health Organization. A global brief on hypertension. Silent killer, global health crisis. WHO Press 2013. World Health Day; 2013.
Forouzanfar M, Liu P, Roth G, Ng M, Biryukov S, Marczak L, Alexander L, Estep K, Abate K, Akinyemiju T. Global burden of hypertension and systolic blood pressure of at least 110 to 115 mm Hg, 1990-2015. JAMA. 2017;317:165–82.
Lim S, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, MA AM, Amann M, Anderson HR, Andrews KG, Aryee M, Atkinson C, Bacchus LJ, Bahalim AN, Balakrishnan K, Balmes J, Barker-Collo S, Baxter A, Bell ML, Blore JD, Blyth F, Bonner C, Borges G, Bourne R, Boussinesq M, Brauer M, Brooks P, Bruce NG, Brunekreef B, Bryan-Hancock C, Bucello C, Buchbinder R, Bull F, Burnett RT, Byers TE, Calabria B, Carapetis J, Carnahan E, Chafe Z, Charlson F, Chen H, Chen JS, Cheng AT-A, Child JC, Cohen A, Colson KE, Cowie BC, Darby S, Darling S, Davis A, Degenhardt L, Dentener F, Des Jarlais DC, Devries K, Dherani M, Ding EL, Dorsey ER, Driscoll T, Edmond K, Ali SE, Engell RE, Erwin PJ, Fahimi S, Falder G, Farzadfar F, Ferrari A, Finucane MM, Flaxman S, Fowkes FG, Freedman G, Freeman MK, Gakidou E, Ghosh S, Giovannucci E, Gmel G, Graham K, Grainger R, Grant B, Gunnell D, Gutierrez HR, Hall W, Hoek HW, Hogan A, Hosgood HD III, Hoy D, Hu H, Hubbell BJ, Hutchings SJ, Ibeanusi SE, Jacklyn GL, Jasrasaria R, Jonas JB, Kan H, Kanis JA, Kassebaum N, Kawakami N, Khang YH, Khatibzadeh S, Khoo JP, Kok C, Laden F, Lalloo R, Lan Q, Lathlean T, Leasher JL, Leigh J, Li Y, Lin JK, Lipshultz SE, London S, Lozano R, Lu Y, Mak J, Malekzadeh R, Mallinger L, Marcenes W, March L, Marks R, Martin R, Mc Gale P, McGrath J, Mehta S, Memish ZA, Mensah GA, Merriman TR, Micha R, Michaud C, Mishra V, Hanafiah KM, Mokdad AA, Morawska L, Mozaffarian D, Murphy T, Naghavi M, Neal B, Nelson PK, Nolla JM, Norman R, Olives C, Omer SB, Orchard J, Osborne R, Ostro B, Page A, Pandey KD, Parry CD, Passmore E, Patra J, Pearce N, Pelizzari PM, Petzold M, Phillips MR, Pope D, Pope CA III, Powles J, Rao M, Razavi H, Rehfuess EA, Rehm JT, Ritz B, Rivara FP, Roberts T, Robinson C, Rodriguez-Portales JA, Romieu I, Room R, Rosenfeld LC, Roy A, Rushton L, Salomon JA, Sampson U, Sanchez-Riera L, Sanman E, Sapkota A, Seedat S, Shi P, Shield K, Shivakoti R, Singh GM, Sleet DA, Smith E, Smith KR, Stapelberg NJ, Steenland K, Stöckl H, Stovner LJ, Straif K, Straney L, Thurston GD, Tran JH, Van Dingenen R, van Donkelaar A, Veerman JL, Vijayakumar L, Weintraub R, Weissman MM, White RA, Whiteford H, Wiersma ST, Wilkinson JD, Williams HC, Williams W, Wilson N, Woolf AD, Yip P, Zielinski JM, Lopez AD, Murray CJ, Ezzati M. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2224–60.
Hemmelgarn B, Chen G, Walker R, McAlister F, Quan H, Tu K, Khan N, Campbell N. Trends in antihypertensive drug prescriptions and physician visits in Canada between 1996 and 2006. Can J Cardiol. 2008;24:507–12.
James P, Oparil S, Carter B. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth joint national committee (JNC 8). JAMA. 2014;311:507–20.
Centers for Disease Control and Prevention. National Ambulatory Medical Care Survey: 2013 State and National Summary Tables; 2017.
Chobanian A, Bakris G, Black H, Cushman W, Green L, Izzo J Jr, Jones D, Materson B, Oparil S, Wright JT Jr, Roccella E. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;42:1206–52.
Sarafidis P. Epidemiology of resistant hypertension. J Clin Hypertens. 2011;13:523–8.
Wilkins K, Campbell N, Joffres M, McAlister F, Nichol M, Quach S, Johansen H, Tremblay M. Blood pressure in Canadian adults. Stats Can Health Reports. 2010;21:37–46.
Wolf-Maier K, Cooper R, Banegas J, Giampaoli S, Hense H, Joffres M, Kastarinen M, Poulter N, Primatesta P, Rodriguez-Artalejo F. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA. 2003;289:2363–9.
•• Mills K, Bundy J, Kelly TN, Reed J, Kearney P, Reynolds K, Chen J, He J. Global burden of hypertension: analysis of population-based studies from 89 countries. J Hypertens. 2015:33. This analysis highlights the global burden of hypertension.
Petrella R, Merikle E, Jones J. Prevalence, treatment, and control of hypertension in primary care: gaps, trends, and opportunities. J Clin Hypertens. 2007;9:28–35.
Campbell N, Bovet P, Schutte A, Lemogoum D, Nkwescheu A. High blood pressure in sub-Saharan Africa: why prevention, detection, and control are urgent and important. J Clin Hypertens. 2015;17:663–7.
Ghofrani H, Weaver F, Nadim M. Resistant hypertension. Medical management and alternative therapies. Cardiol Clin. 2015;33:75–87.
Schiffrin E. Remodeling of resistance arteries in essential hypertension and effects of antihypertensive treatment. Am J Hypertens. 2004;17:1192–200.
Ferroni P, Basili S, Paoletti V, Davi G. Endothelial dysfunction and oxidative stress in arterial hypertension. Nutr Metab Cardiovasc Dis. 2006;16:222–33.
Yamada Y, Miyajima E, Tochikubo O, Matsukawa T, Ishii M. Age-related changes in muscle sympathetic nerve activity in essential hypertension. Hypertension. 1989;13:870–7.
Anderson E, Sinkey C, Lawton W, Mark A. Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings. Hypertension. 1989;14:177–83.
Fujita M, Ando K, Nagae A, Fujita T. Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in salt sensitive hypertension. Hypertension. 2007;50:360–7.
Nozoe M, Hirooka Y, Koga Y, Sagara Y, Kishi T, Engelhardt JF, Sunagawa K. Inhibition of Rac1-derived reactive oxygen species in nucleus tractus solitarius decreases blood pressure and heart rate in stroke-prone spontaneously hypertensive rats. Hypertension. 2007;50:62–8.
Biaggioni I. Sympathetic control of the circulation in hypertension: lessons from autonomic disorders. Curr Opin Nephrol Hypertens. 2003;12:175–80.
Boos CJ, Lip GY. Is hypertension an inflammatory process? Curr Pharm Des. 2006;12:1623–35.
Lassegue B, Griendling KK. Reactive oxygen species in hypertension. An update Am J Hypertens. 2004;17:852–60.
Faulx M, Wright A, Hoit B. Detection of endothelial dysfunction with brachial artery ultrasound scanning. Am Heart J. 2003;145:943–51.
Braunwald E, Zipes D, Libby P. Heart Disease. A textbook of cardiovascular disease medicine. ed 6th, USA, W.B. Saunders Company, 2007.
Leite-Moreira AF. Current perspectives in diastolic dysfunction and diastolic heart failure. Heart. 2006;92:712–8.
Taylor C, Tillin T, Chaturvedi N, Dewey M, Ferri C, Hughes A, Prince M, Richards M, Shah A, Stewart R. Midlife hypertensive status and cognitive function 20 years later: the Southall and Brent revisited study. J Am Geriatr Soc. 2013;61:1489–98.
Wysocki M, Luo X, Schmeidler J, Dahlman K, Lesser G, Grossman H, Haroutunian V, Beeri M. Hypertension is associated with cognitive decline in elderly people at high risk for dementia. Am J Geriatr Psychiatry. 2012;20:179–87.
Battersby C, Hartley K, Fletcher A, Markowe H, Styles W, Sapper H, Bulpitt C. Quality of life in treated hypertension: a case-control community based study. J Hum Hypertens. 1995;9:981–6.
World Health Organization. 2008–2013 Action plan for the global strategy for the prevention and control of noncommunicable diseases. WHO Media; 2008;1–42.
World Health Organization. World report on aging and health. WHO Media; 2015;1–260.
Arguedas J, Perez M, Wright J. Treatment blood pressure targets for hypertension. Cochrane Database of Syst Rev. 2009;4:CD004349.
• Leung A, Nerenberg K, Daskalopoulou S, McBrien K, Zarnke K, Dasgupta K, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Tremblay G, McLean D, Tobe S, Ruzicka M, Burns K, Vallee M, Prasad G, Lebel M, Feldman R, Selby P, Pipe A, Schiffrin E, McFarlane P, Oh P, Hegele R, Khara M, Wilson T, Penner S, Burgess E, Herman R, Bacon S, Rabkin S, Gilbert R, Campbell T, Grover S, Honos G, Lindsay P, Hill M, Coutts S, Gubitz G, Campbell N, Moe G, Howlett J, Boulanger J, Prebtani A, Larochelle P, Leiter L, Jones C, Ogilvie R, Woo V, Kaczorowski J, Trudeau L, Petrella R, Hiremath S, Drouin D, Lavoie K, Hamet P, Fodor G, Gregoire J, Lewanczuk R, Dresser G, Sharma M, Reid D, Lear S, Moullec G, Gupta M, Magee L, Logan A, Harris K, Dionne J, Fournier A, Benoit G, Feber J, Poirier L, Padwal R, Rabi D. Hypertension Canada’s 2016 Canadian Hypertension Education Program guidelines for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension. Can J Cardiol. 2016;32:569–88. The Canadian Hypertension Education Program is one of the few organizations that note handgrip training as a form of adjuvant resistance exercise.
National Heart Lung and Blood Institute. Landmark NIH study shows intensive blood pressure management may save lives. http://www.nhlbi.nih.gov/news/press-releases/2015/landmark-nih-study-shows-intensive-blood-pressure-management-may-save-lives; 2015.
The SPRINT Research Group. A randomized trial of intensive versus standard blood-pressure control. New Engl J Med. 2015;373:2103–16.
Yusuf S, Lonn E, Pais P. HOPE-3 investigators. Blood-pressure and cholesterol lowering in persons without cardiovascular disease. New Engl J Med. 2016; doi:10.1056/NEJMoa1600177.
Flack J, Sica D, Bakris G, Brown A, Ferdinand K, Grimm R, Hall W, Jones W, Kountz D, Lea J, Nasser S, Nesbitt S, Saunders E, Scisney-Matlock M, Jamerson K, on behalf of the International Society on Hypertension in Blacks. Management of high blood pressure in blacks: an update of the International Society on Hypertension in Blacks consensus statement. Hypertension. 2010;56:780–800.
Myers M, Kaczorowski J, Paterson J, Dolovich L, Tu K. Thresholds for diagnosing hypertension based on automated office blood pressure measurements and cardiovascular risk. Hypertension. 2015;66:489–95.
Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A. 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Blood Press. 2013;22:193–278.
Weber M, Schiffrin E, White W, Mann S, Lindholm L, Kenerson J, Flack J, Carter B, Materson B, Ram C, Cohen D, Cadet J, Jean-Charles R, Taler S, Kountz D, Townsend R, Chalmers J, Ramirez A, Bakris G, Wang J, Schutte A, Bisognano J, Touyz R, Sica D, Harrap S. Clinical practice guidelines for the management of hypertension in the community. J Clin Hypertens. 2014;16:14–26.
Pescatello L, MacDonald H, Ash G, Lamberti L, Farquhar W, Arena R, Johnson B. Assessing the existing professional exercise recommendations for hypertension: a review and recommendations for future research priorities. Mayo Clin Proc. 2015;90:801–12.
•• Brook R, Appel L, Rubenfire M, Ogedegbe G, Bisognano J, Elliott W, Fuchs F, Hughes J, Lackland D, Staffileno B, Townsend R, Rajagopalan S. Beyond medications and diet: alternative approaches to lowering blood pressure. A scientific statement from the American Heart Association. Hypertension. 2013;61:1360–83. This statement highlights the challenges associated with current hypertension management, and provides support for isometric handgrip training as a promising adjuvant intervention, and one that is amenable for use in clinical practice.
Sabate E. Adherence to long-term therapies: evidence for action. World Health Organization, 2003.
Rajpura J, Nayak R. Medication adherence in a sample of elderly suffering from hypertension: evaluating the influence of illness perceptions, treatment beliefs, and illness burden. J Manage Care Pharm. 2014;20:58–65.
Hyre A, Krousel-Wood M, Muntner P, Kawasaki L, DeSalvo K. Prevalence and predictors of poor antihypertensive medication adherence in an urban health clinic setting. J Clin Hypertens. 2007;9:179–86.
Liao Y, Bang D, Cosgrove S, Dulin R, Harris Z, Stewart A, Taylor A, White S, Yatabe G, Liburd L, Giles W. Surveillance of health status in minority communities—racial and ethnic approaches to community health across the U.S. (REACH U.S.). Risk Factor Survey, United States, 2009. Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion 2011; Surveillance Summaries: 60(SS06).
Bethancourt H, Rosenberg D, Beatty T, Arterburn D. Barriers to and facilitators of physical activity program use among older adults. Clin Med & Res. 2014;12:10–20.
Franco M, Tong A, Howard K, Sherrington C, Ferreira P, Pinto R, Ferreira M. Older people’s perspectives on participation in physical activity: a systematic review and thematic synthesis of qualitative literature. Br J Sports Med. 2015; doi:10.1136/bjsports-2014-094015.
Jefferis B, Sartini C, Lee I, Choi M, Amuzu A, Gutierrez C, Casas J, Ash S, Lennnon L, Wannamethee S. Adherence to physical activity guidelines in older adults, using objectively measured physical activity in a population-based study. BMC Pub Health. 2014;14:2–9.
Pekmezi D, Barbera B, Bodenlos J, Jones G, Brantley P. Promoting physical activity in low income African Americans: project LAPS. J Health Dispar Res Pract. 2009;3:82–91.
Richter DL, Wilcox S, Greaney M, Henderson K, Ainsworth B. Environmental, policy, and cultural factors related to physical activity in African American women. Women & Health. 2002;36:89–107.
Walcott-McQuigg J, Prohaska T. Factors influencing participation of African American elders in exercise behavior. Public Health Nurs. 2001;18:194–203.
Henderson K, Ainsworth B. A synthesis of perceptions about physical activity among older African American and American Indian women. Am J Public Health. 2003;93:313–7.
•• Inder J, Carlson D, Dieberg G, McFarlane J, Hess N, Smart N. Isometric exercise training for blood pressure management: a systematic review and meta-analysis to optimize benefit. Hypertens Res. 2016;39:88–94. This is the most recent meta-analysis of randomized controlled trials citing the benefits of isometric handgrip training.
Boggia J, Thijs L, Hansen T, Li Y, Kikuya M, Bjorklund-Bodegard K, Richart T, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Olszanecka A, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Maestre G, Sandoya E, Kawecka-Jaszcz K, Imai Y, Wang J, Ibsen H, O’Brien E, Staessen J, on behalf of the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) Investigators. Ambulatory blood pressure monitoring in 9357 subjects from 11 populations highlights missed opportunities for cardiovascular prevention in women. Hypertension. 2011;57:397–405.
Fagard R, Celis H, Lutgarde T, Staessen J, Clement D, De Buyzere M, De Bacquer D. Daytime and nighttime blood pressure as predictors of death and cause-specific cardiovascular events in hypertension. Hypertension. 2008;51:55–61.
Pickering T, Shimbo D, Haas D. Ambulatory blood pressure monitoring. New Engl J Med. 2006;354:2368–74.
Sarafidis P, Bakris G. Resistant hypertension: an overview of evaluation and treatment. J Am Coll Cardiol. 2008;52:1749–57.
Somani Y, Baross A, Levy P, Zinszer K, Milne K, Swaine I, McGowan C. Reductions in ambulatory blood pressure in young normotensive men and women after isometric resistance training and its relationship with cardiovascular reactivity. Blood Press Monit. 2017;22:1–7.
Stiller-Moldovan C, Kenno K, McGowan C. Effects of isometric handgrip training on blood pressure (resting and 24 h ambulatory) and heart rate variability in medicated hypertensive patients. Blood Press Monit. 2012;17:55–61.
Badrov M, Bartol C, Dibartolomeo M, Millar P, McNevin N, McGowan C. Effects of isometric handgrip training dose on resting blood pressure and resistance vessel endothelial function in normotensive women. Eur J Appl Physiol. 2013;113:2091–100.
Badrov M, Horton S, Millar P, McGowan C. Cardiovascular stress reactivity tasks successfully predict the hypotensive response of isometric handgrip training in hypertensives. Psychophysiology. 2013;50:407–14.
McGowan C, Visocchi A, Faulkner M, Verduyn R, Rakobowchuk M, Levy AS, McCartney N, MacDonald M. Isometric handgrip training improves local flow-mediated dilation in medicated hypertensives. Eur J Appl Physiol. 2007;99:227–34.
McGowan C, Levy A, McCartney N, MacDonald M. Isometric handgrip training does not improve flow-mediated dilation in persons with normal blood pressure. Clin Sci. 2007;12:403–9.
Millar P, Bray S, MacDonald M, McCartney N. The hypotensive effect of isometric handgrip training using an inexpensive spring handgrip training device. J Cardiopulm Rehabil Prev. 2008;28:203–7.
Millar P, Levy A, McGowan C, McCartney N, MacDonald M. Isometric handgrip training lowers blood pressure and increases heart rate complexity in medicated hypertensive patients. Scand J Med Sci Sports. 2013;23:620–6.
Ray C, Carrasco D. Isometric handgrip training reduces arterial pressure at rest without changes in sympathetic nerve activity. Am J Phys. 2000;279:H245–9.
Taylor A, McCartney N, Kamath M, Wiley R. Isometric training lowers resting blood pressure and modulates autonomic control. Med Sci Sports Exerc. 2003;35:251–6.
Hanik S, Badrov M, Stiller-Moldovan C, DiBartolomeo M, Millar P, Clarke D, McNevin N, McGowan C. Isometric handgrip training induces equal blood pressure reductions in normotensive males and females without influencing heart rate variability. Can J Cardiol. 2012;28:S118–9.
Wiley R, Dunn C, Cox R, Hueppchen A, Scott M. Isometric exercise training lowers resting blood pressure. Med Sci Sports Exerc. 1992;24:749–54.
Hanik S, Somani Y, Baross A, Swaine I, Milne K, McGowan C. The mechanism underlying the hypotensive effect of isometric handgrip training: is it cardiac output mediated? Appl Physiol Nutr Metab. 2014;39:S21.
Somani Y, Hanik S, Malandruccalo A, Freeman S, Caruana N, Badrov M, Baross A, Swaine I, Milne K, McGowan C. Isometric handgrip (IHG) training-induced reductions in resting blood pressure: reactivity to a 2-minute handgrip task identifies responders and non-responders in young normotensive individuals (LB661). FASEB J. 2014;28:LB661.
Somani Y, Hanik S, Badrov M, Baross A, Swaine I, Milne K, McGowan C. Can blood pressure reactivity to a 2-minute isometric handgrip task predict reductions in ambulatory blood pressure? Appl Physiol Nutr Metab. 2014;39:S43.
Badov M, Freeman S, Zokvic M, Millar P, McGowan C. Isometric exercise training lowers resting blood pressure and improves local brachial artery flow-mediated dilation equally in men and women. Eur J Appl Physiol. 2016;116:1289–96.
• Millar P, McGowan C, Cornelissen V, Araujo C, Swaine I. Evidence for the role of isometric exercise training in reducing blood pressure: potential mechanisms and future directions. Sports Med. 2014;44:345–56. This review provides a nice overview of the hypothesized mechanisms for isometric handgrip training-induced blood pressure-lowering.
Millar P, Bray S, McGowan C, MacDonald M, McCartney N. Effects of isometric handgrip training among people medicated for hypertension: a multilevel analysis. Blood Press Monit. 2007;12:307–14.
Peters P, Alessio H, Hagerman A, Ashton T, Nagy S, Wiley R. Short-term isometric exercise reduces systolic blood pressure in hypertensive adults: possible role of reactive oxygen species. Int J Cardiol. 2006;110:199–205.
Owen A, Wiles J, Swaine I. Effect of isometric exercise on resting blood pressure: a meta analysis. J Hum Hypertens. 2010;24:796–800.
Carlson D, Dieberg G, Hess N, Millar P, Smart N. Isometric exercise training for blood pressure management: a systematic review and meta-analysis. Mayo Clin Proc. 2014;89:327–34.
McGowan C, Levy A, Millar P, Guzman J, Morillo C, McCartney N, MacDonald M. Acute vascular responses to isometric handgrip exercise and effects of training in persons medicated for hypertension. Am J Physiol Heart Circ Physiol. 2006;291:1797–802.
Millar P, MacDonald M, Bray S, McCartney N. Isometric handgrip exercise improves acute neurocardiac regulation. Eur J Appl Physiol. 2009;107:509–15.
Araujo C, Duarte C, Gonzalves F, Medeiros H, Lemos F, Gouvvea A. Hemodynamic responses to an isometric handgrip training protocol. Arq Bras Cardiol. 2011;97:413–9.
•• Carlson D, McFarlane J, Dieberg G, Smart N. Rate pressure product responses during an acute session of isometric resistance training: a randomized trial. J Hypertens Cardiol. 2017;2:1–11. This is the first isometric handgrip study that directly addresses the “safety” of isometric handgrip exercise.
Badrov M, Millar P, McGowan C. Role of isometric handgrip training in the management of hypertension: insights from cardiovascular stress reactivity testing. Crit Revs Phys Rehabil Med. 2010;22:13–28.
Millar P, Bray S, MacDonald M, McCartney N. Cardiovascular reactivity to psychophysiological stressors: association with hypotensive effects of isometric handgrip training. Blood Press Monit. 2009;14:190–5.
Berenson G, Chen W, DasMahapatra P, Fernandez C, Giles T, Xu J, Srinivasan S. Stimulus response of blood pressure in black and white young individuals helps explain racial divergence in adult cardiovascular disease: the Bogalusa Heart Study. J Am Soc Hypertens. 2011;5:230–8.
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McGowan, C.L., Proctor, D.N., Swaine, I. et al. Isometric Handgrip as an Adjunct for Blood Pressure Control: a Primer for Clinicians. Curr Hypertens Rep 19, 51 (2017). https://doi.org/10.1007/s11906-017-0748-8
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DOI: https://doi.org/10.1007/s11906-017-0748-8