Abstract
Oxidative stress plays a pivotal role in various pathological conditions, including hypertension, pulmonary hypertension, diabetes, and chronic kidney disease, with high levels of oxidative stress in target organs such as the heart, pancreas, kidney, and lung. Oxidative stress is known to activate multiple intracellular signaling, which induces apoptosis or cell overgrowth, leading to organ dysfunction. As such, targeting oxidative stress is thought to be effective in protecting against organ damage, and measuring oxidative stress status may serve as a biomarker in diverse disease states. Several new intrinsic anti-oxidative or pro-oxidative factors have recently been reported, and are potential new targets. In the present review, we focus on diabetes, pulmonary hypertension, and renal dysfunction, and their relation with new targets – adrenomedullin, oxidized LDL, and mineralocorticoid receptor.
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This work was supported by JSPS KAKENHI Grant Number 24790863, 26461262.
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Conflict of Interest Sayoko Ogura has received a JSPS KAKENHI Grant Number 24790863, 26461262.
Tatsuo Shimosawa has received an honorarium payment from Takeda Pharmaceutical Co., Ltd.
Human and Animal Rights and Informed Consent This article does not contain any studies with human or animal subjects performed by any of the authors.
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This article is part of the Topical Collection on Mediators, Mechanisms, and Pathways in Tissue Injury
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Ogura, S., Shimosawa, T. Oxidative Stress and Organ Damages. Curr Hypertens Rep 16, 452 (2014). https://doi.org/10.1007/s11906-014-0452-x
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DOI: https://doi.org/10.1007/s11906-014-0452-x