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Establishing Targets for Hypertension Control in Patients with Comorbidities

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Abstract

Most current guidelines recommend tighter blood pressure (BP) control in hypertensive patients with comorbidities. These recommendations are based on epidemiologic data indicating that cardiovascular risk increases at lower BP levels in hypertensive patients with comorbidities than in those without comorbidities. Hypertension guidelines usually reflect outcomes from previous studies, but current recommendations for patients with comorbidities have preceded the evidence. We review recent studies investigating whether these new targets can be achieved, whether they are well tolerated, and whether they positively affect the outcomes. The results of the few current studies about outcomes in lower BP target groups are either negative or somewhat—but not decidedly—positive. There is a need for new trials designed to evaluate the validity of current recommendations for tighter BP control in hypertensive patients with comorbidities. Additionally, existing data from published trials could be reanalyzed to provide further clarification.

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Authors and Affiliations

  1. University of Michigan, 2368 Cardiovascular Center, 1500 East Medical Center Drive, SPC 5853, Ann Arbor, MI, 48109, USA

    Stevo Julius

  2. Hypertension Program, Hospital de Clinicas J. de San Martin, University of Buenos Aires School of Medicine, Buenos Aires, Argentina

    Carlos Feldstein

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  1. Carlos Feldstein
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Correspondence to Stevo Julius.

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Feldstein, C., Julius, S. Establishing Targets for Hypertension Control in Patients with Comorbidities. Curr Hypertens Rep 12, 465–473 (2010). https://doi.org/10.1007/s11906-010-0153-z

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