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Perioperative control of hypertension: When will it adversely affect perioperative outcome?

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Abstract

Much has been published about the impact of treatment on adverse outcomes in patients with cardiovascular diseases. Hypertension is an extremely common condition affecting a significant percentage of the world population. Although care guidelines exist for the medical patient with raised blood pressure, there are no accepted guidelines for the preoperative evaluation and perioperative care of the patient with hypertension who undergoes noncardiac surgery. Of particular importance are defining at-risk groups of patients, and the indications for cancellation to treat and hence reduce this risk. This review examines the interactions between hypertension, drug therapies, anesthesia, and adverse outcomes in these patients. Recommendations for identifying patients at greatest risk of adverse cardiovascular events and cardiac mortality have been developed through evaluation of available data. Based on these findings, the only patients in whom cancellation may be justified and the level of hypertension treated prior to surgery are those with stage 2 hypertension and accompanying target-organ damage, or stage 3 hypertension (blood pressure > 180/> 110 mm Hg).

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References and Recommended Reading

  1. Aksnes TA, Kjeldsen SE, Rostrup M, et al.: Impact of new-onset diabetes mellitus on cardiac outcomes in the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial population. Hypertension 2007, 50:467–473.

    Article  PubMed  CAS  Google Scholar 

  2. Dahlof B, Sever PS, Poulter NR, et al.: Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required in the Anglo-Scandinavian Outcome Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005, 366:895–906.

    Article  PubMed  CAS  Google Scholar 

  3. Williams B, Lacy PS, Thom SM, et al.: Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 2006, 113:1213–1225.

    Article  PubMed  CAS  Google Scholar 

  4. Pepine CJ, Handberg EM, Cooper-DeHoff RM, et al.: A calcium antagonist vs. a non calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil SR-Trandolapril Study (INVEST). Psychosom Med 2005, 67:398–406.

    Article  PubMed  CAS  Google Scholar 

  5. Coriat P, Richer C, Douraki T, et al.: Influence of chronic angiotensin-converting enzyme inhibition on anesthetic induction. Anesthesiology 1994, 81:299–307.

    Article  PubMed  CAS  Google Scholar 

  6. Brabant SM, Bertrand M, Eyraud D, et al.: The hemodynamic effects of anesthetic induction in vascular surgical patients chronically treated with angiotensin II receptor antagonists. Anesth Analg 1999, 89:1388–1392.

    Article  PubMed  CAS  Google Scholar 

  7. Bertrand M, Godel G, Meersschaert K, et al.: Should the angiotensin II antagonists be discontinued before surgery? Anesth Analg 2001, 92:26–30.

    Article  PubMed  CAS  Google Scholar 

  8. Pigott DW, Nagle C, Allman K, et al.: Effect of omitting regular ACE inhibitor medication before cardiac surgery on haemodynamic variables and vasoactive drug requirements. Br J Anaesth 1999, 83:715–720.

    PubMed  CAS  Google Scholar 

  9. Wallace AW, Galindez D, Salahieh A, et al.: Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery. Anesthesiology 2004, 101:284–293.

    Article  PubMed  CAS  Google Scholar 

  10. Wijeysundera DN, Naik JS, Beattie WS: Alpha-2 adrenergic agonis to prevent perioperative cardiovascular complications: a meta-analysis. Am J Med 2003, 114:742–752.

    Article  PubMed  CAS  Google Scholar 

  11. Biccard BM, Goga S, de Beurs J: Dexmedetomidine and cardiac protection for non-cardiac surgery: a meta-analysis of randomised controlled trials. Anaesthesia 2008, 63:4–14.

    Article  PubMed  CAS  Google Scholar 

  12. Sear JW, Jewkes C, Tellez J-C, Foex P: Does the choice of antihypertensive therapy influence haemodynamic response to induction, laryngoscopy and intubation. Br J Anaesth 1994, 73:303–308.

    Article  PubMed  CAS  Google Scholar 

  13. Stone JG, Foex P, Sear JW, et al.: Myocardial ischemia in untreated hypertensive patients: effect of a single small oral dose of a beta-adrenergic blocking agent. Anesthesiology 1988, 68:495–500.

    Article  PubMed  CAS  Google Scholar 

  14. Kadoi Y, Saito S, Takahashi K: The comparative effects of sevoflurane vs isoflurane on cerebrovascular carbon dioxide reactivity in patients with hypertension. Acta Anaesthesiol Scand 2007, 51:1382–1387.

    PubMed  CAS  Google Scholar 

  15. Wallace A, Layug B, Tateo I, et al.: Prophylactic atenolol reduces postoperative myocardial ischemia. Anesthesiology 1998, 88:7–17.

    Article  PubMed  CAS  Google Scholar 

  16. Mangano DT, Layug EL, Wallace A, Tateo I: Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. Multicenter Study of Perioperative Ischemia Research Group. New Engl J Med 1996, 335:1713–1720.

    Article  PubMed  CAS  Google Scholar 

  17. Poldermans D, Boersma E, Bax JJ, et al.: The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group. New Engl J Med 1999, 341:1789–1794.

    Article  PubMed  CAS  Google Scholar 

  18. Fleisher LA, Beckman JA, Brown KA, et al.: AAC/AHA 2007 Guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to update the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Circulation 2007, 116:1971–1996.

    Article  PubMed  Google Scholar 

  19. POISE study group, Devereaux PJ, Yang H, et al.: Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet 2008, 371:1839–1847.

    Article  PubMed  CAS  Google Scholar 

  20. Yang H, Raymer K, Butler R, et al.: The effects of perioperative beta-blockade: results of the metoprolol after vascular surgery (MaVS) study, a randomized controlled trial. Am Heart J 2006, 152:983–990.

    Article  PubMed  CAS  Google Scholar 

  21. Brady AR, Gibbs JS, Greenhalgh RM, et al.: POBBLE trial investigators: Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: results of a randomized double-blind controlled trial. J Vasc Surg 2005, 41:602–609.

    Article  PubMed  CAS  Google Scholar 

  22. Sprague HB: The heart in surgery. An analysis of the results of surgery on cardiac patients during the past ten years at the Massachusetts General Hospital. Surg Gynecol Obst 1929, 49:54–58.

    Google Scholar 

  23. Prys-Roberts C, Meloche R, Foex P: Studies of anaesthesia in relation to hypertension. I. Cardiovascular responses of treated and untreated patients. Br J Anaesth 1971, 43:122–137.

    Article  PubMed  CAS  Google Scholar 

  24. Prys-Roberts C, Greene LT, Meloche R, Foex P: Studies of anaesthesia in relation to hypertension. II. Haemodynamic consequences of induction and endotracheal intubation. Br J Anaesth 1971, 43:531–547.

    Article  PubMed  CAS  Google Scholar 

  25. Prys-Roberts C, Foex P, Biro GP, Roberts JG: Studies of anaesthesia in relation to hypertension. V. Adrenergic beta-receptor blockade. Br J Anaesth 1973, 45:671–681.

    Article  PubMed  CAS  Google Scholar 

  26. Goldman L, Caldera DL: Risks of general anesthesia and elective operation in the hypertensive patient. Anesthesiology 1979, 50:285–292.

    Article  PubMed  CAS  Google Scholar 

  27. Forrest JB, Rehder K, Cahalan MK, Goldsmith CH: Multicenter Study of General Anesthesia. III: Predictors of severe perioperative adverse outcomes. Anesthesiology 1992, 76:3–15.

    Article  PubMed  CAS  Google Scholar 

  28. Davenport DL, Ferraris VA, Hosokawa P, et al.: Multivariable predictors of postoperative cardiac adverse events after general and vascular surgery: results from the Patient Safety in Surgery study. J Am Coll Surg 2007, 204:1199–1210.

    Article  PubMed  Google Scholar 

  29. Muir AD, Reeder MK, Foex P, et al.: Preoperative silent myocardial ischaemia: incidence and predictors in a general surgical population. Br J Anaesth 1991, 67:373–377.

    Article  PubMed  CAS  Google Scholar 

  30. Allman KG, Muir A, Howell SJ, et al.: Resistant hypertension and pre-operative silent myocardial ischaemia in surgical patients. Br J Anaesth 1994, 73:574–578.

    Article  PubMed  CAS  Google Scholar 

  31. Browner WS, Li J, Mangano DT; Study of Perioperative Ischemia Research Group: In-hospital and long-term mortality in male veterans following non-cardiac surgery. JAMA 1992, 268:228–232.

    Article  PubMed  CAS  Google Scholar 

  32. Mangano DT, Browner WS, Hollenberg M, et al.; Study of Perioperative Ischemia Research Group: Long-term cardiac prognosis following non-cardiac surgery. JAMA 1992, 268:233–239.

    Article  PubMed  CAS  Google Scholar 

  33. Howell SJ, Hemming AE, Allman KG, et al.: Predictors of postoperative myocardial ischaemia: the role of intercurrent arterial hypertension and other cardiovascular risk factors. Anaesthesia 1997, 52:107–111.

    Article  PubMed  CAS  Google Scholar 

  34. Stamler J, Stamler R, Neaton JD: Blood pressure, systolic and diastolic, and cardiovascular risks. US population data. Arch Intern Med 1993, 153:598–615.

    Article  PubMed  CAS  Google Scholar 

  35. Sear JW, Foex P, Howell SJ: Effect of chronic intercurrent medication with beta-adrenoceptor blockade or calcium channel entry blockade on postoperative silent myocardial ischaemia. Br J Anaesth 2000, 84:311–315.

    PubMed  CAS  Google Scholar 

  36. Pons-Llado G, Ballester M, Borras X, et al.: Myocardial cell damage in human hypertension. J Am Coll Cardiol 2000, 36:2198–2203.

    Article  PubMed  CAS  Google Scholar 

  37. Reddy GC, Kusumanjali G, Sharada AHR, Rao P: Cardiac troponin-T and CK-MB (mass) levels in cardiac and noncardiac disease. Indian J Clin Biochem 2004, 19:91–94.

    Article  CAS  Google Scholar 

  38. Howell SJ, Sear JW, Foex P: Hypertension, hypertensive heart disease and perioperative cardiac risk. Br J Anaesth 2004, 92:570–583.

    Article  PubMed  CAS  Google Scholar 

  39. Kheterpal K, Tremper KK, Englesbe MJ, et al.: Predictors of postoperative acute renal failure after noncardiac surgery in patients with previously normal renal function. Anesthesiology 2007, 107:892–902.

    Article  PubMed  Google Scholar 

  40. Howell SJ, Sear YM, Yeates D, et al.: Hypertension, admission blood pressure and perioperative cardiovascular risk. Anaesthesia 1996, 51:1000–1004.

    Article  PubMed  CAS  Google Scholar 

  41. Howell SJ, Sear YM, Yeates D, et al.: Risk factors for cardiovascular death following elective surgery under general anaesthesia. Br J Anaesth 1998, 80:14–19.

    PubMed  CAS  Google Scholar 

  42. Aronson S, Boisvert D, Lapp W: Isolated systolic hypertension is associated with adverse outcomes from coronary artery bypass grafting surgery. Anesth Analg 2002, 94:1079–1084.

    Article  PubMed  Google Scholar 

  43. Bond R, Narayan SK, Rothwell PL, Warlow CP: Clinical and radiologic risk factors for operative stroke and death in the European Carotid Surgery trial. Eur J Vasc Endovasc Surg 2002, 23:108–116.

    Article  PubMed  CAS  Google Scholar 

  44. Felmeden DC, Lip GY, Beevers M, Beevers DG: The placebo effect and white coat effect in isolated systolic hypertension and systo-diastolic hypertension. Blood Press 2000, 9:335–339.

    Article  PubMed  CAS  Google Scholar 

  45. Tamborini G, Maltagliata A, Trupiano L, et al.: Lowering of blood pressure and coronary blood flow in isolated systolic hypertension. Coron Artery Dis 2001, 12:259–265.

    Article  PubMed  CAS  Google Scholar 

  46. Aronson S, Fontes ML, Miao Y, Mangano DT; Investigators of the Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation: Risk index for perioperative renal dysfunction/failure. Critical dependence on pulse pressure hypertension. Circulation 2007, 115:733–742.

    Article  PubMed  Google Scholar 

  47. Benjo A, Thompson RE, Fine D, et al.: Pulse pressure is an age-independent predictor of stroke development after cardiac surgery. Hypertension 2007, 50, 630–635.

    Article  PubMed  CAS  Google Scholar 

  48. Muscholl MW, Hense H-W, Brockel U, et al.: Changes in left ventricular structure and function in patients with white coat hypertension: cross sectional survey. Br Med J 1998, 317:565–570.

    CAS  Google Scholar 

  49. Nalbantgil I, Onder R, Nalbantgil S, et al.: The prevalence of silent myocardial ischaemia in patients with white-coat hypertension. J Hum Hypertens 1998, 12:337–341.

    Article  PubMed  CAS  Google Scholar 

  50. Kroen C: Does elevated blood pressure at the time of surgery increase perioperative cardiac risk? IMPACT consults. Proceedings of the 2nd Annual Cleveland Clinic Perioperative Medicine Summit. Cleve Clin J Med 2006, 73:S5–S6.

    Article  PubMed  Google Scholar 

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Sear, J.W. Perioperative control of hypertension: When will it adversely affect perioperative outcome?. Current Science Inc 10, 480–487 (2008). https://doi.org/10.1007/s11906-008-0090-2

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