Skip to main content

Advertisement

SpringerLink
Log in

Aldosterone and CKD in metabolic syndrome

  • Invited Commentary
  • Published:
Current Hypertension Reports Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References and Recommended Reading

  1. Chen J, Muntner P, Hamm LL, et al.: The metabolic syndrome and chronic kidney disease in US adults. Ann Intern Med 2004, 140:167–174.

    PubMed  Google Scholar 

  2. Nagase M, Yoshida S, Shibata S, et al.: Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors. J Am Soc Nephrol 2006, 17:3438–3446.

    Article  PubMed  CAS  Google Scholar 

  3. Nagase M, Matsui H, Shibata S, et al.: Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor. Hypertension 2007, 50:877–883.

    Article  PubMed  CAS  Google Scholar 

  4. Ehrhart-Bornstein M, Lamounier-Zepter V, Schraven A, et al.: Human adipocytes secrete mineralocorticoid-releasing factors. Proc Natl Acad Sci U S A 2003, 100:14211–14216.

    Article  PubMed  CAS  Google Scholar 

  5. Matsui H, Ando K, Kawarazaki H, et al.: Salt excess causes left ventricular diastolic dysfunction in rats with metabolic disorder. Hypertension 2008, 52:287–294.

    Article  PubMed  CAS  Google Scholar 

  6. Verhave JC, Hillege HL, Burgerhof JG, et al.; PREVEND Study Group: Sodium intake affects urinary albumin excretion especially in overweight subjects. J Intern Med 2004, 256:324–330.

    Article  PubMed  CAS  Google Scholar 

  7. Nagase M, Shibata S, Yoshida S, et al.: Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker. Hypertension 2006, 47:1084–1093.

    Article  PubMed  CAS  Google Scholar 

  8. Funder JW: Is aldosterone bad for the heart? Trends Endocrinol Metab 2004, 15:139–142.

    Article  PubMed  CAS  Google Scholar 

  9. Bossis G, Melchio F: Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes. Mol Cell 2006, 21:349–357.

    Article  PubMed  CAS  Google Scholar 

  10. Pitt B: Effect of aldosterone blockade in patients with systolic left ventricular dysfunction: implications of the RALES and EPHESUS studies. Mol Cell Endocrinol 2004, 217:53–58.

    Article  PubMed  CAS  Google Scholar 

  11. Bochud M, Nussberger J, Bovet P, et al.: Plasma aldosterone is independently associated with the metabolic syndrome. Hypertension 2006, 48:239–245.

    Article  PubMed  CAS  Google Scholar 

  12. Onozato ML, Tojo A, Kobayashi N, et al.: Dual blockade of aldosterone and angiotensin II additively suppresses TGFβ and NADPH oxidase in the hypertensive kidney. Nephrol Dial Transplant 2007, 22:1314–1322.

    Article  PubMed  CAS  Google Scholar 

  13. Epstein M, Buckalew V, Martinez F, et al.: Antiproteinuric efficacy of eplerenone, enalapril, and eplerenone/enalapril combination in diabetic hypertensives with microalbuminuria [abstract]. Am J Hypertens 2002, 15:24A.

    Article  Google Scholar 

  14. Hinokio Y, Suzuki S, Hirai M, et al.: Urinary excretion of 8-oxo-7,8-dihydro-2′-deoxyguanosine as a predictor of the development of diabetic nephropathy. Diabetologia 2002, 45:877–882.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nephrology and Endocrinology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Toshiro Fujita

Authors
  1. Toshiro Fujita
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Toshiro Fujita.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fujita, T. Aldosterone and CKD in metabolic syndrome. Current Science Inc 10, 421–423 (2008). https://doi.org/10.1007/s11906-008-0078-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11906-008-0078-y

Keywords

Search

Navigation