Skip to main content
SpringerLink
Log in

Direct renin inhibitors: Where will they fit in for antihypertensive treatment?

  • Clinical Trials Report
  • Published:
Current Hypertension Reports Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Weir MR, Bush C, Anderson DR, et al.: Antihypertensive efficacy, safety, and tolerability of the oral direct renin inhibitor aliskiren in patients with hypertension: a pooled analysis. J Am Soc Hypertens 2007, 1:264–277.

    Article  Google Scholar 

  2. Sealey JE, Laragh JH: Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its effectiveness. Am J Hypertens 2007, 20:587–597.

    Article  PubMed  CAS  Google Scholar 

  3. Weir MR: Providing end-organ protection with renin-angiotensin system inhibition: the evidence so far. J Clin Hypertens (Greenwich) 2006, 8:99–105.

    Article  CAS  Google Scholar 

  4. Pool JL, Guthrie RM, Littlejohn TW III, et al.: Dose-related antihypertensive effects of irbesartan in patients with mild-to-moderate hypertension. Am J Hypertens 1998, 11:462–470.

    Article  PubMed  CAS  Google Scholar 

  5. Oparil S, Yarows SA, Patel S, et al.: Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial. Lancet 2007, 370:221–229.

    Article  PubMed  CAS  Google Scholar 

  6. Azizi M: Renin inhibition: the next step in suppression of the renin-angiotensin system? Curr Hypertens Rep 2007, 9:81–83.

    Article  PubMed  Google Scholar 

  7. O’Brien E, Barton J, Nussberger J, et al.: Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker. Hypertension 2007, 49:276–284.

    Article  PubMed  CAS  Google Scholar 

  8. Azizi M, Menard J, Bissery A, et al.: Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol 2004, 15:3126–3133.

    Article  PubMed  Google Scholar 

Download references

Authors
  1. Matthew R. Weir
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weir, M.R. Direct renin inhibitors: Where will they fit in for antihypertensive treatment?. Current Science Inc 9, 389–391 (2007). https://doi.org/10.1007/s11906-007-0071-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11906-007-0071-x

Keywords

Search

Navigation