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Vascular angiotensin II actions mediated by angiotensin II type 2 receptors

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Abstract

Angiotensin II (Ang II) is the major effector peptide of the renin-angiotensin system and acts at two major receptors known as Ang II type 1 receptor (AT1R) and Ang II type 2 receptor (AT2R). Increasingly, there is evidence suggesting that the AT2R counter-regulates the excitatory effects of AT1R stimulation. In this review, we have focused on pharmacodynamic and trophic components of AT2R with respect to vascular function, and put the current status of vascular AT2R research in the context of a potential role for this ATR subtype in the therapeutic effects of AT1R antagonists.

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  1. Department of Pharmacology, Monash University-Clayton, Wellington Road, 3800, Melbourne, Victoria, Australia

    Ruth E. Hannan PhD & Robert E. Widdop PhD

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  1. Ruth E. Hannan PhD
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Hannan, R.E., Widdop, R.E. Vascular angiotensin II actions mediated by angiotensin II type 2 receptors. Current Science Inc 6, 117–123 (2004). https://doi.org/10.1007/s11906-004-0086-5

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