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Angiotensin II and abdominal aortic aneurysms

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Abstract

Abdominal aortic aneurysms (AAAs) have devastating effects on the morbidity and mortality of a large portion of the elderly population. Current therapeutic options for AAAs are limited to surgical approaches, because there are no proven pharmacologic treatments. Recently, there is evolving evidence that angiotensin II (Ang II) participates in the initiation and propagation of AAAs. Animal studies have consistently demonstrated the ability of Ang II to promote the formation of AAAs, although the mechanisms of this effect have not been defined. Further definition of the role of the renin-angiotensin system in AAA formation and progression will identify potential therapeutic strategies for treatment of this disease.

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, 2 Graduate Center for Nutritional Sciences, Gill Heart Institute, University of Kentucky, Wethington Building, Room 521, 40536-0200, Lexington, KY, USA

    Alan Daugherty PhD, DSc & Lisa Cassis PhD

Authors
  1. Alan Daugherty PhD, DSc
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  2. Lisa Cassis PhD
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Daugherty, A., Cassis, L. Angiotensin II and abdominal aortic aneurysms. Current Science Inc 6, 442–446 (2004). https://doi.org/10.1007/s11906-004-0038-0

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  • DOI: https://doi.org/10.1007/s11906-004-0038-0

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