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Current Hypertension Reports

, Volume 6, Issue 1, pp 27–30 | Cite as

Antioxidant vitamins and blood pressure

  • Sébastien Czernichow
  • Jacques Blacher
  • Serge Hercberg
Article

Abstract

Synthesis of free radicals might play a role in the cellular process of atherosclerosis. This process can be stopped by antioxidants such as betacarotene, vitamin C, or vitamin E, which will inactivate the effects of free radicals. Although antioxidant vitamins have not been proven to prevent cardiovascular diseases through the modulation of lipid peroxidation, it has been suggested that peroxidation might be a pathway to such prevention, mediated through the effects of antioxidants on blood pressure (BP) and arterial stiffness. Several observational epidemiologic studies and some clinical trials have suggested an inverse association between dietary intake of fruits and vegetables, and BP. An inverse link between serum levels of vitamin C and BP has also been determined in observational epidemiologic settings. Some relations between other antioxidant vitamins (retinol and betacarotene) and BP are reported; they confer the same inverse association. However, results from clinical trials testing the effect of a single, or a combination of antioxidants at high pharmacologic doses have revealed inconsistent BP findings. So far, no evidence confirms that oral antioxidant supplementation is effective in preventing or treating high BP. Additional large studies should be conducted to determine the effect on BP of antioxidant supplementation at nutritional doses.

Keywords

Arterial Stiffness Betacarotene Vegetable Intake Antioxidant Vitamin Plasma Ascorbic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Current Science Inc 2004

Authors and Affiliations

  • Sébastien Czernichow
    • 1
  • Jacques Blacher
    • 1
  • Serge Hercberg
    • 1
  1. 1.French Institute of Health and Medical Research (INSERM, Unit 557), UMR (INSERM/INRA/CNAM)ParisFrance

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