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The role of the sympathetic nervous system in linking obesity with hypertension in white versus black Americans

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Abstract

Several previous studies confirmed that obesity is a major risk factor for the development of cardiovascular diseases, including hypertension. A large number of clinical studies considered the role of the sympathetic nervous system in linking obesity with hypertension, and there is substantial evidence that human obesity is characterized by defects in sympathetic cardiovascular control. The association of obesity with hypertension has been well documented in most racial, ethnic, and socioeconomic groups. Ethnicity may be an important factor to consider since sympathetic nervous system activity, and the propensity for obesity and hypertension, all differ substantially among different populations. Obesity is actually accompanied by increased sympathetic nerve discharge to skeletal muscles, a main site for energy expenditure. Adiposity-related sympathetic overactivity is a compensatory mechanism to burn fat and decrease weight gain, but at the cost of increased sympathetic discharge to the peripheral vasculature, which could predispose to hypertension. Thus, sympathetic nervous system activity is important in the development and maintenance of obesity-related hypertension in different racial and ethnic populations, including white and black Americans.

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References and Recommended Reading

  1. Dustan HP: Obesity and hypertension in blacks. Cardiovasc Drugs Ther 1990, 4(Suppl 2):395–402.

    Article  PubMed  Google Scholar 

  2. Fray JCS, Douglas JG: Pathophysiology of Hypertension in Blacks. New York, NY: Oxford University Press; 1993.

    Google Scholar 

  3. Cooper R, Rotimi C: Hypertension in blacks. Am J Hypertens 1997, 7:804–812.

    Article  Google Scholar 

  4. Calhoun DA: Hypertension in blacks: socioeconomic stress and sympathetic nervous system activity. Am J Med Sci 1992, 5:304–306.

    Google Scholar 

  5. Calhoun DA, Oparil S: Racial differences in the pathogenesis of hypertension. Am J Med Sci 1995, 310:S86-S90.

    Article  PubMed  Google Scholar 

  6. Liu K, Ruth KJ, Flack JM, et al.: Blood pressure in young blacks and whites: relevance of obesity and lifestyle factors in determining differences: (The Cardia Study). Circulation 1993, 1:60.

    Google Scholar 

  7. Neser WB, Thomas J, Semenya K, et al.: Obesity and hypertension in a longitudinal study of black physicians: (The Meharry Cohort Study). J Chron Dis 1986, 39:105–113.

    Article  PubMed  CAS  Google Scholar 

  8. Tuck ML, Sowers JR, Dornfeld L, et al.: Reductions in plasma catecholamines and blood pressure during weight loss in obese subjects. Acta Endocrinol (Copenh) 1983, 102:252–257.

    CAS  Google Scholar 

  9. Young JB, Macdonald IA: Sympathoadrenal activity in human obesity: heterogeneity of findings since 1980. Int J Obes Relat Metab Disord 1992, 16:959–967.

    PubMed  CAS  Google Scholar 

  10. Gonzalez-Trapaga JL, Nelesen RA, Dimsdale JE, et al.: Plasma Epinephrine levels in hypertension and across gender and ethnicity. Life Sci 2000, 66:2383–2392.

    Article  PubMed  CAS  Google Scholar 

  11. Mikhail N, Golub MS, Tuck ML: Obesity and hypertension. Prog Cardio Dis 1999, 42:39–58. CMA recent and complete review of obesity and hypertension.

    Article  CAS  Google Scholar 

  12. Grossman E, Chang PC, Hoffman A, et al.: Tracer norepinephrine kinetics: dependence on regional blood flow and the site of infusion. Am J Physiol 1991, 260:R946-R952.

    PubMed  CAS  Google Scholar 

  13. Eisenhofer G, Esler MD, Goldstein DS, et al.: Neuronal uptake, metabolism, and release of tritium-labeled norepinephrine during assessment of its plasma kinetics. Am J Physiol 1991, 261:E505-E515.

    PubMed  CAS  Google Scholar 

  14. Esler MD, Lambert G, Jennings GL: Increased regional sympathetic nerve activity in human hypertension: causes and consequences. J Hypertens 1990, 8(Suppl 7):S53-S57.

    CAS  Google Scholar 

  15. Vaz M, Jennings GL, Turner A, et al.: Regional sympathetic nervous activity and oxygen consumption in obese normotensive human subjects. Circulation 1997, 6:3423–3429.

    Google Scholar 

  16. Esler M, Lambert G, Vaz M, et al.: Central nervous system monoamine neurotransmitter turnover in primary and obesity-related human hypertension. Clin Exp Hypertens 1997, 19:577–590.

    Article  PubMed  CAS  Google Scholar 

  17. Masuo K: Obesity-related hypertension: role of sympathetic nervous system, insulin, and leptin. Curr Hypertens Rep 2002, 2:112–118.

    Google Scholar 

  18. Anderson EA, Sinkey CA, Lawton WJ, Mark AL: Elevated sympathetic nerve activity in borderline hypertensive man: Evidence from direct intraneuronal recordings. Hypertension 1989, 14:177–183.

    PubMed  CAS  Google Scholar 

  19. Jones PP, Snitker S, Skinner JS, Ravussin E: Gender differences in muscle sympathetic nerve activity: effect of body fat distribution. Am J Physiol 1996, 270:363–366.

    Google Scholar 

  20. Gudbjornsdottir S, Lonnroth P, Sverrisdottir YB, et al.: Sympathetic nerve activity and insulin in obese normotensive and hypertensive men. Hypertension 1996, 27:276–280.

    PubMed  CAS  Google Scholar 

  21. Weyer C, Pratley RE, Snitker S, et al.: Ethnic differences in insulinemia and sympathetic tone as links between obesity and blood pressure. Hypertension 2000, 36:531–537.

    PubMed  CAS  Google Scholar 

  22. Spraul M, Ravussin E, Fontvieille AM, et al.: Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain. J Clin Invest 1993, 92:1730–1735.

    PubMed  CAS  Google Scholar 

  23. Calhoun DA, Mutinga ML, Wyss JM, Oparil S: Muscle sympathetic nervous system activity in black and Caucasian hypertensive subjects. J Hypertens 1994, 12:1291–1296.

    Article  PubMed  CAS  Google Scholar 

  24. Abate NI, Mansour YH, Tuncel M, et al.: Overweight and sympathetic overactivity in black Americans. Hypertension 2001, 38:379–383. Most complete study comparing SNS in black and white obese subjects.

    PubMed  CAS  Google Scholar 

  25. Narkiewicz K, Van de Borne PJ, Cooley RL, et al.: Sympathetic activity in obese subjects with and without obstructive sleep apnea. Circulation 1998, 98:772–776. A landmark study showing that obstructive sleep apnea raises SNS activity in obese subjects; those without sleep apnea had normal SNS activity.

    PubMed  CAS  Google Scholar 

  26. Grassi G, Colombo M, Seravalle G, et al.: Dissociation between muscle and skin sympathetic nerve activity in essential hypertension, obesity, and congestive heart failure. Hypertension 1998, 31:64–67.

    PubMed  CAS  Google Scholar 

  27. Hall JE, Hildebrandt DA, Kuo J: Obesity hypertension: role of leptin and sympathetic nervous system. Am J Hypertens 2001, 14:S103-S115.

    Article  Google Scholar 

  28. Haynes WG, Morgan DA, Sivitz WI, et al.: Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 1997, 100:270–278.

    PubMed  CAS  Google Scholar 

  29. O’Hare JA, Minaker KL, Meneilly CS, et al.: Effect of insulin on plasma norepinephrine and 3, 4 dihydroxyphenylalanine in obese men. Metabolism 1989, 38:322–329.

    Article  PubMed  CAS  Google Scholar 

  30. Anderson EA, Mark AL: The vasodilatory action of insulin. Implications for the insulin hypothesis in hypertension. Hypertension 1993, 21:136–141.

    PubMed  CAS  Google Scholar 

  31. Corry DB, Tuck ML: Insulin and glucoregulatory hormones: Implications for antihypertensive therapy. In Calcium Antagonists in Clinical Medicine. Edited by Epstein M. Philadelphia: Hanley and Belfus; 1998:217–241.

    Google Scholar 

  32. Barron AD: Insulin and the vasculature—old actors, new roles. J Invest Med 1996, 8:406–412.

    Google Scholar 

  33. Scherrer U, Randin D, Vollenweinder P, Nicod P: Nitric oxide release accounts for insulin’s vascular effects in humans. J Clin Invest 1994, 94:2511–2515.

    Article  PubMed  CAS  Google Scholar 

  34. Masuo K, Mikami H, Ogihara T, Tuck ML: Weight reduction and pharmacologic treatment in obese hypertensives. Am J Hypertens 2001, 14:530–538.

    Article  PubMed  CAS  Google Scholar 

  35. Reisen E, Weir MR, Falkner B, et al.: Lisinopril versus hydrochlorothiazide in obese hypertensive patients. A Multicenter placebo-controlled trial. Hypertension 1997; 30(Pt1):145–155.

    Google Scholar 

  36. Corry DB, Tuck ML: Implications of glucoregulatory hormones in antihypertensive therapy. In Calcium Antagonists in Clinical Medicine, edn 3. Philadelphia: Hanley & Belfus; 2002:161–180.

    Google Scholar 

  37. Tuck ML: Obesity, the sympathetic nervous system and essential hypertension. Hypertension 1992, 19(Suppl 1):167–177.

    Google Scholar 

  38. Grassi G, Seravelle G, Cattaneo BM, et al.: Sympathetic activation in obese normotensive subjects. Hypertension 1995, 25:560–563.

    PubMed  CAS  Google Scholar 

  39. Landsberg L: Insulin and the sympathetic nervous system in the pathophysiology of hypertension. Blood Press Suppl 1996, 1:25–29.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Veterans Affairs Medical Center, 16111 Plummer Street, 91343, Sepulveda, CA, USA

    Pirooz Eslami MD & Michael Tuck MD

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  1. Pirooz Eslami MD
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  2. Michael Tuck MD
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Eslami, P., Tuck, M. The role of the sympathetic nervous system in linking obesity with hypertension in white versus black Americans. Current Science Inc 5, 269–272 (2003). https://doi.org/10.1007/s11906-003-0031-z

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  • DOI: https://doi.org/10.1007/s11906-003-0031-z

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