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Knockout of renin-angiotensin system genes: Effects on vascular development

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Abstract

Pharmacologic inhibition of the renin-angiotensin system (RAS) is a widely accepted and effective treatment for hypertension. However, in the past several years, much attention has been focused on additional roles of the RAS including the possibility that its end-product, angiotensin II, could elicit end-organ pathologies independent of its effect on blood pressure. The ability to selectively delete genes in mice (by homologous recombination or gene knockouts) has led to new — and sometimes surprising — insights into the roles of the RAS in the developmental modeling and pathologic remodeling of the heart and blood vessels.

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Authors and Affiliations

  1. Department of Pathology, University of Washington, Vascular Biology, 98195-7335, Seattle, WA, USA

    Danielle Methot PhD

  2. Laboratory of Molecular Biochemistry of Hypertension and MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, 110 Pine Avenue West, H2W 1R7, Montreal, Quebec, Canada

    Timothy L. Reudelhuber PhD

Authors
  1. Danielle Methot PhD
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  2. Timothy L. Reudelhuber PhD
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Methot, D., Reudelhuber, T.L. Knockout of renin-angiotensin system genes: Effects on vascular development. Current Science Inc 3, 68–73 (2001). https://doi.org/10.1007/s11906-001-0083-x

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  • DOI: https://doi.org/10.1007/s11906-001-0083-x

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