Management of Autoimmune Hepatitis Patients Refractory to or Intolerant of Standard Therapies

Autoimmune, Cholestatic, and Biliary Diseases (S Gordon and C Bowlus, Section Editors)
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  1. Topical Collection on Autoimmune, Cholestatic, and Biliary Diseases

Abstract

Purpose of Review

Autoimmune hepatitis is a progressive T cell-dependent inflammatory process characterized by elevated autoantibodies, serum globulins, and interface hepatitis. Pharmacologic treatment focuses on achievement of complete biochemical remission. The goal of this paper is to describe the unique features that guide treatment in difficult-to-control cases of autoimmune hepatitis.

Recent Findings

Recently published retrospective reviews have noted the efficacy of multiple second- and third-line agents in the treatment of autoimmune hepatitis. There has been no widely accepted approach regarding which agents to use in specific patient populations.

Summary

This paper attempts to summarize recent evidence regarding treatment efficacy of second- and third-line therapies and addresses patient-specific considerations when deciding which therapies to choose.

Keywords

Autoimmune hepatitis Second-line Mycophenolate Calcineurin inhibitor mTOR Rituximab Skin cancer 

Notes

Compliance with Ethical Standards

Conflict of Interest

Keaton R Jones and Craig S Lammert declare no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. 1.Department of MedicineIndiana University School of MedicineIndianapolisUSA

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