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Current Hepatology Reports

, Volume 16, Issue 1, pp 12–17 | Cite as

Use of Hepatitis C-Positive Donor Livers in Liver Transplantation

  • Daniel Bushyhead
  • David GoldbergEmail author
Hepatitis C (J Ahn and A Aronsohn, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Hepatitis C

Abstract

Purpose of Review

The purpose of this article is to review recent literature regarding the use of hepatitis C virus (HCV)-positive donor livers in liver transplantation. Given the prevalence of HCV-positive patients on the waitlist coupled with high waitlist mortality, use of HCV-positive livers may be a means to meet patient needs. This review seeks to primarily answer the following questions: can HCV-positive livers be used safely and effectively? Are new direct-acting antiviral medications safe and effective in HCV-positive liver recipients?

Recent Findings

Use of HCV-positive donor livers for liver transplantation in HCV-positive recipients is increasing. These donor livers have equivalent patient and graft survival when compared to HCV-negative donor livers in HCV-positive liver transplant recipients. Recent studies suggest that use of direct-acting antiviral medications in HCV-positive liver transplant recipients can be successful, although there is insufficient data for their use in recipients of HCV-positive donor livers.

Summary

HCV-positive donor livers may be safely and effectively used in HCV-positive liver transplant recipients. Direct-acting antiviral medications appear safe and effective in HCV-positive liver transplant recipients, but data on their efficacy in HCV-positive donor liver transplant recipients are limited. Future research should focus on the use of HCV-positive donor livers in HCV-negative liver transplant recipients.

Keywords

Hepatitis C virus Liver transplantation Direct-acting antivirals HCV-positive organs HCV-positive livers HCV-positive liver transplantation 

Notes

Compliance with Ethical Standards

Conflict of Interest

Daniel Bushyhead and David Goldberg each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

References

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of Medicine, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Division of Gastroenterology, Department of Medicine, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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