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Invasive and Non-invasive Diagnosis of Portal Hypertension in Cirrhosis

  • Portal Hypertension (JC Garica-Pagán, Section Editor)
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Abstract

In the natural history of any chronic liver disease the occurrence of liver related complications is related to the portal hypertension development. Therefore, in the diagnosis work up of any liver disease the portal hypertension assessment is an indispensable step. The most accurate method for portal hypertension diagnosis is hepatic venous pressure gradient (HVPG), which implies central venous access and the catheterization of the hepatic vein. HVPG is the strongest prognostic marker in chronic liver diseases. It accurately predicts the risk of esophageal varices development and hemorrhage, the risk of decompensation as well as the mortality. Also HVPG represents a method to tailor portal hypertension treatment. However, due to the invasiveness of the procedure, there is an extensive effort to find non-invasive methods that could replace HVPG measurement. By now, only liver stiffness measuring proves to have good performances even there are issues about cut-offs and feasibility in overweight patients.

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Dr. Christophe Bureau and Dr. Bogdan Procopet have nothing to disclose.

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Authors and Affiliations

  1. Gastroenterology Departement, 3rd Medical Clinic, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania

    Bogdan Procopet

  2. Gastroenterology Department, Regional Institute of Gastroenterology and Hepatology “O Fodor”, Cluj-Napoca, Romania

    Bogdan Procopet

  3. Hepatic Hemodynamic Laboratory, Liver Unit and IDIBAPS, Hospital Clinic, Barcelona, Spain

    Bogdan Procopet

  4. Department of Hepato-Gastroenterology, Purpan Hospital, CHU, Toulouse, France

    Christophe Bureau

  5. INSERM U858 and University of Toulouse, Toulouse, France

    Christophe Bureau

  6. Service d’Hépato-gastro-Enterologie. Fédération Digestive CHU Toulouse Purpan, 31059, Toulouse cedex, France

    Christophe Bureau

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Procopet, B., Bureau, C. Invasive and Non-invasive Diagnosis of Portal Hypertension in Cirrhosis. Curr Hepatology Rep 13, 180–188 (2014). https://doi.org/10.1007/s11901-014-0237-3

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