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TIPS in Variceal Bleeding: New and Old Indications

  • Portal Hypertension (JC Garcia-Pagán, Section editor)
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Abstract

Variceal bleeding is one of the most dreaded complications of cirrhosis and its occurrence is associated with significant morbidity and mortality. During the past 30 years preventative therapies have reduced the risk of the first variceal bleed. Once variceal bleeding occurs use of pharmacologic and endoscopic therapies prevent rebleeding in most patients. The existing recommendations are that TIPS only be used in those patients who fail medical therapy. We reviewed recent literature focusing on the role of early TIPS in management of acute variceal hemorrhage and prevention of re-bleeding.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Rösch J, Hanafee W, Snow H. Transjugular portal venography and radiologic portacaval shunt: an experimental study. Radiology. 1969;92:1112–4.

    Article  PubMed  Google Scholar 

  2. Eesa M, Clark T. Transjugular intrahepatic porto-systemic shunt: state of the art. Semin Roentgenol. 2011;46:125–32.

    Article  PubMed  Google Scholar 

  3. La Mura V, Abraldes JG, Berzigotti A, Erice E, Flores-Arroyo A, García-Pagán JC, et al. Right atrial pressure is not adequate to calculate portal pressure gradient in cirrhosis: a clinical-hemodynamic correlation study. Hepatology. 2010;51(6):2108–16. doi:10.1002/hep.23612.

    Article  PubMed  Google Scholar 

  4. Boyer TD, Haskal Z. AASLD Practice Guidelines: The role of transjugular intrahepatic portosystemic shunt in the management of portal hypertension. Hepatology. 2005;41:386–400.

    Article  PubMed  Google Scholar 

  5. Bureau C, Garcia-Pagan JC, Otal P, Pomier-Layrargues G, Chabbert V, et al. Improved clinical outcome using polytetrafluoroethylene-coated stents for TIPS: Results of a randomized study. Gastroenterology. 2004;126:469–75.

    Article  PubMed  Google Scholar 

  6. Boyer TD. Risk stratification and candidates for transjugular intrahepatic portosystemic shunts. In: Arroyo V, Abraldes JG, Gines P, Sanchez-Tapias JM, Forns X, Bataller R, Rodes J, editors. Treatment of Liver Diseases. Barcelona: Ars Medica; 2009. p. 199–204.

    Google Scholar 

  7. Lodato F, Berzigotti A, Lisotti A, Azzaroli F, Mosconi C, Giampalma E, et al. Transjugular intrahepatic portosystemic shunt placement for refractory ascites: a single-centre experience. Scand J Gastroenterol. 2012;47(12):1494–500.

    Article  PubMed  Google Scholar 

  8. Raszeja-Wyszomirska J, Mieżyńska-Kurtycz J, Marlicz W, Lawniczak M, Wójcicki M. Primary Budd-Chiari syndrome - a single center experience. Hepatogastroenterology. 2012;59(118):1879–82.

    PubMed  Google Scholar 

  9. Harnik I, Golowa Y, Massoumi H. Portal hypertensive vaginal bleeding. Hepatology. 2013;57(5):2085–6.

    Article  PubMed  Google Scholar 

  10. D’Avola D, Bilbao JI, Zozaya G, Pardo F, Rotellar F, Iñarrairaegui M, et al. Efficacy of transjugular intrahepatic portosystemic shunt to prevent total portal vein thrombosis in cirrhotic patients awaiting for liver transplantation. Transplant Proc. 2012;44(9):2603–5.

    Article  PubMed  Google Scholar 

  11. Qi X, Han G, He C, Yin Z, Zhang H, Wang J, et al. Transjugular intrahepatic portosystemic shunt may be superior to conservative therapy for variceal rebleeding in cirrhotic patients with non-tumoral portal vein thrombosis: a hypothesis. Med Sci Monit. 2012;18(8):HY37–41.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Kim MJ, Jang BK, Chung WJ, Hwang JS, Kim YH. Duodenal variceal bleeding after balloon-occluded retrograde transverse obliteration: treatment with transjugular intrahepatic portosystemic shunt. World J Gastroenterol. 2012;18(22):2877–80.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Villanueva C, Colomo A, Bosch A, Conceptcion M, Hernandez Gea V, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Eng J Med. 2013;368:11–21.

    Article  CAS  Google Scholar 

  14. Boyer TD, Haskal ZJ. American Association for the Study of Liver Diseases. The Role of Transjugular Intrahepatic Portosystemic Shunt (TIPS) in the Management of Portal Hypertension: update 2009. Hepatology. 2010;51(1):306.

    Article  PubMed  Google Scholar 

  15. de Franchis R, Baveno V. Faculty. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2010;53(4):762–8.

    Article  PubMed  Google Scholar 

  16. Salerno F, Camma C, Enea M, Rossle M, Wong F. Transjugular intrahepatic portosystemic shunt for refractory ascites: A meta-analysis of individual patient data. Gastroenterology. 2007;133:825–34.

    Article  CAS  PubMed  Google Scholar 

  17. García-Pagán JC, Caca K, Bureau C, Laleman W, Appenrodt B, Luca A, et al. Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med. 2010;362(25):2370–9.

    Article  PubMed  Google Scholar 

  18. Monescillo A, Martínez-Lagares F, Ruiz-del-Arbol L, Sierra A, Guevara C, Jiménez E, et al. Influence of portal hypertension and its early decompression by TIPS placement on the outcome of variceal bleeding. Hepatology. 2004;40(4):793–801.

    Article  PubMed  Google Scholar 

  19. Garcia-Pagán JC, Di Pascoli M, Caca K, Laleman W, Bureau C, Appenrodt B, et al. Use of early-TIPS for high-risk variceal bleeding: results of a post-RCT surveillance study. J Hepatol. 2013;58(1):45–50.

    Article  PubMed  Google Scholar 

  20. Rudler M, Cluze P, Hammoudi N, Benosman H, Poynard T, Thal D, et al. Early TIPS in patients with acute variceal bleeding: an external validation. Hepatology. 2013;58:290A.

    Google Scholar 

  21. Harman DJ, McCorry RB, Jacob RP, Lim TR, O'Neill R, Ryder SD, et al. Economic modeling early transjugular intrahepatic portosystemic shunt insertion for acute variceal haemorrhage. Eur J Gastroenterol Hepatol. 2013;25(2):201–7.

    Article  PubMed  Google Scholar 

  22. Garcia-Pagán JC, Barrufet M, Cardenas A, Escorsell A. Management of Gastric Varices. Clin Gastroenterol Hepatol. 2013;S1542-3565(13):01059-8. doi:10.1016/j.cgh.2013.07.015.

    Google Scholar 

  23. Park EJ, Jang JY, Lee JE, Jeong SW, Lee SH, Kim SG, et al. The risk factors for bleeding of fundal varices in patients with liver cirrhosis. Gut Liver. 2013;7(6):704–11.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Lo GH, Liang HL, Chen WC, Chen MH, Lai KH, Hsu PI, et al. A prospective, randomized controlled trial of transjugular intrahepatic portosystemic shunt versus cyanoacrylate injection in the prevention of gastric variceal rebleeding. Endoscopy. 2007;39(8):679–85.

    Article  PubMed  Google Scholar 

  25. Procaccini NJ, Al-Osaimi AM, Northup P, Argo C, Caldwell SH. Endoscopic cyanoacrylate versus transjugular intrahepatic portosystemic shunt for gastric variceal bleeding: a single-center U.S. analysis. Gastrointest Endosc. 2009;70(5):881–7.

    Article  PubMed  Google Scholar 

  26. Saad WE, Darcy MD. Transjugular intrahepatic portosystemic shunt (TIPS) versus balloon-occluded retrograde transvenous obliteration (BRTO) for management of gastric varices. Semin Intervent Radiology. 2011;28:339–49.

    Article  Google Scholar 

  27. Biecker E. Portal hypertension and gastrointestinal bleeding: diagnosis, prevention and management. World J Gastroenterol. 2013;19(31):5035–50.

    Article  PubMed Central  PubMed  Google Scholar 

  28. Kamath PS, Shah VH. Portal hypertension and bleeding esophageal varices. In: Boyer TD, Manns MP, Sanyal AJ, editors. Zakim and Boyer’s Hepatology: A textbook of liver disease. 6th ed. New York: Elsevier; 2012. p. 296–326.

    Chapter  Google Scholar 

  29. • Shi KQ, Liu WY, Pan ZZ, Lin XF, Chen SL, Chen YP, et al. Secondary prophylaxis of variceal bleeding for cirrhotic patients: a multiple-treatments meta-analysis. Eur J Clin Invest. 2013. doi:10.1111/eci.12115. This is an important multi-analysis evaluating the 12 choices including TIPS for secondary prophylaxis based on randomized controlled trials.

    PubMed  Google Scholar 

  30. Bosch J, Garcia-Pagan JC. Prevention of variceal rebleeding. Lancet. 2003;361:952–4.

    Article  PubMed  Google Scholar 

  31. Henderson JM, Boyer TD, Kutner M, Galloway JR, Rikkers LF, Jeffers LJ, et al. Distal splenorenal shunt versus transjugular intrahepatic portal systemic shunt for variceal bleeding: A randomized trial. Gastroenterology. 2006;130:1643–51.

    Article  PubMed  Google Scholar 

  32. Boyer TD, Henderson JM, Heerey AM, Arrigain S, Konig V, Connor J, et al. Cost of preventing variceal rebleeding with transjugular intrahepatic portal systemic shunt and distal splenorenal shunt. J Hepatology. 2008;48:407–14.

    Article  Google Scholar 

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Shahid Habib reports no conflict of interest.

Thomas D. Boyer is a paid consultant for Gore Medical.

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This article does not contain any studies with human or animal subjects performed by the authors.

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Correspondence to Thomas D. Boyer.

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Habib, S., Boyer, T.D. TIPS in Variceal Bleeding: New and Old Indications. Curr Hepatology Rep 13, 218–223 (2014). https://doi.org/10.1007/s11901-014-0223-9

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