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New and Improved Imaging Modalities for NAFLD

  • Fatty Liver Disease (SA Harrison and J George, Section editors)
  • Published:
Current Hepatology Reports Aims and scope Submit manuscript

Abstract

Non-invasive detection and quantitative assessment of NAFLD is important as it is associated with obesity, metabolic syndrome and insulin resistance. Differentiation of isolated steatosis (IS) from steatohepatitis (NASH) is critical as a NASH can progress to cirrhosis and develop associated complications such as portal hypertension and hepatocellular carcinoma. Current imaging techniques such as ultrasound and CT are useful for detection and can perform limited quantification of hepatic steatosis. Magnetic resonance imaging (MRI) techniques and MR spectroscopy (MRS) are accurate for fat quantification. Newer imaging techniques are emerging, which can provide more accurate fat quantification and differentiation of subtypes of NAFLD. Proton density fat fraction (PDFF) is an emerging MR based biomarker demonstrating promise for accurate fat quantification. Elastography techniques and in particular, magnetic resonance elastography (MRE) may be able to differentiate IS from NASH, although further studies are needed to confirm. MRI with MRE can provide a one-stop comprehensive evaluation of NAFLD including fat quantification and differentiation of NASH from IS.

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Acknowledgements

Scott B. Reeder is funded by NIH Grant

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Sudhakar Kundapur Venkatesh and Scott B. Reeder declare no conflicts of interest.

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  1. Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA

    Sudhakar Kundapur Venkatesh

  2. Departments of Radiology, Medical Physics, Biomedical Engineering, and Medicine, University of Wisconsin, Madison, WI, 53792, USA

    Scott B. Reeder

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Venkatesh, S.K., Reeder, S.B. New and Improved Imaging Modalities for NAFLD. Curr Hepatology Rep 13, 88–96 (2014). https://doi.org/10.1007/s11901-014-0212-z

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